(Q58376144)

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Aberrant nucleocytoplasmic localization of the retinoblastoma tumor suppressor protein in human cancer correlates with moderate/poor tumor differentiation

scientific article published on 10 December 2007

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29 December 2019

Aberrant nucleocytoplasmic localization of the retinoblastoma tumor suppressor protein in human cancer correlates with moderate/poor tumor differentiation (English)

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Europe PubMed Central

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29 December 2019

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Jashodeep Datta

3

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29 December 2019

Till Braunschweig

4

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29 December 2019

Joon-Yong Chung

5

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29 December 2019

Stephen M. Hewitt

6

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29 December 2019

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W Jiao

1

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29 December 2019

H-M Lin

2

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29 December 2019

S G Rane

7

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29 December 2019

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10 December 2007

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29 December 2019

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29 December 2019

27

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29 December 2019

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29 December 2019

3156-3164

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Nucleocytoplasmic shuttling of the retinoblastoma tumor suppressor protein via Cdk phosphorylation-dependent nuclear export

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Nuclear transport and cancer: from mechanism to intervention

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RB, the conductor that orchestrates life, death and differentiation

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Dual Mechanisms for the Inhibition of E2F Binding to RB by Cyclin-Dependent Kinase-Mediated RB Phosphorylation

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PKB/Akt phosphorylates p27, impairs nuclear import of p27 and opposes p27-mediated G1 arrest

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G1/S phosphorylation of the retinoblastoma protein is associated with an altered affinity for the nuclear compartment

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Germ line transmission of the Cdk4(R24C) mutation facilitates tumorigenesis and escape from cellular senescence

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Loss of Cdk4 expression causes insulin-deficient diabetes and Cdk4 activation results in beta-islet cell hyperplasia

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The APC tumour suppressor has a nuclear export function.

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PKB/Akt mediates cell-cycle progression by phosphorylation of p27(Kip1) at threonine 157 and modulation of its cellular localization

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Wide spectrum of tumors in knock-in mice carrying a Cdk4 protein insensitive to INK4 inhibitors.

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Invasive melanoma in Cdk4-targeted mice

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Exportin 1 (Crm1p) is an essential nuclear export factor

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E2F and cell cycle control: a double-edged sword

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The retinoblastoma gene product is bound in the nucleus in early G1 phase

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A DNA vector-based RNAi technology to suppress gene expression in mammalian cells

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Cytoplasmic relocalization and inhibition of the cyclin-dependent kinase inhibitor p27(Kip1) by PKB/Akt-mediated phosphorylation in breast cancer

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Neural computing in cancer drug development: predicting mechanism of action

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Regulating access to the genome: nucleocytoplasmic transport throughout the cell cycle

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A p16INK4a-insensitive CDK4 mutant targeted by cytolytic T lymphocytes in a human melanoma

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Germline mutations in the p16INK4a binding domain of CDK4 in familial melanoma

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Parc-ing p53 in the cytoplasm

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Identifiers

10.1038/SJ.ONC.1210970

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18071317%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

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29 December 2019

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