(Q57364039)

English

Combined analysis of 19 common validated type 2 diabetes susceptibility gene variants shows moderate discriminative value and no evidence of gene–gene interaction

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Combined analysis of 19 common validated type 2 diabetes susceptibility gene variants shows moderate discriminative value and no evidence of gene–gene interaction (English)

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type 2 diabetes

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Anders Albrechtsen

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A. Albrechtsen

4

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S. Madsbad

11

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N. Grarup

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Oluf Borbye Pedersen

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O. Pedersen

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Torben Jørgensen

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T. Jørgensen

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12

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T. Hansen

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Torsten Lauritzen

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T. Lauritzen

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Knut Borch-Johnsen

8

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K. Borch-Johnsen

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author name string

T. Sparsø

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C. Andreasen

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J. Holmkvist

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G. Andersen

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A. Sandbæk

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publication date

29 April 2009

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52

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7

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1308-1314

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Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels

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https://pubmed.ncbi.nlm.nih.gov/19404609

12 December 2020

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Variation in FTO contributes to childhood obesity and severe adult obesity

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https://pubmed.ncbi.nlm.nih.gov/19404609

12 December 2020

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Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion

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https://pubmed.ncbi.nlm.nih.gov/19404609

12 December 2020

based on heuristic

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Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes

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https://pubmed.ncbi.nlm.nih.gov/19404609

12 December 2020

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Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes

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https://pubmed.ncbi.nlm.nih.gov/19404609

12 December 2020

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Refining the impact of TCF7L2 gene variants on type 2 diabetes and adaptive evolution

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https://pubmed.ncbi.nlm.nih.gov/19404609

12 December 2020

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Post genome-wide association studies of novel genes associated with type 2 diabetes show gene-gene interaction and high predictive value

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https://pubmed.ncbi.nlm.nih.gov/19404609

12 December 2020

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A randomized non-pharmacological intervention study for prevention of ischaemic heart disease: baseline results Inter99.

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https://pubmed.ncbi.nlm.nih.gov/19404609

12 December 2020

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TCF7L2 polymorphisms and progression to diabetes in the Diabetes Prevention Program

1 reference

https://pubmed.ncbi.nlm.nih.gov/19404609

12 December 2020

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The E23K variant of Kir6.2 associates with impaired post-OGTT serum insulin response and increased risk of type 2 diabetes

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https://pubmed.ncbi.nlm.nih.gov/19404609

12 December 2020

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Combining information from common type 2 diabetes risk polymorphisms improves disease prediction

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https://pubmed.ncbi.nlm.nih.gov/19404609

12 December 2020

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A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity

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https://pubmed.ncbi.nlm.nih.gov/19404609

12 December 2020

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Large-scale association studies of variants in genes encoding the pancreatic beta-cell KATP channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) confirm that the KCNJ11 E23K variant is associated with type 2 diabetes

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https://pubmed.ncbi.nlm.nih.gov/19404609

12 December 2020

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Variants in MTNR1B influence fasting glucose levels

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https://pubmed.ncbi.nlm.nih.gov/19404609

12 December 2020

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Studies of the Pro12Ala polymorphism of the peroxisome proliferator-activated receptor-gamma2 (PPAR-gamma2) gene in relation to insulin sensitivity among glucose tolerant caucasians

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https://pubmed.ncbi.nlm.nih.gov/19404609

12 December 2020

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Clinical risk factors, DNA variants, and the development of type 2 diabetes

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https://pubmed.ncbi.nlm.nih.gov/19404609

12 December 2020

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Association testing of novel type 2 diabetes risk alleles in the JAZF1, CDC123/CAMK1D, TSPAN8, THADA, ADAMTS9, and NOTCH2 loci with insulin release, insulin sensitivity, and obesity in a population-based sample of 4,516 glucose-tolerant middle-aged D

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https://pubmed.ncbi.nlm.nih.gov/19404609

12 December 2020

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Impact of polymorphisms in WFS1 on prediabetic phenotypes in a population-based sample of middle-aged people with normal and abnormal glucose regulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/19404609

12 December 2020

based on heuristic

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A variant in CDKAL1 influences insulin response and risk of type 2 diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/19404609

12 December 2020

based on heuristic

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Variants in KCNQ1 are associated with susceptibility to type 2 diabetes mellitus.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19404609

12 December 2020

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The impact of genotype frequencies on the clinical validity of genomic profiling for predicting common chronic diseases

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https://pubmed.ncbi.nlm.nih.gov/19404609

12 December 2020

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Evaluation of Common Variants in the Six Known Maturity-Onset Diabetes of the Young (MODY) Genes for Association With Type 2 Diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/19404609

12 December 2020

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Studies of association of variants near the HHEX, CDKN2A/B, and IGF2BP2 genes with type 2 diabetes and impaired insulin release in 10,705 Danish subjects: validation and extension of genome-wide association studies

1 reference

https://pubmed.ncbi.nlm.nih.gov/19404609

12 December 2020

based on heuristic

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Low physical activity accentuates the effect of the FTO rs9939609 polymorphism on body fat accumulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/19404609

12 December 2020

based on heuristic

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Two variants on chromosome 17 confer prostate cancer risk and the one in TCF2 protects against type 2 diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/19404609

12 December 2020

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A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants

1 reference

https://pubmed.ncbi.nlm.nih.gov/19404609

12 December 2020

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SNPs in KCNQ1 are associated with susceptibility to type 2 diabetes in East Asian and European populations

1 reference

https://pubmed.ncbi.nlm.nih.gov/19404609

12 December 2020

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Assessing the combined impact of 18 common genetic variants of modest effect sizes on type 2 diabetes risk

1 reference

https://pubmed.ncbi.nlm.nih.gov/19404609

12 December 2020

based on heuristic

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A genome-wide association study identifies novel risk loci for type 2 diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/19404609

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Predicting type 2 diabetes based on polymorphisms from genome-wide association studies: a population-based study

1 reference

https://pubmed.ncbi.nlm.nih.gov/19404609

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Testing of diabetes-associated WFS1 polymorphisms in the Diabetes Prevention Program

1 reference

https://pubmed.ncbi.nlm.nih.gov/19404609

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The common PPARgamma Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/19404609

12 December 2020

based on heuristic

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Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/19404609

12 December 2020

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The ADDITION study: proposed trial of the cost-effectiveness of an intensive multifactorial intervention on morbidity and mortality among people with Type 2 diabetes detected by screening

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https://pubmed.ncbi.nlm.nih.gov/19404609

12 December 2020

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G-allele of intronic rs10830963 in MTNR1B confers increased risk of impaired fasting glycemia and type 2 diabetes through an impaired glucose-stimulated insulin release: studies involving 19,605 Europeans

1 reference

https://pubmed.ncbi.nlm.nih.gov/19404609

12 December 2020

based on heuristic

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Common variants in WFS1 confer risk of type 2 diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/19404609

12 December 2020

based on heuristic

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Most rare missense alleles are deleterious in humans: implications for complex disease and association studies

1 reference

https://pubmed.ncbi.nlm.nih.gov/19404609

12 December 2020

based on heuristic

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A variant near MTNR1B is associated with increased fasting plasma glucose levels and type 2 diabetes risk

1 reference

https://pubmed.ncbi.nlm.nih.gov/19404609

12 December 2020

based on heuristic

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Genotype score in addition to common risk factors for prediction of type 2 diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/19404609

12 December 2020

based on heuristic

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10.1007/S00125-009-1362-3

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