(Q55063317)

16 June 2018

title

Mechanism of inhibition of HIV-1 reverse transcriptase by nonnucleoside inhibitors. (English)

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16 June 2018

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R A Spence

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16 June 2018

W M Kati

series ordinal

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16 June 2018

K S Anderson

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16 June 2018

K A Johnson

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16 June 2018

language of work or name

English

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publication date

1 February 1995

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16 June 2018

published in

Science

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16 June 2018

volume

267

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16 June 2018

issue

5200

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16 June 2018

page(s)

988-993

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16 June 2018

Structures of ternary complexes of rat DNA polymerase beta, a DNA template-primer, and ddCTP

cites work

1 reference

12 December 2020

Characterization of the binding site for nevirapine (BI-RG-587), a nonnucleoside inhibitor of human immunodeficiency virus type-1 reverse transcriptase

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12 December 2020

Conformational coupling in DNA polymerase fidelity

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12 December 2020

Resistance to ddI and sensitivity to AZT induced by a mutation in HIV-1 reverse transcriptase

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12 December 2020

Pyridinone derivatives: specific human immunodeficiency virus type 1 reverse transcriptase inhibitors with antiviral activity

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12 December 2020

Molecular targets for AIDS therapy

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12 December 2020

In vitro selection and molecular characterization of human immunodeficiency virus-1 resistant to non-nucleoside inhibitors of reverse transcriptase

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12 December 2020

BI-RG-587 is active against zidovudine-resistant human immunodeficiency virus type 1 and synergistic with zidovudine

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12 December 2020

Nevirapine resistance mutations of human immunodeficiency virus type 1 selected during therapy

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12 December 2020

HIV-1 reverse transcriptase inhibition by a dipyridodiazepinone derivative: BI-RG-587

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12 December 2020

Mutational analysis of two conserved sequence motifs in HIV-1 reverse transcriptase

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12 December 2020

Kinetic partitioning between the exonuclease and polymerase sites in DNA error correction

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12 December 2020

A single conservative amino acid substitution in the reverse transcriptase of human immunodeficiency virus-1 confers resistance to (+)-(5S)-4,5,6,7-tetrahydro-5-methyl-6-(3-methyl-2-butenyl)imidazo[4,5, 1- jk][1,4]benzodiazepin-2(1H)-thione (TIBO R8

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12 December 2020

HIV with reduced sensitivity to zidovudine (AZT) isolated during prolonged therapy

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12 December 2020

Multiple mutations in HIV-1 reverse transcriptase confer high-level resistance to zidovudine (AZT)

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12 December 2020

Inhibition of HIV-1 Replication by a Nonnucleoside Reverse Transcriptase Inhibitor

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12 December 2020

Rapid kinetic analysis of mechanochemical adenosinetriphosphatases.

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12 December 2020

An attempt to unify the structure of polymerases

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12 December 2020

HIV resistance to reverse transcriptase inhibitors

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12 December 2020

Kinetic and mutational analysis of human immunodeficiency virus type 1 reverse transcriptase inhibition by inophyllums, a novel class of non-nucleoside inhibitors

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12 December 2020

An antiviral target on reverse transcriptase of human immunodeficiency virus type 1 revealed by tetrahydroimidazo-[4,5,1-jk] [1,4]benzodiazepin-2 (1H)-one and -thione derivatives

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12 December 2020

Co-expression of the subunits of the heterodimer of HIV-1 reverse transcriptase in Escherichia coli.

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12 December 2020

Human immunodeficiency virus type 1 mutants resistant to nonnucleoside inhibitors of reverse transcriptase arise in tissue culture

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12 December 2020

Crystal structure of human immunodeficiency virus type 1 reverse transcriptase complexed with double-stranded DNA at 3.0 A resolution shows bent DNA

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12 December 2020

Viral resistance to human immunodeficiency virus type 1-specific pyridinone reverse transcriptase inhibitors

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12 December 2020

Site-specific mutagenesis of AIDS virus reverse transcriptase

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12 December 2020

Mechanism and fidelity of HIV reverse transcriptase

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12 December 2020

An induced-fit kinetic mechanism for DNA replication fidelity: direct measurement by single-turnover kinetics

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12 December 2020

Steady-state kinetic studies with the non-nucleoside HIV-1 reverse transcriptase inhibitor U-87201E

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12 December 2020

Clinical pharmacology of 3'-azido-2',3'-dideoxythymidine (zidovudine) and related dideoxynucleosides

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12 December 2020

Inhibition of HIV-1 reverse transcriptase by pyridinone derivatives. Potency, binding characteristics, and effect of template sequence

1 reference

12 December 2020

A mutation in reverse transcriptase of bis(heteroaryl)piperazine-resistant human immunodeficiency virus type 1 that confers increased sensitivity to other nonnucleoside inhibitors

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12 December 2020

Retroviral reverse transcriptase: synthesis, structure, and function

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12 December 2020

3'-Azido-3'-deoxythymidine resistance suppressed by a mutation conferring human immunodeficiency virus type 1 resistance to nonnucleoside reverse transcriptase inhibitors

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12 December 2020

Crystal structure at 3.5 A resolution of HIV-1 reverse transcriptase complexed with an inhibitor

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12 December 2020

A novel dipyridodiazepinone inhibitor of HIV-1 reverse transcriptase acts through a nonsubstrate binding site

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12 December 2020

Kinetic interaction of human immunodeficiency virus type 1 reverse transcriptase with the antiviral tetrahydroimidazo[4,5,1-jk]-[1,4]-benzodiazepine-2-(1H)-thione compound, R82150

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12 December 2020

Complete nucleotide sequence of the AIDS virus, HTLV-III

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12 December 2020

Effect of a thiobenzimidazolone derivative on DNA strand transfer catalyzed by HIV-1 reverse transcriptase

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12 December 2020

HIV-1-specific reverse transcriptase inhibitors show differential activity against HIV-1 mutant strains containing different amino acid substitutions in the reverse transcriptase

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12 December 2020

Potent and selective inhibition of HIV-1 replication in vitro by a novel series of TIBO derivatives

1 reference

12 December 2020

Effect of stage of disease and drug dose on zidovudine susceptibilities of isolates of human immunodeficiency virus

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12 December 2020

Pre-steady-state kinetic analysis of processive DNA replication including complete characterization of an exonuclease-deficient mutant

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12 December 2020

A tetrahedral intermediate in the EPSP synthase reaction observed by rapid quench kinetics

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12 December 2020

Identifiers

DOI

10.1126/SCIENCE.7532321

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16 June 2018

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16 June 2018