(Q54957718)

13 June 2018

title

CRISPR/Cas9 Mediated Disruption of the Swedish APP Allele as a Therapeutic Approach for Early-Onset Alzheimer's Disease. (English)

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13 June 2018

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Bradley T Hyman

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13 June 2018

Martin Ingelsson

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13 June 2018

Xandra O. Breakefield

Xandra O Breakefield

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13 June 2018

Lars Lannfelt

Lars Lannfelt

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13 June 2018

Vilmantas Giedraitis

Vilmantas Giedraitis

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13 June 2018

J. Keith Joung

J Keith Joung

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13 June 2018

Mikołaj P Zaborowski

Mikołaj P Zaborowski

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13 June 2018

author name string

Bence György

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13 June 2018

Camilla Lööv

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13 June 2018

Shuko Takeda

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13 June 2018

Benjamin P Kleinstiver

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13 June 2018

Caitlin Commins

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13 June 2018

Ksenia Kastanenka

1 reference

13 June 2018

Dakai Mu

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13 June 2018

Adrienn Volak

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13 June 2018

Casey A Maguire

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13 June 2018

publication date

16 March 2018

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13 June 2018

Molecular Therapy. Nucleic acids

published in

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13 June 2018

volume

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13 June 2018

page(s)

429-440

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13 June 2018

CRISPR/Cas9 Editing of the Mutant Huntingtin Allele In Vitro and In Vivo

cites work

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16 June 2018

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The antibody aducanumab reduces Aβ plaques in Alzheimer’s disease

16 June 2018

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Ultramicroscopy as a novel tool to unravel the tropism of AAV gene therapy vectors in the brain

16 June 2018

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Increasing the efficiency of precise genome editing with CRISPR-Cas9 by inhibition of nonhomologous end joining

16 June 2018

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In vivo interrogation of gene function in the mammalian brain using CRISPR-Cas9

16 June 2018

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Perspectives on future Alzheimer therapies: amyloid-β protofibrils - a new target for immunotherapy with BAN2401 in Alzheimer's disease

16 June 2018

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16 June 2018

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Development and applications of CRISPR-Cas9 for genome engineering

16 June 2018

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CRISPR-Cas systems for editing, regulating and targeting genomes

16 June 2018

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Improving CRISPR-Cas nuclease specificity using truncated guide RNAs

16 June 2018

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Two phase 3 trials of bapineuzumab in mild-to-moderate Alzheimer's disease

16 June 2018

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Long-term safety and tolerability of ProSavin, a lentiviral vector-based gene therapy for Parkinson's disease: a dose escalation, open-label, phase 1/2 trial.

16 June 2018

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Genome engineering using the CRISPR-Cas9 system

16 June 2018

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DNA targeting specificity of RNA-guided Cas9 nucleases

16 June 2018

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Multiplex genome engineering using CRISPR/Cas systems

16 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5992788

A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline

16 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5992788

Universal real-time PCR for the detection and quantification of adeno-associated virus serotype 2-derived inverted terminal repeat sequences

16 June 2018

1 reference

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Microvesicle-associated AAV vector as a novel gene delivery system

16 June 2018

1 reference

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Concise Review: Human Cell Engineering: Cellular Reprogramming and Genome Editing

16 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5992788

Interference by clustered regularly interspaced short palindromic repeat (CRISPR) RNA is governed by a seed sequence

16 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5992788

Specific AAV serotypes stably transduce primary hippocampal and cortical cultures with high efficiency and low toxicity

16 June 2018

1 reference

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Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene database

16 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5992788

APP locus duplication causes autosomal dominant early-onset Alzheimer disease with cerebral amyloid angiopathy

16 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5992788

Cross-packaging of a single adeno-associated virus (AAV) type 2 vector genome into multiple AAV serotypes enables transduction with broad specificity

16 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5992788

Production of High-Titer Recombinant Adeno-Associated Virus Vectors in the Absence of Helper Adenovirus

16 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5992788

Correlative Memory Deficits, Abeta Elevation, and Amyloid Plaques in Transgenic Mice

16 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5992788

Excessive production of amyloid beta-protein by peripheral cells of symptomatic and presymptomatic patients carrying the Swedish familial Alzheimer disease mutation

16 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5992788

Increased beta-amyloid release and levels of amyloid precursor protein (APP) in fibroblast cell lines from family members with the Swedish Alzheimer's disease APP670/671 mutation.

16 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5992788

Amyloid A4 protein and its precursor in Down's syndrome and Alzheimer's disease.

16 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5992788

A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N-terminus of beta-amyloid

16 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5992788

CRISPR/Cas9-mediated gene editing ameliorates neurotoxicity in mouse model of Huntington's disease

16 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5992788

Phase 3 trials of solanezumab for mild-to-moderate Alzheimer's disease

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5992788

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5992788

CRISPR/Cas9-Correctable mutation-related molecular and physiological phenotypes in iPSC-derived Alzheimer's PSEN2 N141I neurons

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5992788

The genetics of Alzheimer's disease

29 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/29858078

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Exosome-associated AAV vector as a robust and convenient neuroscience tool

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/29858078

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.OMTN.2018.03.007

1 reference

13 June 2018

PMC publication ID

5992788

1 reference

13 June 2018

PubMed publication ID

29858078

1 reference

13 June 2018