(Q54496108)

30 May 2018

title

Potent enantioselective inhibition of DNA-dependent protein kinase (DNA-PK) by atropisomeric chromenone derivatives. (English)

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30 May 2018

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Kate M Clapham

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30 May 2018

Tommy Rennison

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30 May 2018

Gavin Jones

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30 May 2018

Faye Craven

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30 May 2018

Julia Bardos

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30 May 2018

Bernard T Golding

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30 May 2018

Roger J Griffin

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30 May 2018

Karen Haggerty

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30 May 2018

Ian R Hardcastle

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30 May 2018

Pia Thommes

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30 May 2018

Attilla Ting

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30 May 2018

Céline Cano

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30 May 2018

publication date

19 July 2012

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30 May 2018

Organic and Biomolecular Chemistry

published in

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30 May 2018

volume

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30 May 2018

issue

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30 May 2018

page(s)

6747-6757

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30 May 2018

The DNA-damage response in human biology and disease

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The DNA-damage response: new molecular insights and new approaches to cancer therapy

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Sensing and repairing DNA double-strand breaks

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The DNA-dependent protein kinase

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Requirement for the kinase activity of human DNA-dependent protein kinase catalytic subunit in DNA strand break rejoining

21 January 2018

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ATM: from gene to function

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DNA-dependent protein kinase is a molecular target for the development of noncytotoxic radiation-sensitizing drugs

21 January 2018

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Structural Determinants of Phosphoinositide 3-Kinase Inhibition by Wortmannin, LY294002, Quercetin, Myricetin, and Staurosporine

21 January 2018

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Selective benzopyranone and pyrimido[2,1-a]isoquinolin-4-one inhibitors of DNA-dependent protein kinase: synthesis, structure-activity studies, and radiosensitization of a human tumor cell line in vitro.

21 January 2018

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Identification of a highly potent and selective DNA-dependent protein kinase (DNA-PK) inhibitor (NU7441) by screening of chromenone libraries

21 January 2018

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Discovery of potent chromen-4-one inhibitors of the DNA-dependent protein kinase (DNA-PK) using a small-molecule library approach

21 January 2018

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Pyranone, thiopyranone, and pyridone inhibitors of phosphatidylinositol 3-kinase related kinases. Structure-activity relationships for DNA-dependent protein kinase inhibition, and identification of the first potent and selective inhibitor of [...]

21 January 2018

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DNA-Dependent Protein Kinase (DNA-PK) Inhibitors. Synthesis and Biological Activity of Quinolin-4-one and Pyridopyrimidin-4-one Surrogates for the Chromen-4-one Chemotype

21 January 2018

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DNA-dependent protein kinase (DNA-PK) inhibitors: Structure–activity relationships for O-alkoxyphenylchromen-4-one probes of the ATP-binding domain

21 January 2018

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Preclinical evaluation of a potent novel DNA-dependent protein kinase inhibitor NU7441.

21 January 2018

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Atropisomeric 8-arylchromen-4-ones exhibit enantioselective inhibition of the DNA-dependent protein kinase (DNA-PK).

21 January 2018

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The importance of stereoselective determination of drugs in the clinical laboratory

21 January 2018

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Drug disposition in three dimensions: an update on stereoselectivity in pharmacokinetics

21 January 2018

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Stereoselective binding of human serum albumin.

21 January 2018

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The challenge of atropisomerism in drug discovery

21 January 2018

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Atroposelective total synthesis of axially chiral biaryl natural products.

21 January 2018

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Assessing Atropisomer Axial Chirality in Drug Discovery and Development

21 January 2018

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Potent antitumor activity of synthetic 1,2-Naphthoquinones and 1,4-Naphthoquinones

21 January 2018

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Directed ortho metalation. Tertiary amide and O-carbamate directors in synthetic strategies for polysubstituted aromatics

21 January 2018

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The protein kinase complement of the human genome

21 January 2018

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Synthesis of hydroxy- and amino-substituted benzohydroxamic acids: inhibition of ribonucleotide reductase and antitumor activity

21 January 2018

1 reference

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21 January 2018

Identifiers

DOI

10.1039/C2OB26035B

1 reference

30 May 2018

release_d33hsbymtfdubnrij7iezw6hj4

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/d33hsbymtfdubnrij7iezw6hj4

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference

30 May 2018