(Q54153135)

16 June 2018

review article

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title

Novel drug development opportunities for heparin. (English)

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16 June 2018

author name string

Rebecca Lever

series ordinal

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16 June 2018

Clive P Page

series ordinal

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16 June 2018

publication date

1 February 2002

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16 June 2018

Nature Reviews Drug Discovery

published in

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16 June 2018

volume

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16 June 2018

issue

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16 June 2018

page(s)

140-148

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16 June 2018

Heparan sulfate: decoding a dynamic multifunctional cell regulator

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Heparin attenuates TNF-alpha induced inflammatory response through a CD11b dependent mechanism

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Heparin inhibits allergen-induced eosinophil infiltration into guinea-pig lung via a mechanism unrelated to its anticoagulant activity.

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Effect of heparin on antigen-induced airway responses and pulmonary leukocyte accumulation in neonatally immunized rabbits.

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Abnormal mast cells in mice deficient in a heparin-synthesizing enzyme

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Heparin is essential for the storage of specific granule proteases in mast cells

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Renal agenesis in mice homozygous for a gene trap mutation in the gene encoding heparan sulfate 2-sulfotransferase

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Defective heparan sulfate biosynthesis and neonatal lethality in mice lacking N-deacetylase/N-sulfotransferase-1

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Cloning and functional expression of a human heparanase gene

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Identification of active-site residues of the pro-metastatic endoglycosidase heparanase

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31 March 2020

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Characterization of a phosphorylated pentasaccharide isolated from Hansenula holstii NRRL Y-2448 phosphomannan

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31 March 2020

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Soluble complexes of regulated upon activation, normal T cells expressed and secreted (RANTES) and glycosaminoglycans suppress HIV-1 infection but do not induce Ca(2+) signaling

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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Development of oral heparin therapy for prophylaxis and treatment of deep venous thrombosis

31 March 2020

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Single amino acid residues in the E- and P-selectin epidermal growth factor domains can determine carbohydrate binding specificity

31 March 2020

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Oligosaccharides corresponding to the regular sequence of heparin: chemical synthesis and interaction with FGF-2.

31 March 2020

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Selectively desulfated heparin inhibits fibroblast growth factor-induced mitogenicity and angiogenesis

31 March 2020

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Interaction of secretory leukocyte protease inhibitor with heparin inhibits proteases involved in asthma

31 March 2020

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Epithelial coating techniques in the treatment of interstitial cystitis

31 March 2020

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Variation in proteoglycan metabolism by articular chondrocytes in different joint regions is determined by post-natal mechanical loading

31 March 2020

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Effects of AGM-1470 and pentosan polysulphate on tumorigenicity and metastasis of FGF-transfected MCF-7 cells

31 March 2020

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A synthetic pentasaccharide for the prevention of deep-vein thrombosis after total hip replacement

31 March 2020

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Studies on selectin blockers. 7. Structure-activity relationships of sialyl Lewis X mimetics based on modified Ser-Glu dipeptides

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRD724

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16 June 2018

Dimensions Publication ID

1014142020

0 references

1 reference

16 June 2018