(Q53332958)

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Characterization of plasma β-secretase (BACE1) activity and soluble amyloid precursor proteins as potential biomarkers for Alzheimer's disease.

scientific article published on 18 September 2012

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Europe PubMed Central

PubMed publication ID

13 May 2018

http://europepmc.org/abstract/MED/22987781

Characterization of plasma β-secretase (BACE1) activity and soluble amyloid precursor proteins as potential biomarkers for Alzheimer's disease. (English)

1 reference

Europe PubMed Central

PubMed publication ID

13 May 2018

http://europepmc.org/abstract/MED/22987781

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author name string

Guoxin Wu

1

1 reference

Europe PubMed Central

PubMed publication ID

13 May 2018

http://europepmc.org/abstract/MED/22987781

Sethu Sankaranarayanan

2

1 reference

Europe PubMed Central

PubMed publication ID

13 May 2018

http://europepmc.org/abstract/MED/22987781

Jacky Wong

3

1 reference

Europe PubMed Central

PubMed publication ID

13 May 2018

http://europepmc.org/abstract/MED/22987781

Katherine Tugusheva

4

1 reference

Europe PubMed Central

PubMed publication ID

13 May 2018

http://europepmc.org/abstract/MED/22987781

Maria S Michener

5

1 reference

Europe PubMed Central

PubMed publication ID

13 May 2018

http://europepmc.org/abstract/MED/22987781

Xiaoping Shi

6

1 reference

Europe PubMed Central

PubMed publication ID

13 May 2018

http://europepmc.org/abstract/MED/22987781

Jacquelynn J Cook

7

1 reference

Europe PubMed Central

PubMed publication ID

13 May 2018

http://europepmc.org/abstract/MED/22987781

Adam J Simon

8

1 reference

Europe PubMed Central

PubMed publication ID

13 May 2018

http://europepmc.org/abstract/MED/22987781

Mary J Savage

9

1 reference

Europe PubMed Central

PubMed publication ID

13 May 2018

http://europepmc.org/abstract/MED/22987781

publication date

18 September 2012

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Europe PubMed Central

PubMed publication ID

13 May 2018

http://europepmc.org/abstract/MED/22987781

Journal of Neuroscience Research

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Europe PubMed Central

PubMed publication ID

13 May 2018

http://europepmc.org/abstract/MED/22987781

90

1 reference

Europe PubMed Central

PubMed publication ID

13 May 2018

http://europepmc.org/abstract/MED/22987781

12

1 reference

Europe PubMed Central

PubMed publication ID

13 May 2018

http://europepmc.org/abstract/MED/22987781

2247-2258

1 reference

Europe PubMed Central

PubMed publication ID

13 May 2018

http://europepmc.org/abstract/MED/22987781

Is it time for biomarker-based diagnostic criteria for prodromal Alzheimer's disease?

1 reference

https://api.crossref.org/works/10.1002%2FJNR.23122

21 January 2018

Cerebrospinal fluid and plasma biomarkers in Alzheimer disease

1 reference

https://api.crossref.org/works/10.1002%2FJNR.23122

21 January 2018

4-substituted cyclohexyl sulfones as potent, orally active gamma-secretase inhibitors

1 reference

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21 January 2018

Acute gamma-secretase inhibition of nonhuman primate CNS shifts amyloid precursor protein (APP) metabolism from amyloid-beta production to alternative APP fragments without amyloid-beta rebound

1 reference

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21 January 2018

Diagnosis-independent Alzheimer disease biomarker signature in cognitively normal elderly people

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21 January 2018

Decreased cerebrospinal fluid Abeta(42) correlates with brain atrophy in cognitively normal elderly

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21 January 2018

Association of low plasma Abeta42/Abeta40 ratios with increased imminent risk for mild cognitive impairment and Alzheimer disease

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21 January 2018

Evaluation of plasma Abeta(40) and Abeta(42) as predictors of conversion to Alzheimer's disease in patients with mild cognitive impairment

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21 January 2018

Increased beta-Secretase activity in cerebrospinal fluid of Alzheimer's disease subjects.

1 reference

https://api.crossref.org/works/10.1002%2FJNR.23122

21 January 2018

Biomarkers of Alzheimer disease in plasma

1 reference

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21 January 2018

Enhanced clearance of Abeta in brain by sustaining the plasmin proteolysis cascade

1 reference

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21 January 2018

High levels of circulating Abeta42 are sequestered by plasma proteins in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1002%2FJNR.23122

21 January 2018

Decreased α-secretase-cleaved amyloid precursor protein as a diagnostic marker for Alzheimer's diseas

1 reference

https://api.crossref.org/works/10.1002%2FJNR.23122

21 January 2018

Solid-phase extraction enhances detection of beta-amyloid peptides in plasma and enables Abeta quantification following passive immunization with Abeta antibodies

1 reference

https://api.crossref.org/works/10.1002%2FJNR.23122

21 January 2018

Plasma amyloid-beta forms in Alzheimer's disease and non-Alzheimer's disease patients

1 reference

https://api.crossref.org/works/10.1002%2FJNR.23122

21 January 2018

Soluble amyloid precursor proteins in the cerebrospinal fluid as novel potential biomarkers of Alzheimer's disease: a multicenter study.

1 reference

https://api.crossref.org/works/10.1002%2FJNR.23122

21 January 2018

Mice deficient in BACE1, the Alzheimer's beta-secretase, have normal phenotype and abolished beta-amyloid generation

1 reference

https://api.crossref.org/works/10.1002%2FJNR.23122

21 January 2018

Age and diagnostic performance of Alzheimer disease CSF biomarkers.

1 reference

https://api.crossref.org/works/10.1002%2FJNR.23122

21 January 2018

Pittsburgh compound B imaging and prediction of progression from cognitive normality to symptomatic Alzheimer disease

1 reference

https://api.crossref.org/works/10.1002%2FJNR.23122

21 January 2018

BACE1 activity in cerebrospinal fluid and its relation to markers of AD pathology

1 reference

https://api.crossref.org/works/10.1002%2FJNR.23122

21 January 2018

The use of PET in Alzheimer disease

1 reference

https://api.crossref.org/works/10.1002%2FJNR.23122

21 January 2018

Measurement of alpha- and beta-secretase cleaved amyloid precursor protein in cerebrospinal fluid from Alzheimer patients

1 reference

https://api.crossref.org/works/10.1002%2FJNR.23122

21 January 2018

CSF soluble amyloid precursor proteins in the diagnosis of incipient Alzheimer disease.

1 reference

https://api.crossref.org/works/10.1002%2FJNR.23122

21 January 2018

Beta-secretase (BACE) and GSK-3 mRNA levels in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1002%2FJNR.23122

21 January 2018

Quantitative changes in the amyloid βA4 precursor protein in Alzheimer cerebrospinal fluid

1 reference

https://api.crossref.org/works/10.1002%2FJNR.23122

21 January 2018

Increased secreted amyloid precursor protein-α (sAPPα) in severe autism: proposal of a specific, anabolic pathway and putative biomarker

1 reference

https://api.crossref.org/works/10.1002%2FJNR.23122

21 January 2018

In vivo beta-secretase 1 inhibition leads to brain Abeta lowering and increased alpha-secretase processing of amyloid precursor protein without effect on neuregulin-1.

1 reference

https://api.crossref.org/works/10.1002%2FJNR.23122

21 January 2018

First demonstration of cerebrospinal fluid and plasma A beta lowering with oral administration of a beta-site amyloid precursor protein-cleaving enzyme 1 inhibitor in nonhuman primates

1 reference

https://api.crossref.org/works/10.1002%2FJNR.23122

21 January 2018

Measurement of Aβ1-42 in cerebrospinal fluid is influenced by matrix effects.

1 reference

https://api.crossref.org/works/10.1002%2FJNR.23122

21 January 2018

High levels of Alzheimer beta-amyloid precursor protein (APP) in children with severely autistic behavior and aggression

1 reference

https://api.crossref.org/works/10.1002%2FJNR.23122

21 January 2018

Cerebrospinal fluid biomarkers in mild cognitive impairment and dementia

1 reference

https://api.crossref.org/works/10.1002%2FJNR.23122

21 January 2018

Decreased levels of soluble amyloid beta-protein precursor in cerebrospinal fluid of live Alzheimer disease patients

1 reference

https://api.crossref.org/works/10.1002%2FJNR.23122

21 January 2018

Plasma Abeta(1-40) and Abeta(1-42) and the risk of dementia: a prospective case-cohort study.

1 reference

https://api.crossref.org/works/10.1002%2FJNR.23122

21 January 2018

Decrease in age-adjusted cerebrospinal fluid beta-secretase activity in Alzheimer's subjects

1 reference

https://api.crossref.org/works/10.1002%2FJNR.23122

21 January 2018

Decrease in brain soluble amyloid precursor protein β (sAPPβ) in Alzheimer's disease cortex.

1 reference

https://api.crossref.org/works/10.1002%2FJNR.23122

21 January 2018

Pharmacological applications of a novel neoepitope antibody to a modified amyloid precursor protein-derived beta-secretase product

1 reference

https://api.crossref.org/works/10.1002%2FJNR.23122

21 January 2018

Elevated cerebrospinal fluid BACE1 activity in incipient Alzheimer disease

1 reference

https://api.crossref.org/works/10.1002%2FJNR.23122

21 January 2018

Levels of beta-secretase (BACE1) in cerebrospinal fluid as a predictor of risk in mild cognitive impairment

1 reference

https://api.crossref.org/works/10.1002%2FJNR.23122

21 January 2018

CSF amyloid-β 1-38 and 1-42 in FTD and AD: Biomarker performance critically depends on the detergent accessible fraction

1 reference

https://api.crossref.org/works/10.1002%2FJNR.23122

21 January 2018

Identifiers

10.1002/JNR.23122

1 reference

Europe PubMed Central

PubMed publication ID

13 May 2018

http://europepmc.org/abstract/MED/22987781

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

13 May 2018

http://europepmc.org/abstract/MED/22987781

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