(Q53265222)

English

Brain accumulation of sunitinib is restricted by P‐glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) and can be enhanced by oral elacridar and sunitinib coadministration

scientific article published on April 7, 2011

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Europe PubMed Central

PubMed publication ID

12 May 2018

http://europepmc.org/abstract/MED/21351087

Brain accumulation of sunitinib is restricted by P‐glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) and can be enhanced by oral elacridar and sunitinib coadministration (English)

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1 reference

10.1002/IJC.26000

https://api.crossref.org/works/10.1002/IJC.26000

25 November 2024

Brain accumulation of sunitinib is restricted by P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) and can be enhanced by oral elacridar and sunitinib coadministration (English)

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21351087

25 November 2024

7

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Jos H Beijnen

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Europe PubMed Central

PubMed publication ID

12 May 2018

http://europepmc.org/abstract/MED/21351087

author name string

Seng Chuan Tang

1

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Europe PubMed Central

PubMed publication ID

12 May 2018

http://europepmc.org/abstract/MED/21351087

Birk Poller

4

1 reference

Europe PubMed Central

PubMed publication ID

12 May 2018

http://europepmc.org/abstract/MED/21351087

Hilde Rosing

6

1 reference

Europe PubMed Central

PubMed publication ID

12 May 2018

http://europepmc.org/abstract/MED/21351087

Jurjen S. Lagas

2

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21351087

25 November 2024

Nienke A. G. Lankheet

3

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21351087

25 November 2024

Michel J. Hillebrand

5

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21351087

25 November 2024

Jos H. Beijnen

7

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21351087

25 November 2024

Alfred H. Schinkel

8

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21351087

25 November 2024

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publication date

7 April 2011

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Europe PubMed Central

PubMed publication ID

12 May 2018

http://europepmc.org/abstract/MED/21351087

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https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fijc.26000

1 reference

10.1002/IJC.26000

https://api.crossref.org/works/10.1002/IJC.26000

25 November 2024

https://onlinelibrary.wiley.com/doi/pdf/10.1002/ijc.26000

1 reference

10.1002/IJC.26000

https://api.crossref.org/works/10.1002/IJC.26000

25 November 2024

International Journal of Cancer

1 reference

Europe PubMed Central

PubMed publication ID

12 May 2018

http://europepmc.org/abstract/MED/21351087

130

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Europe PubMed Central

PubMed publication ID

12 May 2018

http://europepmc.org/abstract/MED/21351087

1

1 reference

Europe PubMed Central

PubMed publication ID

12 May 2018

http://europepmc.org/abstract/MED/21351087

223-233

1 reference

Europe PubMed Central

PubMed publication ID

12 May 2018

http://europepmc.org/abstract/MED/21351087

The role of ABC transporters in drug resistance, metabolism and toxicity

1 reference

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21 January 2018

Imatinib mesylate (STI571) is a substrate for the breast cancer resistance protein (BCRP)/ABCG2 drug pump

1 reference

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21 January 2018

Distribution of STI-571 to the brain is limited by P-glycoprotein-mediated efflux

1 reference

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21 January 2018

P-glycoprotein and breast cancer resistance protein influence brain distribution of dasatinib

1 reference

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21 January 2018

Kinetic analysis of the cooperation of P-glycoprotein (P-gp/Abcb1) and breast cancer resistance protein (Bcrp/Abcg2) in limiting the brain and testis penetration of erlotinib, flavopiridol, and mitoxantrone

1 reference

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21 January 2018

Brain accumulation of dasatinib is restricted by P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) and can be enhanced by elacridar treatment

1 reference

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21 January 2018

Breast cancer resistance protein and P-glycoprotein limit sorafenib brain accumulation

1 reference

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21 January 2018

The effect of P-gp (Mdr1a/1b), BCRP (Bcrp1) and P-gp/BCRP inhibitors on the in vivo absorption, distribution, metabolism and excretion of imatinib

1 reference

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21 January 2018

An unexpected synergist role of P-glycoprotein and breast cancer resistance protein on the central nervous system penetration of the tyrosine kinase inhibitor lapatinib (N-{3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-[5-({[2-(methylsulfonyl)ethyl]amin

1 reference

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21 January 2018

Distribution of gefitinib to the brain is limited by P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2)-mediated active efflux

1 reference

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21 January 2018

P-Glycoprotein and Breast Cancer Resistance Protein Affect Disposition of Tandutinib, A Tyrosine Kinase Inhibitor

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21 January 2018

Sunitinib: from rational design to clinical efficacy

1 reference

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21 January 2018

Approval summary: sunitinib for the treatment of imatinib refractory or intolerant gastrointestinal stromal tumors and advanced renal cell carcinoma

1 reference

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21 January 2018

Food and Drug Administration drug approval summary: Sunitinib malate for the treatment of gastrointestinal stromal tumor and advanced renal cell carcinoma.

1 reference

https://api.crossref.org/works/10.1002%2FIJC.26000

21 January 2018

Metastatic renal cell carcinoma

1 reference

https://api.crossref.org/works/10.1002%2FIJC.26000

21 January 2018

Long-term survival with metastatic cancer to the brain

1 reference

https://api.crossref.org/works/10.1002%2FIJC.26000

21 January 2018

Sunitinib in patients with metastatic renal cell carcinoma

1 reference

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21 January 2018

Sunitinib versus interferon alfa in metastatic renal-cell carcinoma

1 reference

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21 January 2018

Activity of SU11248, a multitargeted inhibitor of vascular endothelial growth factor receptor and platelet-derived growth factor receptor, in patients with metastatic renal cell carcinoma

1 reference

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21 January 2018

Multicenter, phase II trial of sunitinib in previously treated, advanced non-small-cell lung cancer

1 reference

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21 January 2018

Sensitization of ABCG2-overexpressing cells to conventional chemotherapeutic agent by sunitinib was associated with inhibiting the function of ABCG2.

1 reference

https://api.crossref.org/works/10.1002%2FIJC.26000

21 January 2018

Sunitinib (Sutent, SU11248), a small-molecule receptor tyrosine kinase inhibitor, blocks function of the ATP-binding cassette (ABC) transporters P-glycoprotein (ABCB1) and ABCG2.

1 reference

https://api.crossref.org/works/10.1002%2FIJC.26000

21 January 2018

Interaction of the multikinase inhibitors sorafenib and sunitinib with solute carriers and ATP-binding cassette transporters

1 reference

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21 January 2018

siRNA-mediated knock-down of P-glycoprotein expression reveals distinct cellular disposition of anticancer tyrosine kinases inhibitors

1 reference

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21 January 2018

Multidrug resistance in cancer: role of ATP-dependent transporters

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21 January 2018

Drug export activity of the human canalicular multispecific organic anion transporter in polarized kidney MDCK cells expressing cMOAT (MRP2) cDNA

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21 January 2018

The breast cancer resistance protein protects against a major chlorophyll-derived dietary phototoxin and protoporphyria.

1 reference

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21 January 2018

Human breast cancer resistance protein: interactions with steroid drugs, hormones, the dietary carcinogen 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine, and transport of cimetidine.

1 reference

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21 January 2018

Species-dependent transport and modulation properties of human and mouse multidrug resistance protein 2 (MRP2/Mrp2, ABCC2/Abcc2).

1 reference

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21 January 2018

Absence of the mdr1a P-Glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A.

1 reference

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21 January 2018

Normal viability and altered pharmacokinetics in mice lacking mdr1-type (drug-transporting) P-glycoproteins

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21 January 2018

Contribution of the ABC transporters Bcrp1 and Mdr1a/1b to the side population phenotype in mammary gland and bone marrow of mice

1 reference

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21 January 2018

Single- and multiple-dose disposition kinetics of sunitinib malate, a multitargeted receptor tyrosine kinase inhibitor: comparative plasma kinetics in non-clinical species

1 reference

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21 January 2018

The role of efflux and uptake transporters in [N-{3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-[5-({[2-(methylsulfonyl)ethyl]amino}methyl)-2-furyl]-4-quinazolinamine (GW572016, lapatinib) disposition and drug interactions.

1 reference

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21 January 2018

Rapid and robust transgenic high-grade glioma mouse models for therapy intervention studies

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21 January 2018

Tyrosine kinase inhibitor gefitinib enhances topotecan penetration of gliomas

1 reference

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21 January 2018

Expression, up-regulation, and transport activity of the multidrug-resistance protein Abcg2 at the mouse blood-brain barrier.

1 reference

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21 January 2018

P-glycoprotein and breast cancer resistance protein: two dominant transporters working together in limiting the brain penetration of topotecan

1 reference

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21 January 2018

Bioanalysis and preliminary pharmacokinetics of the acridonecarboxamide derivative GF120918 in plasma of mice and humans by ion-pairing reversed-phase high-performance liquid chromatography with fluorescence detection

36

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10.1002/IJC.26000

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25 November 2024

Complete cerebral response with sunitinib for metastatic renal cell carcinoma

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25 November 2024

Role of breast cancer resistance protein in the bioavailability and fetal penetration of topotecan

42

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Identifiers

10.1002/IJC.26000

1 reference

Europe PubMed Central

PubMed publication ID

12 May 2018

http://europepmc.org/abstract/MED/21351087

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

12 May 2018

http://europepmc.org/abstract/MED/21351087

ResearchGate publication ID

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