(Q52942737)

English

Both IL-12 and IL-18 contribute to small intestinal Th1-type immunopathology following oral infection with Toxoplasma gondii, but IL-12 is dominant over IL-18 in parasite control.

scientific article published in November 2004

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Europe PubMed Central

PubMed publication ID

9 May 2018

http://europepmc.org/abstract/MED/15368276

Both IL-12 and IL-18 contribute to small intestinal Th1-type immunopathology following oral infection with Toxoplasma gondii, but IL-12 is dominant over IL-18 in parasite control. (English)

1 reference

Europe PubMed Central

PubMed publication ID

9 May 2018

http://europepmc.org/abstract/MED/15368276

Toxoplasma gondii

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7

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Europe PubMed Central

PubMed publication ID

9 May 2018

http://europepmc.org/abstract/MED/15368276

Irmgard Förster

10

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Europe PubMed Central

PubMed publication ID

9 May 2018

http://europepmc.org/abstract/MED/15368276

Matthias Lochner

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Matthias Lochner

9

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Cosme Alvarado-Esquivel

3

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Cosme Alvarado-Esquivel

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Europe PubMed Central

PubMed publication ID

9 May 2018

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Anna Vossenkämper

1

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Europe PubMed Central

PubMed publication ID

9 May 2018

http://europepmc.org/abstract/MED/15368276

Daniela Struck

2

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Europe PubMed Central

PubMed publication ID

9 May 2018

http://europepmc.org/abstract/MED/15368276

Tobias Went

4

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Europe PubMed Central

PubMed publication ID

9 May 2018

http://europepmc.org/abstract/MED/15368276

Kioyshi Takeda

5

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Europe PubMed Central

PubMed publication ID

9 May 2018

http://europepmc.org/abstract/MED/15368276

Shizuo Akira

6

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Europe PubMed Central

PubMed publication ID

9 May 2018

http://europepmc.org/abstract/MED/15368276

Gottfried Alber

8

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Europe PubMed Central

PubMed publication ID

9 May 2018

http://europepmc.org/abstract/MED/15368276

Oliver Liesenfeld

11

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Europe PubMed Central

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9 May 2018

http://europepmc.org/abstract/MED/15368276

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publication date

1 November 2004

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Europe PubMed Central

PubMed publication ID

9 May 2018

http://europepmc.org/abstract/MED/15368276

European Journal of Immunology

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Europe PubMed Central

PubMed publication ID

9 May 2018

http://europepmc.org/abstract/MED/15368276

34

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9 May 2018

http://europepmc.org/abstract/MED/15368276

11

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Europe PubMed Central

PubMed publication ID

9 May 2018

http://europepmc.org/abstract/MED/15368276

3197-3207

1 reference

Europe PubMed Central

PubMed publication ID

9 May 2018

http://europepmc.org/abstract/MED/15368276

Association of CD4+ T cell-dependent, interferon-gamma-mediated necrosis of the small intestine with genetic susceptibility of mice to peroral infection with Toxoplasma gondii

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200424993

21 January 2018

TNF-alpha, nitric oxide and IFN-gamma are all critical for development of necrosis in the small intestine and early mortality in genetically susceptible mice infected perorally with Toxoplasma gondii

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200424993

21 January 2018

A dichotomous role for nitric oxide during acute Toxoplasma gondii infection in mice

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200424993

21 January 2018

Oral infection of C57BL/6 mice with Toxoplasma gondii: a new model of inflammatory bowel disease?

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200424993

21 January 2018

Cloning of a new cytokine that induces IFN-gamma production by T cells

1 reference

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21 January 2018

Interleukin-18 regulates both Th1 and Th2 responses

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200424993

21 January 2018

IGIF does not drive Th1 development but synergizes with IL-12 for interferon-gamma production and activates IRAK and NFkappaB.

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200424993

21 January 2018

The costimulatory effect of IL-18 on the induction of antigen-specific IFN-gamma production by resting T cells is IL-12 dependent and is mediated by up-regulation of the IL-12 receptor beta2 subunit.

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200424993

21 January 2018

Role of interleukin-18 in host defense against disseminated Candida albicans infection

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21 January 2018

In vivo antiviral effect of interleukin 18 in a mouse model of vaccinia virus infection

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21 January 2018

Role of interleukin-18 (IL-18) during lethal shock: decreased lipopolysaccharide sensitivity but normal superantigen reaction in IL-18-deficient mice

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200424993

21 January 2018

Anti-interleukin-18 therapy in murine models of inflammatory bowel disease

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200424993

21 January 2018

Interleukin-18 and host defense against infection

1 reference

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21 January 2018

Defective NK cell activity and Th1 response in IL-18-deficient mice

1 reference

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21 January 2018

Infliximab and methotrexate in the treatment of rheumatoid arthritis. Anti-Tumor Necrosis Factor Trial in Rheumatoid Arthritis with Concomitant Therapy Study Group

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21 January 2018

A trial of etanercept, a recombinant tumor necrosis factor receptor:Fc fusion protein, in patients with rheumatoid arthritis receiving methotrexate

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21 January 2018

Tuberculosis associated with infliximab, a tumor necrosis factor alpha-neutralizing agent

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200424993

21 January 2018

Mice deficient for the 55 kd tumor necrosis factor receptor are resistant to endotoxic shock, yet succumb to L. monocytogenes infection

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200424993

21 January 2018

Generation of neutralizing mouse anti-mouse IL-18 antibodies for inhibition of inflammatory responses in vivo

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200424993

21 January 2018

IL-10 is required for prevention of necrosis in the small intestine and mortality in both genetically resistant BALB/c and susceptible C57BL/6 mice following peroral infection with Toxoplasma gondii

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200424993

7 January 2021

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Lamina propria CD4+ T lymphocytes synergize with murine intestinal epithelial cells to enhance proinflammatory response against an intracellular pathogen

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200424993

7 January 2021

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Chlamydia trachomatis infection of epithelial cells induces the activation of caspase-1 and release of mature IL-18.

1 reference

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7 January 2021

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Interleukin-18 protects mice against acute herpes simplex virus type 1 infection.

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200424993

7 January 2021

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Genetically resistant mice lacking IL-18 gene develop Th1 response and control cutaneous Leishmania major infection

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200424993

7 January 2021

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IL-12-independent IFN-gamma production by T cells in experimental Chagas' disease is mediated by IL-18.

1 reference

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7 January 2021

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IL-18 contributes to host resistance against infection with Pseudomonas aeruginosa through induction of IFN-gamma production

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200424993

7 January 2021

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IL-18 improves the early antimicrobial host response to pneumococcal pneumonia

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200424993

7 January 2021

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Reduced Incidence and Severity of Collagen-Induced Arthritis in Mice Lacking IL-18

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200424993

7 January 2021

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A Proinflammatory Role of IL-18 in the Development of Spontaneous Autoimmune Disease

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200424993

7 January 2021

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Macrophage-derived IL-18-mediated intestinal inflammation in the murine model of Crohn's disease

1 reference

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7 January 2021

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Neutralization of interleukin-18 reduces severity in murine colitis and intestinal IFN-gamma and TNF-alpha production

1 reference

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Treatment of T cell-dependent experimental colitis in SCID mice by local administration of an adenovirus expressing IL-18 antisense mRNA.

1 reference

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7 January 2021

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Contribution of IL-18 to Th1 response and host defense against infection by Mycobacterium tuberculosis: a comparative study with IL-12p40

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200424993

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Regulation and function of T-cell-mediated immunity during Toxoplasma gondii infection.

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200424993

7 January 2021

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Interferon-gamma: the major mediator of resistance against Toxoplasma gondii

1 reference

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7 January 2021

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Functional reconstitution and regulation of IL-18 activity by the IL-18R beta chain

1 reference

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7 January 2021

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A protective and agonistic function of IL-12p40 in mycobacterial infection.

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Toxoplasma gondii infection of the central nervous system. Use of the peroxidase-antiperoxidase method to demonstrate toxoplasma in formalin fixed, paraffin embedded tissue sections

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Identifiers

10.1002/EJI.200424993

1 reference

Europe PubMed Central

PubMed publication ID

9 May 2018

http://europepmc.org/abstract/MED/15368276

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

9 May 2018

http://europepmc.org/abstract/MED/15368276

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