(Q51836310)

English

Amyloid precursor protein associates with a nicastrin-dependent docking site on the presenilin 1-gamma-secretase complex in cells demonstrated by fluorescence lifetime imaging.

scientific article published in June 2003

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scholarly article

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12805296%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

Amyloid precursor protein associates with a nicastrin-dependent docking site on the presenilin 1-gamma-secretase complex in cells demonstrated by fluorescence lifetime imaging (English)

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12805296%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

3

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12805296%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

author name string

Oksana Berezovska

1

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12805296%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

Pavan Ramdya

2

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12805296%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

Michael S Wolfe

4

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12805296%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

Brian J Bacskai

5

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12805296%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

Bradley T Hyman

6

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Europe PubMed Central

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4 November 2019

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1 June 2003

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Europe PubMed Central

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4 November 2019

Journal of Neuroscience

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12805296%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

23

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Europe PubMed Central

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4 November 2019

11

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Europe PubMed Central

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4 November 2019

4560-4566

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12805296%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805296

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The presenilins in Alzheimer's disease--proteolysis holds the key.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805296

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Membrane association and protein conformation of alpha-synuclein in intact neurons. Effect of Parkinson's disease-linked mutations

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805296

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutation of conserved aspartates affects maturation of both aspartate mutant and endogenous presenilin 1 and presenilin 2 complexes

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805296

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805296

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805296

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Aspartate mutations in presenilin and gamma-secretase inhibitors both impair notch1 proteolysis and nuclear translocation with relative preservation of notch1 signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805296

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Presenilin-1 and -2 are molecular targets for gamma-secretase inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805296

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Presenilin complexes with the C-terminal fragments of amyloid precursor protein at the sites of amyloid beta-protein generation

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805296

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805296

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Functional gamma-secretase inhibitors reduce beta-amyloid peptide levels in brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805296

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Presenilin-1 binds cytoplasmic epithelial cadherin, inhibits cadherin/p120 association, and regulates stability and function of the cadherin/catenin adhesion complex

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805296

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of PS1 deficiency and an APP gamma-secretase inhibitor on Notch1 signaling in primary mammalian neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805296

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The discrepancy between presenilin subcellular localization and gamma-secretase processing of amyloid precursor protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805296

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Presenilin, Notch, and the genesis and treatment of Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805296

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Demonstration by fluorescence resonance energy transfer of two sites of interaction between the low-density lipoprotein receptor-related protein and the amyloid precursor protein: role of the intracellular adapter protein Fe65.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805296

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

gamma -Secretase cleavage and nuclear localization of ErbB-4 receptor tyrosine kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805296

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Presenilin-dependent gamma-secretase-like intramembrane cleavage of ErbB4.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805296

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

APH-1 is a multipass membrane protein essential for the Notch signaling pathway in Caenorhabditis elegans embryos

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805296

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activity-dependent isolation of the presenilin- gamma -secretase complex reveals nicastrin and a gamma substrate

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805296

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Proteolytic processing of low density lipoprotein receptor-related protein mediates regulated release of its intracellular domain

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805296

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A presenilin-1/gamma-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctions

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805296

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Presenilin and nicastrin regulate each other and determine amyloid beta-peptide production via complex formation

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805296

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Linear non-competitive inhibition of solubilized human gamma-secretase by pepstatin A methylester, L685458, sulfonamides, and benzodiazepines

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805296

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805296

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gamma-secretase/presenilin inhibitors for Alzheimer's disease phenocopy Notch mutations in Drosophila.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805296

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fluorescence resonance energy transfer determinations using multiphoton fluorescence lifetime imaging microscopy to characterize amyloid-beta plaques

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805296

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Beta-amyloid precursor protein of Alzheimer disease occurs as 110- to 135-kilodalton membrane-associated proteins in neural and nonneural tissues.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805296

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interaction between amyloid precursor protein and presenilins in mammalian cells: Implications for the pathogenesis of Alzheimer disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805296

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805296

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.23-11-04560.2003

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12805296%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12805296%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12805296%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

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