(Q49146450)

18 February 2018

title

DNA damage in brain mitochondria caused by aging and MPTP treatment (English)

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18 February 2018

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Mandavilli BS

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18 February 2018

Ali SF

series ordinal

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18 February 2018

Van Houten B

series ordinal

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18 February 2018

language of work or name

English

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publication date

1 December 2000

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18 February 2018

published in

Brain Research

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18 February 2018

volume

885

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18 February 2018

issue

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18 February 2018

page(s)

45-52

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18 February 2018

MPP+ and MPDP+ induced oxygen radical formation with mitochondrial enzymes.

cites work

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2800%2902926-7

MPTP-induced oxidative stress and neurotoxicity are age-dependent: evidence from measures of reactive oxygen species and striatal dopamine levels

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2800%2902926-7

Oxidative DNA Damage in the Parkinsonian Brain: An Apparent Selective Increase in 8‐Hydroxyguanine Levels in Substantia Nigra

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2800%2902926-7

Hydrogen peroxide causes significant mitochondrial DNA damage in human RPE cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2800%2902926-7

The cellular production of hydrogen peroxide

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2800%2902926-7

Elevated reactive oxygen species and antioxidant enzyme activities in animal and cellular models of Parkinson's disease

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2800%2902926-7

Rapid ATP loss caused by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in mouse brain

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2800%2902926-7

2-deoxyglucose enhances 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced ATP loss in the mouse brain.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2800%2902926-7

Irreversible inhibition of mitochondrial complex I by 1-methyl-4-phenylpyridinium: evidence for free radical involvement

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2800%2902926-7

Modelling the effects of age-related mtDNA mutation accumulation; Complex I deficiency, superoxide and cell death

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2800%2902926-7

Chronic parkinsonism secondary to intravenous injection of meperidine analogues

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2800%2902926-7

Bcl-2 facilitates recovery from DNA damage after oxidative stress

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2800%2902926-7

MPP(+)-induced neurotoxicity in mouse is age-dependent: evidenced by the selective inhibition of complexes of electron transport

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2800%2902926-7

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and 1-methyl-4-phenylpyridine (MPP+) cause rapid ATP depletion in isolated hepatocytes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2800%2902926-7

Mitochondrial DNA and Parkinson's disease

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2800%2902926-7

Prospects for new restorative and neuroprotective treatments in Parkinson's disease

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2800%2902926-7

The oxidant stress hypothesis in Parkinson's disease: evidence supporting it

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2800%2902926-7

MPTP- and MPP(+)-induced effects on body temperature exhibit age- and strain-dependence in mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2800%2902926-7

The dopamine-depleting effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in CD-1 mice are gender-dependent

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2800%2902926-7

Superoxide radical and superoxide dismutases

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2800%2902926-7

Analysis of oxygen consumption and mitochondrial permeability with age in mice.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2800%2902926-7

Aging: a theory based on free radical and radiation chemistry

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2800%2902926-7

The biologic clock: the mitochondria?

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2800%2902926-7

Protection against the dopaminergic neurotoxicity of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine by monoamine oxidase inhibitors

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2800%2902926-7

Differential neurotoxicity of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in Swiss-Webster mice from different sources

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2800%2902926-7

DNA oxidation matters: The HPLC–electrochemical detection assay of 8-oxo-deoxyguanosine and 8-oxo-guanine

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2800%2902926-7

Parkinsonism-inducing neurotoxin, N-methyl-4-phenyl-1,2,3,6 -tetrahydropyridine: uptake of the metabolite N-methyl-4-phenylpyridine by dopamine neurons explains selective toxicity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2800%2902926-7

Oxidative damage in neurodegenerative disease

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2800%2902926-7

Mitochondrial mutations, cellular instability and ageing: modelling the population dynamics of mitochondria.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2800%2902926-7

Chronic Parkinsonism in humans due to a product of meperidine-analog synthesis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2800%2902926-7

The biotransformation of MPTP and disposition of MPP+: the effects of aging

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2800%2902926-7

Mitochondrial DNA mutations as an important contributor to ageing and degenerative diseases

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2800%2902926-7

Oxidative damage to mitochondrial DNA is increased in Alzheimer's disease

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2800%2902926-7

Oxidative damage to mitochondrial DNA shows marked age-dependent increases in human brain.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2800%2902926-7

Mitochondrial role in cell aging

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2800%2902926-7

Administration of MPTP acutely increases glucose utilization in the substantia nigra of primates.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2800%2902926-7

Transgenic mice with increased Cu/Zn-superoxide dismutase activity are resistant to N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2800%2902926-7

Normal oxidative damage to mitochondrial and nuclear DNA is extensive

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2800%2902926-7

Oxidative damage to mitochondrial DNA and its relationship to ageing

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2800%2902926-7

Preferential mitochondrial DNA injury caused by glucose oxidase as a steady generator of hydrogen peroxide in human fibroblasts

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2800%2902926-7

Repair of DNA damage in mitochondria

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2800%2902926-7

Effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and 1-methyl-4-phenylpyridinium ion on ATP levels of mouse brain synaptosomes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2800%2902926-7

Mitochondrial function in neurodegeneration and ageing

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2800%2902926-7

Astrocyte mitochondria: a substrate for iron deposition in the aging rat substantia nigra

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2800%2902926-7

Aging, cytochrome oxidase activity, and hydrogen peroxide release by mitochondria.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2800%2902926-7

Intense oxidative DNA damage promoted by L-dopa and its metabolites. Implications for neurodegenerative disease

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2800%2902926-7

Superoxide-dependent depletion of reduced glutathione by L-DOPA and dopamine. Relevance to Parkinsonʼs disease

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2800%2902926-7

Partial protective effect of MK-801 on MPTP-induced reduction of striatal dopamine in mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2800%2902926-7

NADH- and NADPH-dependent lipid peroxidation in bovine heart submitochondrial particles. Dependence on the rate of electron flow in the respiratory chain and an antioxidant role of ubiquinol

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2800%2902926-7

NADH- and NADPH-dependent formation of superoxide anions by bovine heart submitochondrial particles and NADH–ubiquinone reductase preparation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2800%2902926-7

Apoptosis in neurodegenerative diseases: the role of mitochondria

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2800%2902926-7

Mitochondrial DNA damage is more extensive and persists longer than nuclear DNA damage in human cells following oxidative stress

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2800%2902926-7

dATP causes specific release of cytochrome C from mitochondria

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2800%2902926-7

Parkinson's disease is associated with oxidative damage to cytoplasmic DNA and RNA in substantia nigra neurons

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2800%2902926-7

10.1016/S0006-8993(00)02926-7

7 January 2021

Identifiers

DOI

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18 February 2018

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18 February 2018