(Q48915342)

English

Enhanced amyloidogenic processing of the beta-amyloid precursor protein in gene-targeted mice bearing the Swedish familial Alzheimer's disease mutations and a "humanized" Abeta sequence

scientific article published in September 1996

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scholarly article

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Europe PubMed Central

PubMed publication ID

16 February 2018

http://europepmc.org/abstract/MED/8798542

Enhanced amyloidogenic processing of the beta-amyloid precursor protein in gene-targeted mice bearing the Swedish familial Alzheimer's disease mutations and a "humanized" Abeta sequence (English)

1 reference

Europe PubMed Central

PubMed publication ID

16 February 2018

http://europepmc.org/abstract/MED/8798542

Alzheimer's disease

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author name string

Reaume AG

1

1 reference

Europe PubMed Central

PubMed publication ID

16 February 2018

http://europepmc.org/abstract/MED/8798542

Howland DS

2

1 reference

Europe PubMed Central

PubMed publication ID

16 February 2018

http://europepmc.org/abstract/MED/8798542

Trusko SP

3

1 reference

Europe PubMed Central

PubMed publication ID

16 February 2018

http://europepmc.org/abstract/MED/8798542

Savage MJ

4

1 reference

Europe PubMed Central

PubMed publication ID

16 February 2018

http://europepmc.org/abstract/MED/8798542

Lang DM

5

1 reference

Europe PubMed Central

PubMed publication ID

16 February 2018

http://europepmc.org/abstract/MED/8798542

Greenberg BD

6

1 reference

Europe PubMed Central

PubMed publication ID

16 February 2018

http://europepmc.org/abstract/MED/8798542

Siman R

7

1 reference

Europe PubMed Central

PubMed publication ID

16 February 2018

http://europepmc.org/abstract/MED/8798542

Scott RW

8

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Europe PubMed Central

PubMed publication ID

16 February 2018

http://europepmc.org/abstract/MED/8798542

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publication date

1 September 1996

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Europe PubMed Central

PubMed publication ID

16 February 2018

http://europepmc.org/abstract/MED/8798542

Journal of Biological Chemistry

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Europe PubMed Central

PubMed publication ID

16 February 2018

http://europepmc.org/abstract/MED/8798542

271

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Europe PubMed Central

PubMed publication ID

16 February 2018

http://europepmc.org/abstract/MED/8798542

38

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Europe PubMed Central

PubMed publication ID

16 February 2018

http://europepmc.org/abstract/MED/8798542

23380-23388

1 reference

Europe PubMed Central

PubMed publication ID

16 February 2018

http://europepmc.org/abstract/MED/8798542

The molecular pathology of Alzheimer's disease

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Characterization and chromosomal localization of a cDNA encoding brain amyloid of Alzheimer's disease

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The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

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A new A4 amyloid mRNA contains a domain homologous to serine proteinase inhibitors

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Novel precursor of Alzheimer's disease amyloid protein shows protease inhibitory activity

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Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein

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Amyloid plaque core protein in Alzheimer disease and Down syndrome

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Cleavage of amyloid beta peptide during constitutive processing of its precursor

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Exact cleavage site of Alzheimer amyloid precursor in neuronal PC-12 cells

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Secretion of β-amyloid precursor protein cleaved at the amino terminus of the β-amyloid peptide

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Amyloid beta-peptide is produced by cultured cells during normal metabolism

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Isolation and quantification of soluble Alzheimer's beta-peptide from biological fluids

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Amyloid A4 protein and its precursor in Down's syndrome and Alzheimer's disease.

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Occurrence of neuropathological changes and dementia of Alzheimer's disease in Down's syndrome

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The pathological association between Down syndrome and Alzheimer disease

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Early-onset Alzheimer's disease caused by mutations at codon 717 of the beta-amyloid precursor protein gene

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Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease

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Mis-sense mutation Val&rarr;Ile in exon 17 of amyloid precursor protein gene in Japanese familial Alzheimer's disease

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A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N-terminus of beta-amyloid

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21 January 2018

Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-protein production

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21 January 2018

Release of excess amyloid beta protein from a mutant amyloid beta protein precursor.

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21 January 2018

An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (beta APP717) mutants.

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21 January 2018

Excessive production of amyloid beta-protein by peripheral cells of symptomatic and presymptomatic patients carrying the Swedish familial Alzheimer disease mutation

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21 January 2018

Formation of beta-amyloid protein deposits in brains of transgenic mice

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21 January 2018

Transgenic mice expressing human beta-APP751, but not mice expressing beta-APP695, display early Alzheimer's disease-like histopathology

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21 January 2018

Age-related CNS disorder and early death in transgenic FVB/N mice overexpressing Alzheimer amyloid precursor proteins

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21 January 2018

Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein

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21 January 2018

Expression of the human beta-amyloid precursor protein gene from a yeast artificial chromosome in transgenic mice

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21 January 2018

Introduction and expression of the 400 kilobase amyloid precursor protein gene in transgenic mice [corrected]

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21 January 2018

Deposition of beta/A4 immunoreactivity and neuronal pathology in transgenic mice expressing the carboxyl-terminal fragment of the Alzheimer amyloid precursor in the brain

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21 January 2018

The Alzheimer's A beta peptide induces neurodegeneration and apoptotic cell death in transgenic mice

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21 January 2018

Levels and alternative splicing of amyloid beta protein precursor (APP) transcripts in brains of APP transgenic mice and humans with Alzheimer's disease

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Evidence for excitoprotective and intraneuronal calcium-regulating roles for secreted forms of the beta-amyloid precursor protein

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21 January 2018

Cardiac malformation in neonatal mice lacking connexin43.

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Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene

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Derivation of completely cell culture-derived mice from early-passage embryonic stem cells

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Simple and efficient production of embryonic stem cell-embryo chimeras by coculture

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Cathepsin G: localization in human cerebral cortex and generation of amyloidogenic fragments from the beta-amyloid precursor protein

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A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

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Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

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Complementary DNA for the mouse homolog of the human amyloid beta protein precursor

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Genomic organization of the human amyloid beta-protein precursor gene

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Altering the genome by homologous recombination

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Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes

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Study of the synthesis and secretion of normal and artificial mutants of murine amyloid precursor protein (APP): cleavage of APP occurs in a late compartment of the default secretion pathway

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Beta-amyloid precursor protein cleavage by a membrane-bound protease

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Generation of beta-amyloid in the secretory pathway in neuronal and nonneuronal cells

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Basolateral secretion of amyloid precursor protein in Madin-Darby canine kidney cells is disturbed by alterations of intracellular pH and by introducing a mutation associated with familial Alzheimer's disease

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Protein phosphorylation inhibits production of Alzheimer amyloid beta/A4 peptide

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Metabolism of the "Swedish" amyloid precursor protein variant in neuro2a (N2a) cells. Evidence that cleavage at the "beta-secretase" site occurs in the golgi apparatus

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Amyloid precursor protein secretion and beta A4 amyloid generation are not mutually exclusive

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Intracellular production of beta A4 amyloid of Alzheimer's disease: modulation by phosphoramidon and lack of coupling to the secretion of the amyloid precursor protein

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Human and rodent Alzheimer beta-amyloid peptides acquire distinct conformations in membrane-mimicking solvents

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Rapid induction of Alzheimer A beta amyloid formation by zinc.

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Amyloidogenicity of rodent and human beta A4 sequences

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Identifiers

10.1074/JBC.271.38.23380

1 reference

Europe PubMed Central

PubMed publication ID

16 February 2018

http://europepmc.org/abstract/MED/8798542

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

16 February 2018

http://europepmc.org/abstract/MED/8798542

ResearchGate publication ID

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