(Q48974747)

English

Insulin-like growth factor-I overexpression attenuates cerebellar apoptosis by altering the expression of Bcl family proteins in a developmentally specific manner.

scientific article published in March 2001

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11222638%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

Insulin-like growth factor-I overexpression attenuates cerebellar apoptosis by altering the expression of Bcl family proteins in a developmentally specific manner (English)

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11222638%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

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inferred from title

1 reference

based on heuristic

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author name string

D Chrysis

1

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11222638%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

A S Calikoglu

2

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11222638%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

P Ye

3

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11222638%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

A J D'Ercole

4

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11222638%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

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publication date

1 March 2001

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Europe PubMed Central

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4 November 2019

Journal of Neuroscience

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11222638%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

21

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11222638%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

5

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11222638%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

1481-1489

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11222638%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt

1 reference

https://pubmed.ncbi.nlm.nih.gov/11222638

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bax deletion further orders the cell death pathway in cerebellar granule cells and suggests a caspase-independent pathway to cell death.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11222638

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vivo actions of insulin-like growth factor-I (IGF-I) on brain myelination: studies of IGF-I and IGF binding protein-1 (IGFBP-1) transgenic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/11222638

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interactions between bcl-2 and the IGF system control apoptosis in the developing mouse brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/11222638

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin-like growth factor I protects oligodendrocytes from tumor necrosis factor-alpha-induced injury

1 reference

https://pubmed.ncbi.nlm.nih.gov/11222638

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Maturation-dependent modulation of apoptosis in cultured cerebellar granule neurons by cytokines and neurotrophins

1 reference

https://pubmed.ncbi.nlm.nih.gov/11222638

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin-like growth factor I rescues SH-SY5Y human neuroblastoma cells from hyperosmotic induced programmed cell death

1 reference

https://pubmed.ncbi.nlm.nih.gov/11222638

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurodegeneration in Lurcher mice occurs via multiple cell death pathways

1 reference

https://pubmed.ncbi.nlm.nih.gov/11222638

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bcl-2 affects survival but not neuronal differentiation of PC12 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/11222638

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death

1 reference

https://pubmed.ncbi.nlm.nih.gov/11222638

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of insulin-like growth factors in embryonic and postnatal growth

1 reference

https://pubmed.ncbi.nlm.nih.gov/11222638

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bax promotes neuronal cell death and is downregulated during the development of the nervous system.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11222638

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction of apoptosis in cerebellar granule neurons by low potassium: inhibition of death by insulin-like growth factor I and cAMP.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11222638

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Overexpression of BCL-2 in transgenic mice protects neurons from naturally occurring cell death and experimental ischemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/11222638

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin-like growth factor-1 attenuates apoptosis in hippocampal neurons caused by cerebral ischemia and reperfusion in stroke-prone spontaneously hypertensive rats.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11222638

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of components of the ubiquitin system by insulin-like growth factor I and growth hormone in skeletal muscle of rats made catabolic with dexamethasone

1 reference

https://pubmed.ncbi.nlm.nih.gov/11222638

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antiapoptotic signalling by the insulin-like growth factor I receptor, phosphatidylinositol 3-kinase, and Akt.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11222638

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin-like growth factor I prevents the development of sensitivity to kainate neurotoxicity in cerebellar granule cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/11222638

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin-like growth factor-1 inhibition of apoptosis is associated with increased expression of the bcl-xL gene product

1 reference

https://pubmed.ncbi.nlm.nih.gov/11222638

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

1 reference

https://pubmed.ncbi.nlm.nih.gov/11222638

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bax inactivation in lurcher mutants rescues cerebellar granule cells but not purkinje cells or inferior olivary neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/11222638

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Massive cell death of immature hematopoietic cells and neurons in Bcl-x-deficient mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/11222638

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selective neuroprotective effects with insulin-like growth factor-1 in phenotypic striatal neurons following ischemic brain injury in fetal sheep.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11222638

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased cerebellar Purkinje cell numbers in mice overexpressing a human bcl-2 transgene

1 reference

https://pubmed.ncbi.nlm.nih.gov/11222638

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death

1 reference

https://pubmed.ncbi.nlm.nih.gov/11222638

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reduction of ischemic brain injury by topical application of insulin-like growth factor-I after transient middle cerebral artery occlusion in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/11222638

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

bcl-x is expressed in embryonic and postnatal neural tissues and functions to prevent neuronal cell death

1 reference

https://pubmed.ncbi.nlm.nih.gov/11222638

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inactivation of bcl-2 results in progressive degeneration of motoneurons, sympathetic and sensory neurons during early postnatal development

1 reference

https://pubmed.ncbi.nlm.nih.gov/11222638

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dual function for poly(ADP-ribose) synthesis in response to DNA strand breakage

1 reference

https://pubmed.ncbi.nlm.nih.gov/11222638

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r)

1 reference

https://pubmed.ncbi.nlm.nih.gov/11222638

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of neuronal survival by the serine-threonine protein kinase Akt

1 reference

https://pubmed.ncbi.nlm.nih.gov/11222638

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Suppression of interleukin-1 beta-converting enzyme-mediated cell death by insulin-like growth factor

1 reference

https://pubmed.ncbi.nlm.nih.gov/11222638

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Uptake of circulating insulin-like growth factor-I into the cerebrospinal fluid of normal and diabetic rats and normalization of IGF-II mRNA content in diabetic rat brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/11222638

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Decreased IGF-I gene expression during the apoptosis of Purkinje cells in pcd mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/11222638

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of Bcl-2 in the brain-derived neurotrophic factor survival response

1 reference

https://pubmed.ncbi.nlm.nih.gov/11222638

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin-like growth factor I increases brain growth and central nervous system myelination in transgenic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/11222638

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

bcl-2 transgene expression can protect neurons against developmental and induced cell death

1 reference

https://pubmed.ncbi.nlm.nih.gov/11222638

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Upregulation of bax protein levels in neurons following cerebral ischemia.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11222638

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin-like Growth Factor 1 Inhibits Apoptosis Using the Phosphatidylinositol 3′-Kinase and Mitogen-activated Protein Kinase Pathways

1 reference

https://pubmed.ncbi.nlm.nih.gov/11222638

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The effects of insulin-like growth factor (IGF)-1, IGF-2, and des-IGF-1 on neuronal loss after hypoxic-ischemic brain injury in adult rats: evidence for a role for IGF binding proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/11222638

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Correlation between insulin-like growth factor (IGF)-binding protein 5 and IGF-I gene expression during brain development.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11222638

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interaction of poly(ADP-ribose)polymerase with DNA polymerase alpha

1 reference

https://pubmed.ncbi.nlm.nih.gov/11222638

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

bcl-xLx is the major bcl-x mRNA form expressed during murine development and its product localizes to mitochondria

1 reference

https://pubmed.ncbi.nlm.nih.gov/11222638

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of the insulin-like growth factors in the central nervous system

1 reference

https://pubmed.ncbi.nlm.nih.gov/11222638

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bax deficiency prevents the increased cell death of immature neurons in bcl-x-deficient mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/11222638

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased inferior olivary neuron and cerebellar granule cell numbers in transgenic mice overexpressing the human Bcl-2 gene

1 reference

https://pubmed.ncbi.nlm.nih.gov/11222638

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin-like growth factor-1 is a potent neuronal rescue agent after hypoxic-ischemic injury in fetal lambs

1 reference

https://pubmed.ncbi.nlm.nih.gov/11222638

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin-like growth factor-I induces bcl-2 promoter through the transcription factor cAMP-response element-binding protein.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11222638

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Up-regulation of bax and down-regulation of bc1–2 is associated with kainate-induced apoptosis in mouse brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/11222638

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of fasting on insulin receptor-related receptor messenger ribonucleic acid in rat kidney.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11222638

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of the IGF-I receptor in apoptosis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11222638

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vivo actions of insulin-like growth factor-I (IGF-I) on cerebellum development in transgenic mice: evidence that IGF-I increases proliferation of granule cell progenitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/11222638

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Type I insulin-like growth factor receptor activation regulates apoptotic proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/11222638

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In situ labeling of granule cells for apoptosis-associated DNA fragmentation reveals different mechanisms of cell loss in developing cerebellum

1 reference

https://pubmed.ncbi.nlm.nih.gov/11222638

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Electron microscopic analysis of postnatal histogenesis in the cerebellar cortex of staggerer mutant mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/11222638

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The proto-oncogene bcl-2 can selectively rescue neurotrophic factor-dependent neurons from apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/11222638

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IL-4 and insulin-like growth factor-I inhibit the decline in Bcl-2 and promote the survival of IL-3-deprived myeloid progenitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/11222638

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.21-05-01481.2001

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11222638%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11222638%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11222638%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

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