(Q48654126)

English

Selective Destruction of Stable Microtubules and Axons by Inhibitors of Protein Serine/Threonine Phosphatases in Cultured Human Neurons (NT2N Cells)

scientific article published on August 1, 1997

In more languages

default for all languages

No label defined

No description defined

Statements

scholarly article

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9221771%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

Selective destruction of stable microtubules and axons by inhibitors of protein serine/threonine phosphatases in cultured human neurons (English)

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9221771%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

Selective Destruction of Stable Microtubules and Axons by Inhibitors of Protein Serine/Threonine Phosphatases in Cultured Human Neurons (NT2N Cells) (English)

1 reference

10.1523/JNEUROSCI.17-15-05726.1997

https://api.crossref.org/works/10.1523/JNEUROSCI.17-15-05726.1997

6 November 2024

author name string

S. E. Merrick

1

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A9221771

6 November 2024

J. Q. Trojanowski

2

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A9221771

6 November 2024

V. M. Lee

3

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A9221771

6 November 2024

language of work or name

0 references

publication date

1 August 1997

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9221771%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

full work available at URL

https://www.jneurosci.org/content/jneuro/17/15/5726.full.pdf

Portable Document Format

online access status

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A9221771

6 November 2024

http://www.jneurosci.org/cgi/content/abstract/17/15/5726

online access status

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A9221771

6 November 2024

https://europepmc.org/articles/PMC6573204

online access status

content deliverer

Europe PubMed Central

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A9221771

6 November 2024

https://europepmc.org/articles/PMC6573204?pdf=render

Portable Document Format

online access status

content deliverer

Europe PubMed Central

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A9221771

6 November 2024

https://doi.org/10.1523/jneurosci.17-15-05726.1997

online access status

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A9221771

6 November 2024

https://syndication.highwire.org/content/doi/10.1523/JNEUROSCI.17-15-05726.1997

1 reference

10.1523/JNEUROSCI.17-15-05726.1997

https://api.crossref.org/works/10.1523/JNEUROSCI.17-15-05726.1997

6 November 2024

Journal of Neuroscience

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9221771%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

17

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9221771%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

15

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9221771%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

5726-5737

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9221771%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

describes a project that uses

1 reference

Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC6573204/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

Individual microtubules in the axon consist of domains that differ in both composition and stability

1 reference

https://pubmed.ncbi.nlm.nih.gov/9221771

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Stabilization of post-translational modification of microtubules during cellular morphogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/9221771

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphorylation affects the ability of tau protein to promote microtubule assembly.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9221771

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rapid changes in the distribution of GAP-43 correlate with the expression of neuronal polarity during normal development and under experimental conditions

1 reference

https://pubmed.ncbi.nlm.nih.gov/9221771

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Distinct populations of microtubules: tyrosinated and nontyrosinated alpha tubulin are distributed differently in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/9221771

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Site-specific phosphorylation of the middle molecular weight human neurofilament protein in transfected non-neuronal cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/9221771

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

NTera 2 cells: a human cell line which displays characteristics expected of a human committed neuronal progenitor cell

1 reference

https://pubmed.ncbi.nlm.nih.gov/9221771

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

p42 MAP kinase phosphorylation sites in microtubule-associated protein tau are dephosphorylated by protein phosphatase 2A1. Implications for Alzheimer's disease [corrected]

1 reference

https://pubmed.ncbi.nlm.nih.gov/9221771

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurofilament-associated protein phosphatase 2A: its possible role in preserving neurofilaments in filamentous states.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9221771

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An improved procedure for identifying and quantitating protein phosphatases in mammalian tissues

1 reference

https://pubmed.ncbi.nlm.nih.gov/9221771

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Monoclonal antibodies specific for an acetylated form of alpha-tubulin recognize the antigen in cilia and flagella from a variety of organisms

1 reference

https://pubmed.ncbi.nlm.nih.gov/9221771

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

cdc2 kinase-induced destabilization of MAP2-coated microtubules in Xenopus egg extracts

1 reference

https://pubmed.ncbi.nlm.nih.gov/9221771

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The phosphorylation state of tau in the developing rat brain is regulated by phosphoprotein phosphatases.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9221771

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The abnormal phosphorylation of tau protein at Ser-202 in Alzheimer disease recapitulates phosphorylation during development

1 reference

https://pubmed.ncbi.nlm.nih.gov/9221771

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Epitope mapping of monoclonal antibodies to the paired helical filaments of Alzheimer's disease: identification of phosphorylation sites in tau protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/9221771

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vitro effects on microtubule dynamics of purified Xenopus M phase-activated MAP kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/9221771

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Association of tau protein with microtubules in living cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/9221771

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of a novel microtubule binding and assembly domain in the developmentally regulated inter-repeat region of tau.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9221771

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The inhibition of glycogen synthase kinase-3 by insulin or insulin-like growth factor 1 in the rat skeletal muscle cell line L6 is blocked by wortmannin, but not by rapamycin: evidence that wortmannin blocks activation of the mitogen-activated prote

1 reference

https://pubmed.ncbi.nlm.nih.gov/9221771

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Epitopes that span the tau molecule are shared with paired helical filaments.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9221771

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selective stabilization of microtubules oriented toward the direction of cell migration

1 reference

https://pubmed.ncbi.nlm.nih.gov/9221771

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Abnormal tau phosphorylation at Ser396 in Alzheimer's disease recapitulates development and contributes to reduced microtubule binding

1 reference

https://pubmed.ncbi.nlm.nih.gov/9221771

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Microtubules containing acetylated alpha-tubulin in mammalian cells in culture

1 reference

https://pubmed.ncbi.nlm.nih.gov/9221771

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mapping of the Alz 50 epitope in microtubule-associated proteins tau

1 reference

https://pubmed.ncbi.nlm.nih.gov/9221771

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Light and electron microscopic studies of the distribution of microtubule-associated protein 2 in rat brain: a difference between dendritic and axonal cytoskeletons

1 reference

https://pubmed.ncbi.nlm.nih.gov/9221771

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A68: a major subunit of paired helical filaments and derivatized forms of normal Tau.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9221771

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hydrofluoric acid-treated tau PHF proteins display the same biochemical properties as normal tau

1 reference

https://pubmed.ncbi.nlm.nih.gov/9221771

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Calyculin A and okadaic acid: inhibitors of protein phosphatase activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/9221771

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differentiation of NTERA-2 clonal human embryonal carcinoma cells into neurons involves the induction of all three neurofilament proteins.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9221771

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A novel pool of protein phosphatase 2A is associated with microtubules and is regulated during the cell cycle

1 reference

https://pubmed.ncbi.nlm.nih.gov/9221771

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Proline-directed and non-proline-directed phosphorylation of PHF-tau.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9221771

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Site-specific dephosphorylation of tau protein at Ser202/Thr205 in response to microtubule depolymerization in cultured human neurons involves protein phosphatase 2A.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9221771

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Biopsy-derived adult human brain tau is phosphorylated at many of the same sites as Alzheimer's disease paired helical filament tau.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9221771

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of the phosphorylation state and microtubule-binding activity of Tau by protein phosphatase 2A.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9221771

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of microtubule-associated protein 2 by reactive astrocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/9221771

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rat monoclonal antitubulin antibodies derived by using a new nonsecreting rat cell line

1 reference

https://pubmed.ncbi.nlm.nih.gov/9221771

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regions with abundant neurofibrillary pathology in human brain exhibit a selective reduction in levels of binding-competent tau and accumulation of abnormal tau-isoforms (A68 proteins)

1 reference

https://pubmed.ncbi.nlm.nih.gov/9221771

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

10-nm filaments are induced to collapse in living cells microinjected with monoclonal and polyclonal antibodies against tubulin

1 reference

https://pubmed.ncbi.nlm.nih.gov/9221771

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Microtubule-associated protein/microtubule affinity-regulating kinase (p110mark). A novel protein kinase that regulates tau-microtubule interactions and dynamic instability by phosphorylation at the Alzheimer-specific site serine 262

1 reference

https://pubmed.ncbi.nlm.nih.gov/9221771

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Okadaic acid: a new probe for the study of cellular regulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/9221771

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Promotion of microtubule assembly in vitro by taxol

1 reference

https://pubmed.ncbi.nlm.nih.gov/9221771

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Posttranslational modification and microtubule stability

1 reference

https://pubmed.ncbi.nlm.nih.gov/9221771

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A protein factor essential for microtubule assembly

1 reference

https://pubmed.ncbi.nlm.nih.gov/9221771

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enhanced stability of microtubules enriched in detyrosinated tubulin is not a direct function of detyrosination level

1 reference

https://pubmed.ncbi.nlm.nih.gov/9221771

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A taxol-dependent procedure for the isolation of microtubules and microtubule-associated proteins (MAPs).

1 reference

https://pubmed.ncbi.nlm.nih.gov/9221771

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Microtubule dynamics in axons and dendrites

1 reference

https://pubmed.ncbi.nlm.nih.gov/9221771

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein sequence and mass spectrometric analyses of tau in the Alzheimer's disease brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/9221771

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pluripotent embryonal carcinoma clones derived from the human teratocarcinoma cell line Tera-2. Differentiation in vivo and in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/9221771

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein phosphatase inhibitors induce the selective breakdown of stable microtubules in fibroblasts and epithelial cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/9221771

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibitory effect of a marine-sponge toxin, okadaic acid, on protein phosphatases. Specificity and kinetics

1 reference

https://pubmed.ncbi.nlm.nih.gov/9221771

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Microtubules containing detyrosinated tubulin are less dynamic

1 reference

https://pubmed.ncbi.nlm.nih.gov/9221771

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Assembly and turnover of detyrosinated tubulin in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/9221771

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Monoclonal antibody PHF-1 recognizes tau protein phosphorylated at serine residues 396 and 404.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9221771

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential turnover of tyrosinated and detyrosinated microtubules

1 reference

https://pubmed.ncbi.nlm.nih.gov/9221771

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tubulin dynamics in cultured mammalian cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/9221771

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pure, postmitotic, polarized human neurons derived from NTera 2 cells provide a system for expressing exogenous proteins in terminally differentiated neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/9221771

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Distribution of tau proteins in the normal human central and peripheral nervous system

1 reference

https://pubmed.ncbi.nlm.nih.gov/9221771

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cdc2 H1 kinase is negatively regulated by a type 2A phosphatase in the Xenopus early embryonic cell cycle: evidence from the effects of okadaic acid

1 reference

https://pubmed.ncbi.nlm.nih.gov/9221771

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

p42 map kinase phosphorylation sites in microtubule-associated protein tau are dephosphorylated by protein phosphatase 2A1Implications for Alzheimer's disease

18

1 reference

10.1523/JNEUROSCI.17-15-05726.1997

https://api.crossref.org/works/10.1523/JNEUROSCI.17-15-05726.1997

6 November 2024

Identifiers

10.1523/JNEUROSCI.17-15-05726.1997

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9221771%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9221771%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9221771%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q48654126&oldid=2270954173"