(Q48305645)

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24 December 2019

title

Abeta40 inhibits amyloid deposition in vivo (English)

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24 December 2019

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24 December 2019

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24 December 2019

Luisa Onstead

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24 December 2019

Suzanne Randle

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24 December 2019

Robert Price

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24 December 2019

Lisa Smithson

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24 December 2019

Craig Zwizinski

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24 December 2019

Todd Golde

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24 December 2019

Eileen McGowan

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24 December 2019

language of work or name

English

0 references

publication date

1 January 2007

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24 December 2019

published in

Journal of Neuroscience

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24 December 2019

volume

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24 December 2019

issue

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24 December 2019

page(s)

627-633

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describes a project that uses

24 December 2019

ImageJ

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11 June 2022

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inferred from PubMed Central ID database lookup

cites work

Early phenotypic changes in transgenic mice that overexpress different mutants of amyloid precursor protein in brain

1 reference

12 December 2020

Unusual phenotypic alteration of beta amyloid precursor protein (betaAPP) maturation by a new Val-715 --> Met betaAPP-770 mutation responsible for probable early-onset Alzheimer's disease

1 reference

12 December 2020

Premature death in transgenic mice that overexpress a mutant amyloid precursor protein is preceded by severe neurodegeneration and apoptosis

1 reference

12 December 2020

Interaction between A beta(1-42) and A beta(1-40) in Alzheimer's beta-amyloid fibril formation in vitro.

1 reference

12 December 2020

High-level neuronal expression of abeta 1-42 in wild-type human amyloid protein precursor transgenic mice: synaptotoxicity without plaque formation

1 reference

12 December 2020

Inhibition of fibrillization and accumulation of prefibrillar oligomers in mixtures of human and mouse alpha-synuclein

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12 December 2020

Prominent cerebral amyloid angiopathy in transgenic mice overexpressing the london mutant of human APP in neurons.

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12 December 2020

Age-dependent changes in brain, CSF, and plasma amyloid (beta) protein in the Tg2576 transgenic mouse model of Alzheimer's disease.

1 reference

12 December 2020

Intramembrane proteolysis by presenilins

1 reference

12 December 2020

Plaque-induced abnormalities in neurite geometry in transgenic models of Alzheimer disease: implications for neural system disruption

1 reference

12 December 2020

beta-Synuclein inhibits alpha-synuclein aggregation: a possible role as an anti-parkinsonian factor

1 reference

12 December 2020

A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity

1 reference

12 December 2020

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

1 reference

12 December 2020

In vivo multiphoton imaging of a transgenic mouse model of Alzheimer disease reveals marked thioflavine-S-associated alterations in neurite trajectories

1 reference

12 December 2020

Protofibrils, pores, fibrils, and neurodegeneration: separating the responsible protein aggregates from the innocent bystanders

1 reference

12 December 2020

Hyperphosphorylation and aggregation of tau in mice expressing normal human tau isoforms

1 reference

12 December 2020

NSAIDs and enantiomers of flurbiprofen target gamma-secretase and lower Abeta 42 in vivo

1 reference

12 December 2020

Mixtures of wild-type and a pathogenic (E22G) form of Abeta40 in vitro accumulate protofibrils, including amyloid pores.

1 reference

12 December 2020

Amyloid beta-protein (Abeta)1-40 protects neurons from damage induced by Abeta1-42 in culture and in rat brain

1 reference

12 December 2020

Beta-amyloid protein oligomers induced by metal ions and acid pH are distinct from those generated by slow spontaneous ageing at neutral pH.

1 reference

12 December 2020

Amyloid-beta antibody treatment leads to rapid normalization of plaque-induced neuritic alterations.

1 reference

12 December 2020

Enhanced proteolysis of beta-amyloid in APP transgenic mice prevents plaque formation, secondary pathology, and premature death

1 reference

12 December 2020

Small assemblies of unmodified amyloid beta-protein are the proximate neurotoxin in Alzheimer's disease

1 reference

12 December 2020

A model for studying Alzheimer's Abeta42-induced toxicity in Drosophila melanogaster

1 reference

12 December 2020

Identification of loci determining susceptibility to the lethal effects of amyloid precursor protein transgene overexpression.

1 reference

12 December 2020

Therapeutic effects of PKC activators in Alzheimer's disease transgenic mice

1 reference

12 December 2020

Potential role of presenilin-regulated signaling pathways in sporadic neurodegeneration.

1 reference

12 December 2020

Abeta is targeted to the vasculature in a mouse model of hereditary cerebral hemorrhage with amyloidosis.

1 reference

12 December 2020

Nonsteroidal anti-inflammatory drugs lower Abeta42 and change presenilin 1 conformation

1 reference

12 December 2020

Fibrillar amyloid deposition leads to local synaptic abnormalities and breakage of neuronal branches.

1 reference

12 December 2020

Natural oligomers of the amyloid-beta protein specifically disrupt cognitive function

1 reference

12 December 2020

Human apolipoprotein E4 alters the amyloid-beta 40:42 ratio and promotes the formation of cerebral amyloid angiopathy in an amyloid precursor protein transgenic model.

1 reference

12 December 2020

The familial dementia BRI2 gene binds the Alzheimer gene amyloid-beta precursor protein and inhibits amyloid-beta production

1 reference

12 December 2020

BRI2 interacts with amyloid precursor protein (APP) and regulates amyloid beta (Abeta) production

1 reference

12 December 2020

The bad seed in Alzheimer's disease

1 reference

12 December 2020

Abeta42 is essential for parenchymal and vascular amyloid deposition in mice

1 reference

12 December 2020

Neuronal or glial expression of human apolipoprotein e4 affects parenchymal and vascular amyloid pathology differentially in different brain regions of double- and triple-transgenic mice

1 reference

12 December 2020

Presenilin clinical mutations can affect gamma-secretase activity by different mechanisms

1 reference

12 December 2020

Common mechanisms of amyloid oligomer pathogenesis in degenerative disease

1 reference

12 December 2020

A specific amyloid-beta protein assembly in the brain impairs memory

1 reference

12 December 2020

Deletion of presenilin 1 hydrophilic loop sequence leads to impaired gamma-secretase activity and exacerbated amyloid pathology.

1 reference

12 December 2020

Presenilin/gamma-secretase activity regulates protein clearance from the endocytic recycling compartment.

1 reference

12 December 2020

Enhanced accumulation of tau in doubly transgenic mice expressing mutant betaAPP and presenilin-1.

1 reference

12 December 2020

Mean age-of-onset of familial alzheimer disease caused by presenilin mutations correlates with both increased Abeta42 and decreased Abeta40.

1 reference

12 December 2020

1 reference

12 December 2020

Amyloid beta protein (A beta) in Alzheimer's disease brain. Biochemical and immunocytochemical analysis with antibodies specific for forms ending at A beta 40 or A beta 42(43).

1 reference

12 December 2020

Amyloid-beta aggregation: selective inhibition of aggregation in mixtures of amyloid with different chain lengths

1 reference

12 December 2020

Correlative Memory Deficits, Abeta Elevation, and Amyloid Plaques in Transgenic Mice

1 reference

12 December 2020

Diagnosis of cerebral amyloid angiopathy. Sensitivity and specificity of cortical biopsy

1 reference

12 December 2020

The role of A beta 42 in Alzheimer's disease

1 reference

12 December 2020

Alzheimer's disease: genetic studies and transgenic models

1 reference

12 December 2020

10.1523/JNEUROSCI.4849-06.2007

Identifiers

DOI

1 reference

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24 December 2019

1 reference

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24 December 2019

PubMed publication ID

17234594

1 reference

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