(Q48304802)

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Pharmacological inhibition of complement C5a-C5a1 receptor signalling ameliorates disease pathology in the hSOD1G93A mouse model of amyotrophic lateral sclerosis

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Europe PubMed Central

PMC publication ID

29 May 2018

http://europepmc.org/abstract/PMC/5368046

Pharmacological inhibition of complement C5a-C5a1 receptor signalling ameliorates disease pathology in the hSOD1G93A mouse model of amyotrophic lateral sclerosis (English)

1 reference

Europe PubMed Central

PMC publication ID

29 May 2018

http://europepmc.org/abstract/PMC/5368046

amyotrophic lateral sclerosis

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Trent M. Woodruff

6

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28128456%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

1

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Europe PubMed Central

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10 June 2020

2

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28128456%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

Marc J. Ruitenberg

4

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28128456%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

Peter G. Noakes

5

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28128456%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

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Jenny N T Fung

3

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10 June 2020

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3 March 2017

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Europe PubMed Central

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29 May 2018

http://europepmc.org/abstract/PMC/5368046

British Journal of Pharmacology

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28128456%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

174

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Europe PubMed Central

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10 June 2020

8

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Europe PubMed Central

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10 June 2020

689-699

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28128456%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

Receptor residence time trumps drug-likeness and oral bioavailability in determining efficacy of complement C5a antagonists.

1 reference

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4 June 2018

Therapeutic targeting of complement to modify disease course and improve outcomes in neurological conditions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5368046

4 June 2018

The Concise Guide to PHARMACOLOGY 2015/16: G protein-coupled receptors

1 reference

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4 June 2018

The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands

1 reference

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4 June 2018

Experimental design and analysis and their reporting: new guidance for publication in BJP.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5368046

4 June 2018

Implementing guidelines on reporting research using animals (ARRIVE etc.): new requirements for publication in BJP.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5368046

4 June 2018

The Complement Receptor C5aR Controls Acute Inflammation and Astrogliosis following Spinal Cord Injury

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5368046

4 June 2018

Role for terminal complement activation in amyotrophic lateral sclerosis disease progression.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5368046

4 June 2018

C1q induction and global complement pathway activation do not contribute to ALS toxicity in mutant SOD1 mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5368046

4 June 2018

Dysregulation of the complement cascade in the hSOD1G93A transgenic mouse model of amyotrophic lateral sclerosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5368046

4 June 2018

International Union of Basic and Clinical Pharmacology. [corrected]. LXXXVII. Complement peptide C5a, C4a, and C3a receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5368046

4 June 2018

The C5a receptor antagonist PMX205 ameliorates experimentally induced colitis associated with increased IL-4 and IL-10

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5368046

4 June 2018

Modulating inflammatory monocytes with a unique microRNA gene signature ameliorates murine ALS.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5368046

4 June 2018

Animal research: reporting in vivo experiments: the ARRIVE guidelines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5368046

4 June 2018

Activation of innate and humoral immunity in the peripheral nervous system of ALS transgenic mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5368046

4 June 2018

The role of the complement system and the activation fragment C5a in the central nervous system

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5368046

4 June 2018

Treatment with a C5aR antagonist decreases pathology and enhances behavioral performance in murine models of Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5368046

4 June 2018

CD4+ T cells support glial neuroprotection, slow disease progression, and modify glial morphology in an animal model of inherited ALS.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5368046

4 June 2018

Amyotrophic lateral sclerosis: from current developments in the laboratory to clinical implications

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5368046

4 June 2018

ALS-causing SOD1 mutants generate vascular changes prior to motor neuron degeneration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5368046

4 June 2018

Design, power, and interpretation of studies in the standard murine model of ALS

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5368046

4 June 2018

Evidence of compromised blood-spinal cord barrier in early and late symptomatic SOD1 mice modeling ALS

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5368046

4 June 2018

Ultrastructure of blood-brain barrier and blood-spinal cord barrier in SOD1 mice modeling ALS.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5368046

4 June 2018

Therapeutic activity of C5a receptor antagonists in a rat model of neurodegeneration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5368046

4 June 2018

Unraveling the mechanisms involved in motor neuron degeneration in ALS

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5368046

4 June 2018

Pharmacological characterization of antagonists of the C5a receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5368046

4 June 2018

Neutrophils promote Alzheimer's disease-like pathology and cognitive decline via LFA-1 integrin.

1 reference

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14 August 2018

Guidelines for the preclinical in vivo evaluation of pharmacological active drugs for ALS/MND: report on the 142nd ENMC international workshop.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5368046

14 August 2018

Increased potency of a novel complement factor 5a receptor antagonist in a rat model of inflammatory bowel disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5368046

14 August 2018

Potent cyclic antagonists of the complement C5a receptor on human polymorphonuclear leukocytes. Relationships between structures and activity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5368046

14 August 2018

Generation of C5a in the absence of C3: a new complement activation pathway

1 reference

https://api.crossref.org/works/10.1111%2FBPH.13730

21 January 2018

The complement factor C5a contributes to pathology in a rat model of amyotrophic lateral sclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/28128456

12 December 2020

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Identifiers

10.1111/BPH.13730

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28128456%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28128456%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28128456%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

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