(Q48214478)

9 February 2018

title

Small, highly structured RNAs participate in the conversion of human recombinant PrP(Sen) to PrP(Res) in vitro (English)

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9 February 2018

Richard Kascsak

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9 February 2018

author name string

Victor Adler

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9 February 2018

Brian Zeiler

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9 February 2018

Valentin Kryukov

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9 February 2018

Richard Rubenstein

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9 February 2018

Abraham Grossman

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9 February 2018

language of work or name

English

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publication date

1 September 2003

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9 February 2018

Journal of Molecular Biology

published in

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9 February 2018

volume

332

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9 February 2018

issue

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9 February 2018

page(s)

47-57

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9 February 2018

Novel proteinaceous infectious particles cause scrapie

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Polymerization of human prion peptide HuPrP 106-126 to amyloid in nucleic acid solution

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The prion protein has DNA strand transfer properties similar to retroviral nucleocapsid protein.

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The prion protein has RNA binding and chaperoning properties characteristic of nucleocapsid protein NCP7 of HIV-1.

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Copper converts the cellular prion protein into a protease-resistant species that is distinct from the scrapie isoform

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

Identifiers

DOI

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9 February 2018

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9 February 2018