(Q48241774)

9 February 2018

http://europepmc.org/abstract/MED/17360906

title

NMDA receptor subunits have differential roles in mediating excitotoxic neuronal death both in vitro and in vivo (English)

1 reference

9 February 2018

http://europepmc.org/abstract/MED/17360906

1 reference

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6672582&resulttype=core&format=json

16 May 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6672582&resulttype=core&format=json

16 May 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6672582&resulttype=core&format=json

16 May 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6672582&resulttype=core&format=json

16 May 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6672582&resulttype=core&format=json

16 May 2020

Yitao Liu

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6672582&resulttype=core&format=json

16 May 2020

Amanda Rooyakkers

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6672582&resulttype=core&format=json

16 May 2020

Lidong Liu

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6672582&resulttype=core&format=json

16 May 2020

Jie Lu

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6672582&resulttype=core&format=json

16 May 2020

Michael Tymianski

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6672582&resulttype=core&format=json

16 May 2020

Ann Marie Craig

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6672582&resulttype=core&format=json

16 May 2020

language of work or name

English

0 references

publication date

1 March 2007

1 reference

9 February 2018

http://europepmc.org/abstract/MED/17360906

published in

Journal of Neuroscience

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16 May 2020

volume

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16 May 2020

issue

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6672582&resulttype=core&format=json

16 May 2020

page(s)

2846-2857

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6672582&resulttype=core&format=json

The incorporation of NMDA receptors with a distinct subunit composition at nascent hippocampal synapses in vitro

16 May 2020

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Fast NMDA receptor-mediated synaptic currents in neurons from mice lacking the epsilon2 (NR2B) subunit

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Signaling events in NMDA receptor-induced apoptosis in cerebrocortical cultures

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Mitochondrial and extramitochondrial apoptotic signaling pathways in cerebrocortical neurons

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NMDA and AMPA/kainate receptors are involved in the anticonvulsant activity of riluzole in DBA/2 mice

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Activation of synaptic NMDA receptors induces membrane insertion of new AMPA receptors and LTP in cultured hippocampal neurons

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Dominant-interfering forms of MEF2 generated by caspase cleavage contribute to NMDA-induced neuronal apoptosis

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Extrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and cell death pathways

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Toward wisdom from failure: lessons from neuroprotective stroke trials and new therapeutic directions

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Dual regulation of NMDA receptor functions by direct protein-protein interactions with the dopamine D1 receptor

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Activation of PI3-kinase is required for AMPA receptor insertion during LTP of mEPSCs in cultured hippocampal neurons

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12 December 2020

Why did NMDA receptor antagonists fail clinical trials for stroke and traumatic brain injury?

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12 December 2020

Intracellular domains of NMDA receptor subtypes are determinants for long-term potentiation induction

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12 December 2020

A key role for TRPM7 channels in anoxic neuronal death

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12 December 2020

Molecular mechanisms of glutamate-dependent neurodegeneration in ischemia and traumatic brain injury

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Antiparkinsonian activity of Ro 25-6981, a NR2B subunit specific NMDA receptor antagonist, in animal models of Parkinson's disease

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12 December 2020

Neuroscience. Controlling the ups and downs of synaptic strength

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12 December 2020

Role of NMDA receptor subtypes in governing the direction of hippocampal synaptic plasticity

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12 December 2020

alpha-Amino-3-hydroxy-5-methylisoxazole-4-propionic acid subtype glutamate receptor (AMPAR) endocytosis is essential for N-methyl-D-aspartate-induced neuronal apoptosis

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12 December 2020

Differential roles of NR2A and NR2B-containing NMDA receptors in cortical long-term potentiation and long-term depression.

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12 December 2020

Neuroprotection in ischemia: blocking calcium-permeable acid-sensing ion channels.

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12 December 2020

Role of distinct NMDA receptor subtypes at central synapses

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12 December 2020

A pilot study of D-cycloserine in subjects with autistic disorder

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12 December 2020

Why do many NMDA antagonists fail, while others are safe and effective at blocking excitotoxicity associated with dementia and acute injury?

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12 December 2020

Selective subunit antagonists suggest an inhibitory relationship between NR2B and NR2A-subunit containing N-methyl-D: -aspartate receptors in hippocampal slices

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12 December 2020

Insulin exerts neuroprotection by counteracting the decrease in cell-surface GABA receptors following oxygen-glucose deprivation in cultured cortical neurons

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12 December 2020

Modulation of triheteromeric NMDA receptors by N-terminal domain ligands

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12 December 2020

Differential roles of NR2A- and NR2B-containing NMDA receptors in Ras-ERK signaling and AMPA receptor trafficking

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12 December 2020

Rap2-JNK removes synaptic AMPA receptors during depotentiation

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12 December 2020

N-methyl-D-aspartate receptor subtype mediated bidirectional control of p38 mitogen-activated protein kinase

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12 December 2020

Lack of NMDA receptor subtype selectivity for hippocampal long-term potentiation.

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12 December 2020

Activation of NR2A-containing NMDA receptors is not obligatory for NMDA receptor-dependent long-term potentiation.

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12 December 2020

Synaptic and extrasynaptic NMDA receptor NR2 subunits in cultured hippocampal neurons

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12 December 2020

Traumatic mechanical injury to the hippocampus in vitro causes regional caspase-3 and calpain activation that is influenced by NMDA receptor subunit composition.

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12 December 2020

Human immunodeficiency virus (HIV)-induced neurotoxicity: roles for the NMDA receptor subtypes.

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12 December 2020

Subunit dependencies of N-methyl-D-aspartate (NMDA) receptor-induced alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor internalization

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12 December 2020

Distinct roles for Ras-guanine nucleotide-releasing factor 1 (Ras-GRF1) and Ras-GRF2 in the induction of long-term potentiation and long-term depression.

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12 December 2020

Developmental changes in NMDA neurotoxicity reflect developmental changes in subunit composition of NMDA receptors.

1 reference

12 December 2020

Activation kinetics reveal the number of glutamate and glycine binding sites on the N-methyl-d-aspartate receptor

1 reference

12 December 2020

Block of N-methyl-D-aspartate-activated current by the anticonvulsant MK-801: selective binding to open channels

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12 December 2020

Reversible middle cerebral artery occlusion without craniectomy in rats

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12 December 2020

Photochemical stroke model: flunarizine prevents sensorimotor deficits after neocortical infarcts in rats

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12 December 2020

Rat middle cerebral artery occlusion: evaluation of the model and development of a neurologic examination

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12 December 2020

Elevation of the Extracellular Concentrations of Glutamate and Aspartate in Rat Hippocampus During Transient Cerebral Ischemia Monitored by Intracerebral Microdialysis

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12 December 2020

Delayed treatment with AMPA, but not NMDA, antagonists reduces neocortical infarction

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12 December 2020

Developmental and regional expression in the rat brain and functional properties of four NMDA receptors

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12 December 2020

Apoptosis and necrosis: two distinct events induced, respectively, by mild and intense insults with N-methyl-D-aspartate or nitric oxide/superoxide in cortical cell cultures

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12 December 2020

Reduced hippocampal LTP and spatial learning in mice lacking NMDA receptor epsilon 1 subunit

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12 December 2020

Calcium and excitotoxic neuronal injury.

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12 December 2020

Excitatory amino acids as a final common pathway for neurologic disorders.

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12 December 2020

Kinetics of AP5 dissociation from NMDA receptors: evidence for two identical cooperative binding sites

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12 December 2020

N-methyl-D-aspartic acid receptor structure and function

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12 December 2020

Combined oxygen and glucose deprivation in cortical cell culture: calcium-dependent and calcium-independent mechanisms of neuronal injury

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12 December 2020

Short therapeutic window for MK-801 in transient focal cerebral ischemia in normotensive rats

1 reference

12 December 2020

Impairment of suckling response, trigeminal neuronal pattern formation, and hippocampal LTD in NMDA receptor epsilon 2 subunit mutant mice

1 reference

12 December 2020

Regulation of neuronal survival by the serine-threonine protein kinase Akt

1 reference

12 December 2020

Neuroprotective signal transduction: relevance to stroke

1 reference

12 December 2020

Ro 25-6981, a highly potent and selective blocker of N-methyl-D-aspartate receptors containing the NR2B subunit. Characterization in vitro

1 reference

12 December 2020

Increased contribution of NR2A subunit to synaptic NMDA receptors in developing rat cortical neurons

1 reference

12 December 2020

The problem of assessing effective neuroprotection in experimental cerebral ischemia

1 reference

12 December 2020

In vitro binding properties in rat brain of [3H]Ro 25-6981, a potent and selective antagonist of NMDA receptors containing NR2B subunits

1 reference

12 December 2020

Calcium, free radicals and excitotoxins in neuronal apoptosis.

1 reference

12 December 2020

Protein kinase B (c-Akt): a multifunctional mediator of phosphatidylinositol 3-kinase activation.

1 reference

12 December 2020

Blockade of NMDA receptors and apoptotic neurodegeneration in the developing brain

1 reference

12 December 2020

10.1523/JNEUROSCI.0116-07.2007

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6672582&resulttype=core&format=json

16 May 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6672582&resulttype=core&format=json

16 May 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6672582&resulttype=core&format=json