(Q48037869)

7 February 2018

review article

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title

Somatic hypermutation in normal and transformed human B cells (English)

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7 February 2018

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7 February 2018

Ralf Küppers

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7 February 2018

author name string

Klein U

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7 February 2018

Goossens T

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7 February 2018

Fischer M

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7 February 2018

Kanzler H

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7 February 2018

Braeuninger A

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7 February 2018

publication date

1 April 1998

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7 February 2018

published in

Immunological Reviews

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7 February 2018

volume

162

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7 February 2018

page(s)

261-280

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7 February 2018

Clonal selection and learning in the antibody system

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Maturation of the immune response in germinal centers

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Analysis of somatic mutation in five B cell subsets of human tonsil

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Variable region gene analysis of B cell subsets derived from a 4-year-old child: somatically mutated memory B cells accumulate in the peripheral blood already at young age.

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Human splenic IgM immunoglobulin transcripts are mutated at high frequency

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Germinal centres in T-cell-dependent antibody responses

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Memory B lymphocytes migrate to bone marrow in humans

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Detection of minimal disease using rearranged immunoglobulin heavy chain genes from intermediate- and high-grade malignant B cell non-Hodgkin’s lymphoma

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Clustering of extensive somatic mutations in the variable region of an immunoglobulin heavy chain gene from a human B cell lymphoma

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Extensive and selective mutation of a rearranged VH5 gene in human B cell chronic lymphocytic leukemia

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Somatic diversification and selection of immunoglobulin heavy and light chain variable region genes in IgG+ CD5+ chronic lymphocytic leukemia B cells

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Lack of extensive mutations in the VH5 genes used in common B cell chronic lymphocytic leukemia

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The pathogenesis of chronic lymphocytic leukemia: analysis of the antibody repertoire

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Hodgkin's disease with monoclonal and polyclonal populations of Reed-Sternberg cells

21 January 2018

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Hodgkin and Reed-Sternberg cells in Hodgkin's disease represent the outgrowth of a dominant tumor clone derived from (crippled) germinal center B cells.

21 January 2018

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Hodgkin and Reed-Sternberg cells in lymphocyte predominant Hodgkin disease represent clonal populations of germinal center-derived tumor B cells

21 January 2018

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Origin of Nodular Lymphocyte-Predominant Hodgkin's Disease from a Clonal Expansion of Highly Mutated Germinal-Center B Cells

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Discriminating intrinsic and antigen-selected mutational hotspots in immunoglobulin V genes

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21 January 2018

Somatic hypermutation

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Somatic hypermutation of immunoglobulin genes

21 January 2018

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Somatic hypermutagenesis in immunoglobulin genes. II. Influence of neighbouring base sequences on mutagenesis

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Cells strongly expressing Ig(kappa) transgenes show clonal recruitment of hypermutation: a role for both MAR and the enhancers.

21 January 2018

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The kappa-deleting element. Germline and rearranged, duplicated and dispersed forms

21 January 2018

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A uniform deleting element mediates the loss of kappa genes in human B cells

21 January 2018

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Variable region sequences of murine IgM anti-IgG monoclonal autoantibodies (rheumatoid factors). A structural explanation for the high frequency of IgM anti-IgG B cells

21 January 2018

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The CDR1 sequences of a major proportion of human germline Ig VH genes are inherently susceptible to amino acid replacement

21 January 2018

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Frequent occurrence of deletions and duplications during somatic hypermutation: implications for oncogene translocations and heavy chain disease

21 January 2018

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Zonal distribution of immunoglobulin-synthesizing cells within the germinal centre: an in situ hybridization and immunohistochemical study

21 January 2018

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Antigen-induced B-cell death and elimination during germinal-centre immune responses

21 January 2018

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Soluble antigen can cause enhanced apoptosis of germinal-centre B cells.

21 January 2018

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Molecular characterization of human antibodies to bacterial antigens: utilization of the less frequently expressed VH2 and VH6 heavy chain variable region gene families

21 January 2018

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V(D)J Recombination in Mature B Cells: A Mechanism for Altering Antibody Responses

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1600-065X.1998.TB01447.X

Hypothesis: somatic hypermutation by gene conversion via the error prone DNA----RNA----DNA information loop

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1600-065X.1998.TB01447.X

The t(8; 14) chromosomal translocation occurring in B-cell malignancies results from mistakes in V-D-J joining

21 January 2018

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Generation of a variant t(2;8) translocation of Burkitt's lymphoma by site-specific recombination via the kappa light-chain joining signals

21 January 2018

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Multistep evolution of B-cell-derived tumors in humans and rodents

21 January 2018

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Three breakpoints of variant t(2;8) translocations in Burkitt's lymphoma cells fall within a region 140 kilobases distal from c-myc

21 January 2018

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Genetic recombination in a chromosomal translocation t(2;8)(p11;q24) of a Burkitt's lymphoma cell line, KOBK101.

21 January 2018

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BCL8, a novel gene involved in translocations affecting band 15q11-13 in diffuse large-cell lymphoma

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1600-065X.1998.TB01447.X

Analysis of mutations in immunoglobulin heavy chain variable region genes of microdissected marginal zone (MGZ) B cells suggests that the MGZ of human spleen is a reservoir of memory B cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.1998.TB01447.X

Memory B cells from human tonsils colonize mucosal epithelium and directly present antigen to T cells by rapid up-regulation of B7-1 and B7-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.1998.TB01447.X

Clonal expansion in follicular lymphoma occurs subsequent to antigenic selection

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1600-065X.1998.TB01447.X

Phenotype, genotype and clonality of Reed-Sternberg cells in nodular sclerosis Hodgkin's disease: results of a single-cell study

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.1998.TB01447.X

10.1111/J.1600-065X.1998.TB01447.X

21 January 2018

Identifiers

DOI

1 reference

7 February 2018

1 reference

7 February 2018