(Q47930930)

6 February 2018

title

Alpha-synuclein has a high affinity for packing defects in a bilayer membrane: a thermodynamics study (English)

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6 February 2018

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Christian Haass

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author name string

Brigitte Nuscher

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6 February 2018

Frits Kamp

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6 February 2018

Thomas Mehnert

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6 February 2018

Sabine Odoy

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6 February 2018

Philipp J Kahle

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6 February 2018

Klaus Beyer

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6 February 2018

language of work or name

English

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publication date

17 March 2004

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6 February 2018

Journal of Biological Chemistry

number of pages

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based on heuristic

inferred from page(s)

published in

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6 February 2018

volume

279

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6 February 2018

issue

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6 February 2018

page(s)

21966-21975

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6 February 2018

Alpha-synuclein and neurodegenerative diseases

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alpha-Synuclein locus triplication causes Parkinson's disease

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Fiber diffraction of synthetic alpha-synuclein filaments shows amyloid-like cross-beta conformation

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Parkinson's disease-associated alpha-synuclein is more fibrillogenic than beta- and gamma-synuclein and cannot cross-seed its homologs

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Biophysical properties of the synucleins and their propensities to fibrillate: inhibition of alpha-synuclein assembly by beta- and gamma-synucleins

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Structural organization of alpha-synuclein fibrils studied by site-directed spin labeling

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NACP, a protein implicated in Alzheimer's disease and learning, is natively unfolded

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Conformational properties of alpha-synuclein in its free and lipid-associated states

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Stabilization of alpha-synuclein secondary structure upon binding to synthetic membranes

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Interaction of human alpha-Synuclein and Parkinson's disease variants with phospholipids. Structural analysis using site-directed mutagenesis.

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A broken alpha -helix in folded alpha -Synuclein

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Lipid binding inhibits alpha-synuclein fibril formation

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Exposure to long chain polyunsaturated fatty acids triggers rapid multimerization of synucleins.

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Lipid droplet binding and oligomerization properties of the Parkinson's disease protein alpha-synuclein

21 January 2018

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The formation of highly soluble oligomers of alpha-synuclein is regulated by fatty acids and enhanced in Parkinson's disease

21 January 2018

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Rapid Anionic Micelle-mediated α-Synuclein Fibrillization in Vitro

21 January 2018

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21 January 2018

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Selective insolubility of alpha-synuclein in human Lewy body diseases is recapitulated in a transgenic mouse model

21 January 2018

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21 January 2018

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21 January 2018

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The association of alpha-synuclein with membranes affects bilayer structure, stability, and fibril formation

21 January 2018

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Direct measurement of protein binding energetics by isothermal titration calorimetry

21 January 2018

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Interaction of a mitochondrial presequence with lipid membranes: role of helix formation for membrane binding and perturbation

21 January 2018

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Thermodynamics of the coil-alpha-helix transition of amphipathic peptides in a membrane environment: the role of vesicle curvature

21 January 2018

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α-Synuclein Association with Phosphatidylglycerol Probed by Lipid Spin Labels

21 January 2018

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A structural and functional role for 11-mer repeats in alpha-synuclein and other exchangeable lipid binding proteins

21 January 2018

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Synaptic vesicle size and number are regulated by a clathrin adaptor protein required for endocytosis

21 January 2018

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Asymmetry of lipid organization in cholinergic synaptic vesicle membranes

21 January 2018

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Sphingomyelin: biophysical aspects

21 January 2018

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A calorimetric and fluorescent probe study of the gel-liquid crystalline phase transition in small, single-lamellar dipalmitoylphosphatidylcholine vesicles

21 January 2018

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Phase transitions in phospholipid model membranes of different curvature

21 January 2018

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The enthalpy of the alanine peptide helix measured by isothermal titration calorimetry using metal-binding to induce helix formation

21 January 2018

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The mechanism of alpha-helix formation by peptides

21 January 2018

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Critical effects from lipid-protein interaction in membranes. I. Theoretical description

21 January 2018

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Interaction of the sperm adhesive protein, bindin, with phospholipid vesicles. I. Specific association of bindin with gel-phase phospholipid vesicles

21 January 2018

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Analysis of the membrane-interacting domain of the sea urchin sperm adhesive protein bindin

21 January 2018

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Interaction between the 35 kDa apolipoprotein of pulmonary surfactant and saturated phosphatidylcholines. Effects of temperature

21 January 2018

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Distribution of lipids in subcellular particles of guinea-pig brain

21 January 2018

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The preparation and characterization of synaptic vesicles of high purity

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.M401076200

1 reference

6 February 2018

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6 February 2018