(Q46878044)

26 December 2017

title

Activation of PAK by HIV and SIV Nef: importance for AIDS in rhesus macaques (English)

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26 December 2017

author name string

Sawai ET

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26 December 2017

Khan IH

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26 December 2017

Montbriand PM

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26 December 2017

Peterlin BM

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26 December 2017

Cheng-Mayer C

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26 December 2017

Luciw PA

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26 December 2017

language of work or name

English

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publication date

1 November 1996

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26 December 2017

published in

Current Biology

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26 December 2017

volume

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26 December 2017

issue

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26 December 2017

page(s)

1519-1527

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26 December 2017

The role of Nef in the replication cycle of the human and simian immunodeficiency viruses

cites work

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Importance of the nef gene for maintenance of high virus loads and for development of AIDS

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7 January 2021

HIV-1 Nef leads to inhibition or activation of T cells depending on its intracellular localization

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Altered T cell activation and development in transgenic mice expressing the HIV-1 nef gene

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Identification of a nef allele that causes lymphocyte activation and acute disease in Macaque monkeys

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7 January 2021

Nef induces CD4 endocytosis: requirement for a critical dileucine motif in the membrane-proximal CD4 cytoplasmic domain

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7 January 2021

Specific suppression of human CD4 surface expression by Nef from the pathogenic simian immunodeficiency virus SIVmac239open

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7 January 2021

Serine phosphorylation-independent downregulation of cell-surface CD4 by nef

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7 January 2021

Optimal infectivity in vitro of human immunodeficiency virus type 1 requires an intact nef gene.

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7 January 2021

The human immunodeficiency virus-1 nef gene product: a positive factor for viral infection and replication in primary lymphocytes and macrophages

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7 January 2021

Expression of the human immunodeficiency virus type 1 (HIV-1) nef gene during HIV-1 production increases progeny particle infectivity independently of gp160 or viral entry.

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Myristoylation-dependent binding of HIV-1 Nef to CD4.

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7 January 2021

Physical and functional interaction of Nef with Lck. HIV-1 Nef-induced T-cell signaling defects.

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7 January 2021

A single amino acid in the SH3 domain of Hck determines its high affinity and specificity in binding to HIV-1 Nef protein

1 reference

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7 January 2021

Proline-rich (PxxP) motifs in HIV-1 Nef bind to SH3 domains of a subset of Src kinases and are required for the enhanced growth of Nef+ viruses but not for down-regulation of CD4

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7 January 2021

Human immunodeficiency virus type 1 Nef associates with a cellular serine kinase in T lymphocytes

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7 January 2021

A conserved domain and membrane targeting of Nef from HIV and SIV are required for association with a cellular serine kinase activity

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7 January 2021

A brain serine/threonine protein kinase activated by Cdc42 and Rac1

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7 January 2021

Cdc42 and PAK-mediated signaling leads to Jun kinase and p38 mitogen-activated protein kinase activation

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7 January 2021

Identification of a mouse p21Cdc42/Rac activated kinase

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7 January 2021

Human Ste20 homologue hPAK1 links GTPases to the JNK MAP kinase pathway

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7 January 2021

Rho Family GTPases Regulate p38 Mitogen-activated Protein Kinase through the Downstream Mediator Pak1

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7 January 2021

Regulation of human leukocyte p21-activated kinases through G protein--coupled receptors

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7 January 2021

A novel serine/threonine kinase binding the Ras-related RhoA GTPase which translocates the kinase to peripheral membranes

1 reference

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7 January 2021

Activation of the SAPK pathway by the human STE20 homologue germinal centre kinase

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7 January 2021

A conserved binding motif defines numerous candidate target proteins for both Cdc42 and Rac GTPases

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7 January 2021

Induction of AIDS in rhesus monkeys by molecularly cloned simian immunodeficiency virus

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7 January 2021

Phosphorylation-dependent human immunodeficiency virus type 1 infection and nuclear targeting of viral DNA

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7 January 2021

HIV-1 infection of nondividing cells: C-terminal tyrosine phosphorylation of the viral matrix protein is a key regulator

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7 January 2021

HIV nuclear import is governed by the phosphotyrosine-mediated binding of matrix to the core domain of integrase

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7 January 2021

New concepts in the immunopathogenesis of HIV infection

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7 January 2021

Genomic structure of an attenuated quasi species of HIV-1 from a blood transfusion donor and recipients

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7 January 2021

Brief report: absence of intact nef sequences in a long-term survivor with nonprogressive HIV-1 infection

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2896%2900757-9

7 January 2021

Crystal structure of the conserved core of HIV-1 Nef complexed with a Src family SH3 domain

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2896%2900757-9

7 January 2021

Persistent infection of rhesus macaques with T-cell-line-tropic and macrophage-tropic clones of simian/human immunodeficiency viruses (SHIV)

1 reference

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7 January 2021

Viral determinants of simian immunodeficiency virus (SIV) virulence in rhesus macaques assessed by using attenuated and pathogenic molecular clones of SIVmac

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7 January 2021

10.1016/S0960-9822(96)00757-9

Identifiers

DOI

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26 December 2017

1 reference

26 December 2017