(Q46862539)

25 December 2017

title

Akt mediates mitochondrial protection in cardiomyocytes through phosphorylation of mitochondrial hexokinase-II. (English)

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25 December 2017

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25 December 2017

author name string

Miyamoto S

series ordinal

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25 December 2017

Brown JH

series ordinal

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25 December 2017

publication date

7 December 2007

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25 December 2017

Cell Death & Differentiation

published in

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25 December 2017

volume

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25 December 2017

issue

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25 December 2017

page(s)

521-529

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25 December 2017

Cardiomyocyte apoptosis induced by Galphaq signaling is mediated by permeability transition pore formation and activation of the mitochondrial death pathway.

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Akt promotes survival of cardiomyocytes in vitro and protects against ischemia-reperfusion injury in mouse heart.

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Akt activation preserves cardiac function and prevents injury after transient cardiac ischemia in vivo

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Ca2+ dysregulation induces mitochondrial depolarization and apoptosis: role of Na+/Ca2+ exchanger and AKT.

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Cardiotrophin 1 (CT-1) inhibition of cardiac myocyte apoptosis via a mitogen-activated protein kinase-dependent pathway. Divergence from downstream CT-1 signals for myocardial cell hypertrophy

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The cytoprotective effects of the glycoprotein 130 receptor-coupled cytokine, cardiotrophin-1, require activation of NF-kappa B.

21 January 2018

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Sphingosine 1-phosphate S1P2 and S1P3 receptor-mediated Akt activation protects against in vivo myocardial ischemia-reperfusion injury

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Nuclear targeting of Akt enhances kinase activity and survival of cardiomyocytes

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Myocardial protection by insulin at reperfusion requires early administration and is mediated via Akt and p70s6 kinase cell-survival signaling

21 January 2018

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Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt

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Mechanisms of apoptosis in the heart

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The mitochondrial death pathway and cardiac myocyte apoptosis

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Regulation of cell death: the calcium-apoptosis link

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The pathophysiology of mitochondrial cell death

21 January 2018

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The ADP/ATP translocator is not essential for the mitochondrial permeability transition pore

21 January 2018

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Cyclophilin D-dependent mitochondrial permeability transition regulates some necrotic but not apoptotic cell death

21 January 2018

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Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death

21 January 2018

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Voltage-dependent anion channels are dispensable for mitochondrial-dependent cell death

21 January 2018

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In self-defence: hexokinase promotes voltage-dependent anion channel closure and prevents mitochondria-mediated apoptotic cell death

21 January 2018

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Mitochondrial binding of hexokinase II inhibits Bax-induced cytochrome c release and apoptosis.

21 January 2018

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Hexokinase II: the integration of energy metabolism and control of apoptosis

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Akt inhibits apoptosis downstream of BID cleavage via a glucose-dependent mechanism involving mitochondrial hexokinases

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Suppression of apoptosis by cyclophilin D via stabilization of hexokinase II mitochondrial binding in cancer cells.

21 January 2018

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Hexokinase-mitochondria interaction mediated by Akt is required to inhibit apoptosis in the presence or absence of Bax and Bak

21 January 2018

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Mechanistically distinct steps in the mitochondrial death pathway triggered by oxidative stress in cardiac myocytes

21 January 2018

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Akt/protein kinase B signaling inhibitor-2, a selective small molecule inhibitor of Akt signaling with antitumor activity in cancer cells overexpressing Akt.

21 January 2018

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Increased phosphorylation of Akt substrate of 160 kDa (AS160) in rat skeletal muscle in response to insulin or contractile activity

21 January 2018

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Mitochondrial hexokinase in brain of various species: differences in sensitivity to solubilization by glucose 6-phosphate

21 January 2018

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An inverse relation between mitochondrial hexokinase content and phosphoglucomutase activity of rat tissues

21 January 2018

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Spatio-temporal dynamics of protein kinase B/Akt signaling revealed by a genetically encoded fluorescent reporter

21 January 2018

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Ischemic preconditioning, insulin, and morphine all cause hexokinase redistribution

21 January 2018

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Increased hexokinase activity, of either ectopic or endogenous origin, protects renal epithelial cells against acute oxidant-induced cell death

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4402285

Elevated expression of hexokinase II protects human lung epithelial-like A549 cells against oxidative injury

21 January 2018

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Xestospongin C, a selective and membrane-permeable inhibitor of IP(3) receptor, attenuates the positive inotropic effect of alpha-adrenergic stimulation in guinea-pig papillary muscle

21 January 2018

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RhoA/Rho kinase up-regulate Bax to activate a mitochondrial death pathway and induce cardiomyocyte apoptosis

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4402285

Adenoviral gene transfer of activated phosphatidylinositol 3'-kinase and Akt inhibits apoptosis of hypoxic cardiomyocytes in vitro

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4402285

7 January 2021

Activation of glycogen synthase kinase 3beta disrupts the binding of hexokinase II to mitochondria by phosphorylating voltage-dependent anion channel and potentiates chemotherapy-induced cytotoxicity

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4402285

7 January 2021

Rapid accumulation of Akt in mitochondria following phosphatidylinositol 3-kinase activation

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4402285

7 January 2021

VDAC1 serves as a mitochondrial binding site for hexokinase in oxidative muscles

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4402285

7 January 2021

Identifiers

DOI

10.1038/SJ.CDD.4402285

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25 December 2017

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25 December 2017