(Q46593630)

23 December 2017

title

Fen1 mutations result in autoimmunity, chronic inflammation and cancers (English)

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23 December 2017

author name string

Li Zheng

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23 December 2017

Huifang Dai

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23 December 2017

Mian Zhou

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23 December 2017

Mei Li

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23 December 2017

Purnima Singh

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23 December 2017

Junzhuan Qiu

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23 December 2017

Walter Tsark

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23 December 2017

Qin Huang

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23 December 2017

Kemp Kernstine

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23 December 2017

Xuemei Zhang

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23 December 2017

Dongxin Lin

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23 December 2017

Binghui Shen

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23 December 2017

language of work or name

English

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publication date

24 June 2007

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23 December 2017

published in

Nature Medicine

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23 December 2017

volume

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23 December 2017

issue

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23 December 2017

page(s)

812-819

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23 December 2017

Soluble tumor necrosis factor (TNF) receptors conserve TNF bioactivity in meningitis patient spinal fluid

cites work

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Tumor-associated macrophages express lymphatic endothelial growth factors and are related to peritumoral lymphangiogenesis

21 January 2018

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The FEN-1 family of structure-specific nucleases in eukaryotic DNA replication, recombination and repair

21 January 2018

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7 January 2021

Flap endonuclease 1: a central component of DNA metabolism

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7 January 2021

Multiple but dissectible functions of FEN-1 nucleases in nucleic acid processing, genome stability and diseases.

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7 January 2021

The characterization of a mammalian DNA structure-specific endonuclease

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7 January 2021

Haploinsufficiency of Flap endonuclease (Fen1) leads to rapid tumor progression

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7 January 2021

Fen-1 facilitates homologous recombination by removing divergent sequences at DNA break ends

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7 January 2021

CRN-1, a Caenorhabditis elegans FEN-1 homologue, cooperates with CPS-6/EndoG to promote apoptotic DNA degradation

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7 January 2021

Novel function of the flap endonuclease 1 complex in processing stalled DNA replication forks

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Requirement of the yeast RTH1 5' to 3' exonuclease for the stability of simple repetitive DNA.

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7 January 2021

Characterization of a mutant strain of Saccharomyces cerevisiae with a deletion of the RAD27 gene, a structural homolog of the RAD2 nucleotide excision repair gene

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7 January 2021

A novel mutation avoidance mechanism dependent on S. cerevisiae RAD27 is distinct from DNA mismatch repair

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7 January 2021

Flap endonuclease 1: a novel tumour suppresser protein

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7 January 2021

Multiple mutations and cancer

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7 January 2021

Cancer as an evolutionary and ecological process

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7 January 2021

A census of human cancer genes

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7 January 2021

A blast from the past: clearance of apoptotic cells regulates immune responses.

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7 January 2021

Pathogenesis of the glomerulonephritis of NZB/W mice

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7 January 2021

Activation of natural killer T cells in NZB/W mice induces Th1-type immune responses exacerbating lupus

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7 January 2021

Complement amplification revisited

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7 January 2021

Features of systemic lupus erythematosus in Dnase1-deficient mice

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7 January 2021

Human cancers express a mutator phenotype

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7 January 2021

APC mutations are infrequent but present in human lung cancer

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7 January 2021

EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy

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7 January 2021

K-ras oncogene activation as a prognostic marker in adenocarcinoma of the lung

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7 January 2021

Assessing TP53 status in human tumours to evaluate clinical outcome

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7 January 2021

Molecular Pathogenesis of Lung Cancer

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7 January 2021

Mutation in Rpa1 results in defective DNA double-strand break repair, chromosomal instability and cancer in mice

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7 January 2021

Surfing the p53 network

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7 January 2021

Inflammation and cancer

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7 January 2021

The epigenetic progenitor origin of human cancer

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7 January 2021

Regulation of the human apoptotic DNase/RNase endonuclease G: involvement of Hsp70 and ATP

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7 January 2021

Chromatin-IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors

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7 January 2021

A Toll-like receptor-independent antiviral response induced by double-stranded B-form DNA.

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7 January 2021

Toll-like receptor-independent gene induction program activated by mammalian DNA escaped from apoptotic DNA degradation

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7 January 2021

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7 January 2021

IL-12 Acts Directly on DC to Promote Nuclear Localization of NF-κB and Primes DC for IL-12 Production

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7 January 2021

Requirement for NF-(kappa)B in interleukin-4-induced androgen receptor activation in prostate cancer cells.

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7 January 2021

Thrombopoietin stimulates migration and activates multiple signaling pathways in hepatoblastoma cells.

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7 January 2021

Chemokines--chemotactic cytokines that mediate inflammation

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7 January 2021

Activators and target genes of Rel/NF-kappaB transcription factors

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7 January 2021

IKKbeta links inflammation and tumorigenesis in a mouse model of colitis-associated cancer

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7 January 2021

NF-kappaB functions as a tumour promoter in inflammation-associated cancer

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7 January 2021

Disruption of the FEN-1/PCNA interaction results in DNA replication defects, pulmonary hypoplasia, pancytopenia, and newborn lethality in mice

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7 January 2021

Replacement of chromosome segments with altered DNA sequences constructed in vitro

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7 January 2021

Requirement of mammalian DNA polymerase-beta in base-excision repair.

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7 January 2021

Detection of nucleosome-IgG immune complexes in ascites from mice transplanted with anti-DNA antibody-secreting hybridomas and in plasma from MRL-lpr/lpr mice

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7 January 2021

Impaired pulmonary NF-kappaB activation in response to lipopolysaccharide in NADPH oxidase-deficient mice

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7 January 2021

Identifiers

DOI

10.1038/NM1599

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23 December 2017

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23 December 2017