(Q46487763)

22 December 2017

title

Engineering conformational destabilization into mouse apolipoprotein E. A model for a unique property of human apolipoprotein E4. (English)

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22 December 2017

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22 December 2017

author name string

Clare A Peters-Libeu

series ordinal

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22 December 2017

Karl H Weisgraber

series ordinal

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22 December 2017

language of work or name

English

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publication date

11 May 2005

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22 December 2017

Journal of Biological Chemistry

published in

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22 December 2017

volume

280

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22 December 2017

issue

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22 December 2017

page(s)

26477-26482

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22 December 2017

Apolipoprotein E associated with astrocytic glia of the central nervous system and with nonmyelinating glia of the peripheral nervous system

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Association of apolipoprotein E polymorphism with outcome after head injury.

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Apolipoprotein E genotype related differences in brain lesions of multiple sclerosis

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Human apolipoprotein E4 domain interaction. Arginine 61 and glutamic acid 255 interact to direct the preference for very low density lipoproteins

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Apolipoprotein E4 domain interaction occurs in living neuronal cells as determined by fluorescence resonance energy transfer

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Differences in stability among the human apolipoprotein E isoforms determined by the amino-terminal domain

21 January 2018

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Apolipoprotein E4 forms a molten globule. A potential basis for its association with disease.

21 January 2018

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Comparison of the stabilities and unfolding pathways of human apolipoprotein E isoforms by differential scanning calorimetry and circular dichroism.

21 January 2018

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Lipid binding ability of human apolipoprotein E N-terminal domain isoforms: correlation with protein stability?

21 January 2018

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Introduction of human apolipoprotein E4 "domain interaction" into mouse apolipoprotein E

21 January 2018

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Functional characterization of apolipoprotein E isoforms overexpressed in Escherichia coli

21 January 2018

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Automated MAD and MIR structure solution

21 January 2018

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Refinement of macromolecular structures by the maximum-likelihood method

21 January 2018

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Determination and analysis of urea and guanidine hydrochloride denaturation curves

21 January 2018

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Three-dimensional structure of the LDL receptor-binding domain of human apolipoprotein E

21 January 2018

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Conformational flexibility in the apolipoprotein E amino-terminal domain structure determined from three new crystal forms: Implications for lipid binding

21 January 2018

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Kinetics of lipid-protein interactions: interaction of apolipoprotein A-I from human plasma high density lipoproteins with phosphatidylcholines

21 January 2018

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Effects of polymorphism on the lipid interaction of human apolipoprotein E.

21 January 2018

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Instability, unfolding and aggregation of human lysozyme variants underlying amyloid fibrillogenesis

21 January 2018

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Protein subunit interactions and structural integrity of amyloidogenic transthyretins: evidence from electrospray mass spectrometry

21 January 2018

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Amyloid fibrils from muscle myoglobin

21 January 2018

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Apolipoprotein E immunoreactivity in cerebral amyloid deposits and neurofibrillary tangles in Alzheimer's disease and kuru plaque amyloid in Creutzfeldt-Jakob disease

21 January 2018

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Is Alzheimer's disease an apolipoprotein E amyloidosis?

21 January 2018

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Apolipoprotein E associates with beta amyloid peptide of Alzheimer's disease to form novel monofibrils. Isoform apoE4 associates more efficiently than apoE3

21 January 2018

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Increased amyloid beta-peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late-onset Alzheimer disease

21 January 2018

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Lack of apolipoprotein E dramatically reduces amyloid β-peptide deposition

21 January 2018

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Expression of human apolipoprotein E reduces amyloid-beta deposition in a mouse model of Alzheimer's disease

21 January 2018

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Apolipoprotein E isoform-dependent amyloid deposition and neuritic degeneration in a mouse model of Alzheimer's disease

21 January 2018

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Role of apoE/Abeta interactions in Alzheimer's disease: insights from transgenic mouse models

21 January 2018

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A nontransgenic mouse model shows inducible amyloid-beta (Abeta) peptide deposition and elucidates the role of apolipoprotein E in the amyloid cascade

21 January 2018

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Apolipoprotein E4 potentiates amyloid beta peptide-induced lysosomal leakage and apoptosis in neuronal cells

21 January 2018

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Amyloid-associated proteins α1-antichymotrypsin and apolipoprotein E promote assembly of Alzheimer β-protein into filaments

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.M503910200

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22 December 2017

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22 December 2017