(Q46458312)

22 December 2017

title

Positive regulation of A-RAF by phosphorylation of isoform-specific hinge segment and identification of novel phosphorylation sites (English)

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22 December 2017

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22 December 2017

author name string

Angela Baljuls

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22 December 2017

Werner Schmitz

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22 December 2017

Thomas Mueller

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22 December 2017

Albert Sickmann

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22 December 2017

Mirko Hekman

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22 December 2017

Ulf R Rapp

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22 December 2017

language of work or name

English

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publication date

28 July 2008

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22 December 2017

Journal of Biological Chemistry

published in

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22 December 2017

volume

283

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22 December 2017

issue

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22 December 2017

page(s)

27239-27254

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22 December 2017

Structure and biological activity of v-raf, a unique oncogene transduced by a retrovirus

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21 January 2018

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Dynamic changes in C-Raf phosphorylation and 14-3-3 protein binding in response to growth factor stimulation: differential roles of 14-3-3 protein binding sites

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B- and C-RAF display essential differences in their binding to Ras: the isotype-specific N terminus of B-RAF facilitates Ras binding

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Regulation of Raf by Akt controls growth and differentiation in vascular smooth muscle cells

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Cyclic AMP blocks cell growth through Raf-1-dependent and Raf-1-independent mechanisms

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Identification of Raf-1 S471 as a novel phosphorylation site critical for Raf-1 and B-Raf kinase activities and for MEK binding

21 January 2018

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Activation of B-Raf kinase requires phosphorylation of the conserved residues Thr598 and Ser601.

21 January 2018

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Positive and negative regulation of Raf kinase activity and function by phosphorylation

21 January 2018

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95-kilodalton B-Raf serine/threonine kinase: identification of the protein and its major autophosphorylation site

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21 January 2018

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Novel C-Raf phosphorylation sites: serine 296 and 301 participate in Raf regulation

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Identification of novel in vivo Raf-1 phosphorylation sites mediating positive feedback Raf-1 regulation by extracellular signal-regulated kinase

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21 January 2018

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Phosphorylation of Raf-1 Serine 338-Serine 339 Is an Essential Regulatory Event for Ras-Dependent Activation and Biological Signaling

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21 January 2018

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Serine and tyrosine phosphorylations cooperate in Raf-1, but not B-Raf activation

21 January 2018

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Unique N-region determines low basal activity and limited inducibility of A-RAF kinase: the role of N-region in the evolutionary divergence of RAF kinase function in vertebrates

21 January 2018

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Functional analysis of the regulatory requirements of B-Raf and the B-Raf(V600E) oncoprotein

21 January 2018

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21 January 2018

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Electrostatics of nanosystems: application to microtubules and the ribosome

21 January 2018

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AMBER force-field parameters for phosphorylated amino acids in different protonation states: phosphoserine, phosphothreonine, phosphotyrosine, and phosphohistidine

21 January 2018

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21 January 2018

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21 January 2018

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Profiling phosphoproteins of yeast mitochondria reveals a role of phosphorylation in assembly of the ATP synthase

21 January 2018

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Phosphoproteome of resting human platelets

21 January 2018

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A dimeric 14-3-3 protein is an essential cofactor for Raf kinase activity

21 January 2018

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Dephosphorylation of Ser-259 regulates Raf-1 membrane association

21 January 2018

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Identification of novel ERK-mediated feedback phosphorylation sites at the C-terminus of B-Raf

21 January 2018

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Epidermal growth factor (EGF) stimulates association and kinase activity of Raf-1 with the EGF receptor

21 January 2018

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14-3-3 proteins: active cofactors in cellular regulation by serine/threonine phosphorylation

21 January 2018

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21 January 2018

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Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF

21 January 2018

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21 January 2018

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Constitutive activation of the Ras-Raf signaling pathway in metastatic melanoma is associated with poor prognosis

21 January 2018

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Mutations of the BRAF gene in human cancer

21 January 2018

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Mutations of C-RAF are rare in human cancer because C-RAF has a low basal kinase activity compared with B-RAF

21 January 2018

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Negative regulation of the serine/threonine kinase B-Raf by Akt

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M801782200

Raf activation is regulated by tyrosine 510 phosphorylation in Drosophila

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M801782200

Raf-1 kinase possesses distinct binding domains for phosphatidylserine and phosphatidic acid. Phosphatidic acid regulates the translocation of Raf-1 in 12-O-tetradecanoylphorbol-13-acetate-stimulated Madin-Darby canine kidney cells

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M801782200

The recruitment of Raf-1 to membranes is mediated by direct interaction with phosphatidic acid and is independent of association with Ras.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M801782200

Mutational analysis of Raf-1 cysteine rich domain: requirement for a cluster of basic aminoacids for interaction with phosphatidylserine.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M801782200

Identification of key residues in the A-Raf kinase important for phosphoinositide lipid binding specificity.

21 January 2018

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Novel raf kinase protein-protein interactions found by an exhaustive yeast two-hybrid analysis

21 January 2018

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Kinase-regulated quantal assemblies and kiss-and-run recycling of caveolae

21 January 2018

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21 January 2018

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Negative Modulation of Membrane Localization of the Raf-1 Protein Kinase by Hyperphosphorylation

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M801782200

21 January 2018

Identifiers

DOI

10.1074/JBC.M801782200

1 reference

22 December 2017

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22 December 2017