(Q46307051)

21 December 2017

review article

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title

Mapping normal and cancer cell signalling networks: towards single-cell proteomics (English)

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21 December 2017

main subject

single-cell proteomics

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21 December 2017

Garry P. Nolan

series ordinal

object named as

Garry P Nolan

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21 December 2017

author name string

Nikesh Kotecha

series ordinal

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21 December 2017

language of work or name

English

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publication date

1 February 2006

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21 December 2017

published in

Nature Reviews Cancer

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21 December 2017

volume

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21 December 2017

issue

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21 December 2017

page(s)

146-155

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21 December 2017

Intracellular phospho-protein staining techniques for flow cytometry: monitoring single cell signaling events

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Single cell profiling of potentiated phospho-protein networks in cancer cells.

21 January 2018

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Idiotype-pulsed dendritic cell vaccination for B-cell lymphoma: clinical and immune responses in 35 patients

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Analyzing cellular biochemistry in terms of molecular networks

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High-throughput mapping of a dynamic signaling network in mammalian cells

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The Hallmarks of Cancer

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Cell signaling and cancer

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Killing time for cancer cells

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Abnormal B lymphocyte development, activation, and differentiation in mice that lack or overexpress the CD19 signal transduction molecule.

21 January 2018

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Causal protein-signaling networks derived from multiparameter single-cell data

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Chemical genetics identifies Rab geranylgeranyl transferase as an apoptotic target of farnesyl transferase inhibitors

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Imatinib targets other than bcr/abl and their clinical relevance in myeloid disorders

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IFNgamma and lymphocytes prevent primary tumour development and shape tumour immunogenicity

21 January 2018

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STAT proteins: From normal control of cellular events to tumorigenesis

21 January 2018

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STAT-1 interacts with p53 to enhance DNA damage-induced apoptosis

21 January 2018

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STI571 (Gleevec) as a paradigm for cancer therapy

21 January 2018

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Analysis of protein phosphorylation and cellular signaling events by flow cytometry: techniques and clinical applications

21 January 2018

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Whole blood fixation and permeabilization protocol with red blood cell lysis for flow cytometry of intracellular phosphorylated epitopes in leukocyte subpopulations

21 January 2018

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Prediction of Survival in Follicular Lymphoma Based on Molecular Features of Tumor-Infiltrating Immune Cells

21 January 2018

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Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion

21 January 2018

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The pathophysiologic role of VEGF in hematologic malignancies: therapeutic implications

21 January 2018

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The three Es of cancer immunoediting

21 January 2018

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c-Kit receptor (CD117) expression on myeloblasts and white blood cell counts in acute myeloid leukemia

21 January 2018

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Phenotypic characterization of the human myeloma cell growth fraction

21 January 2018

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21 January 2018

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Comparison of cell viability probes compatible with fixation and permeabilization for combined surface and intracellular staining in flow cytometry

21 January 2018

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Histone H3 phosphorylation and expression of cyclins A and B1 measured in individual cells during their progression through G2 and mitosis

21 January 2018

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Cell division rates of primary human precursor B cells in culture reflect in vivo rates

21 January 2018

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Flow cytometric immunophenotyping including Bcl-2 detection on fine needle aspirates in the diagnosis of reactive lymphadenopathy and non-Hodgkin's lymphoma

21 January 2018

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Quantitation of biological tumor markers (p53, c-myc, Ki-67 and DNA ploidy) by multiparameter flow cytometry in non-small-cell lung cancer

21 January 2018

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p53 status of newly established acute myeloid leukaemia cell lines

21 January 2018

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Monoclonal antibody specific for an activated RAS protein

21 January 2018

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Role of glutathione depletion and reactive oxygen species generation in apoptotic signaling in a human B lymphoma cell line.

21 January 2018

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Flow cytometric determination of glutathione in clinical samples.

21 January 2018

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Characterization of circulating T cells specific for tumor-associated antigens in melanoma patients

21 January 2018

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Homeostatic chemokines drive migration of malignant B cells in patients with non-Hodgkin lymphomas

21 January 2018

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Quantification and cytokine production of circulating lymphoid and myeloid cells in acute myelogenous leukaemia.

21 January 2018

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The presence of a FLT3 internal tandem duplication in patients with acute myeloid leukemia (AML) adds important prognostic information to cytogenetic risk group and response to the first cycle of chemotherapy: analysis of 854 patients from the Unite

21 January 2018

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Mutations of the BRAF gene in human cancer

21 January 2018

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Constitutive activation of the Ras-Raf signaling pathway in metastatic melanoma is associated with poor prognosis

21 January 2018

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Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF

21 January 2018

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HER2/neu as a predictive factor in breast cancer

21 January 2018

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The efficacy of Herceptin therapies is influenced by the expression of other erbB receptors, their ligands and the activation of downstream signalling proteins

21 January 2018

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HER-2/neu blocks tumor necrosis factor-induced apoptosis via the Akt/NF-kappaB pathway

21 January 2018

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Signal transducer and activator of transcription (STAT)5 activation by BCR/ABL is dependent on intact Src homology (SH)3 and SH2 domains of BCR/ABL and is required for leukemogenesis

21 January 2018

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Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification

21 January 2018

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Roots of clinical resistance to STI-571 cancer therapy

21 January 2018

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Targeting c-Kit mutations: basic science to novel therapies

21 January 2018

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PDGF receptors as cancer drug targets

21 January 2018

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The role of FLT3 in haematopoietic malignancies

21 January 2018

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Mechanisms of B-cell lymphoma pathogenesis

21 January 2018

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The role of TGF-beta and Wnt signaling in gastrointestinal stem cells and cancer

21 January 2018

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The new kid on the block(ade) of the IGF-1 receptor

21 January 2018

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Hedgehog signalling in cancer formation and maintenance

21 January 2018

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Gli and hedgehog in cancer: tumours, embryos and stem cells.

21 January 2018

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The discovery of receptor tyrosine kinases: targets for cancer therapy

21 January 2018

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Molecular mechanisms underlying ErbB2/HER2 action in breast cancer

21 January 2018

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Role of STATs as downstream signal transducers in Src family kinase-mediated tumorigenesis

21 January 2018

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Divergent roles of STAT1 and STAT5 in malignancy as revealed by gene disruptions in mice

21 January 2018

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The STATs of cancer--new molecular targets come of age

21 January 2018

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NF1 tumor suppressor gene function: narrowing the GAP

21 January 2018

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Targeting RAS signalling pathways in cancer therapy

21 January 2018

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ZAP-70 compared with immunoglobulin heavy-chain gene mutation status as a predictor of disease progression in chronic lymphocytic leukemia

21 January 2018

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c-MYC: more than just a matter of life and death

21 January 2018

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The phosphatidylinositol 3-Kinase AKT pathway in human cancer

21 January 2018

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Targeting death and decoy receptors of the tumour-necrosis factor superfamily

21 January 2018

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NF-kappaB: linking inflammation and immunity to cancer development and progression

21 January 2018

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The p53 pathway: positive and negative feedback loops

21 January 2018

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The Bcl2 family: regulators of the cellular life-or-death switch

21 January 2018

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Role of integrins in cell invasion and migration

21 January 2018

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Wnt signalling in stem cells and cancer

21 January 2018

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Convergence of Wnt, beta-catenin, and cadherin pathways

21 January 2018

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21 January 2018

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Seventeen-colour flow cytometry: unravelling the immune system

21 January 2018

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Proliferative response of mantle cell lymphoma cells stimulated by CD40 ligation and IL-4

31 March 2020

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Flow cytometry detection of caspase 3 activation in preapoptotic leukemic cells

31 March 2020

1 reference

K-ras oncogene activation as a prognostic marker in adenocarcinoma of the lung

31 March 2020

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Lack of constitutive activation of MAP kinase pathway in human acute myeloid leukemia cells with N-Ras mutation

31 March 2020

1 reference

Constitutive activity of signal transducer and activator of transcription 3 protein in acute myeloid leukemia blasts is associated with short disease-free survival

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRC1804

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21 December 2017

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21 December 2017