(Q46375530)

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Complete rescue of cerebrovascular function in aged Alzheimer's disease transgenic mice by antioxidants and pioglitazone, a peroxisome proliferator-activated receptor gamma agonist

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Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/18784309

Complete rescue of cerebrovascular function in aged Alzheimer's disease transgenic mice by antioxidants and pioglitazone, a peroxisome proliferator-activated receptor gamma agonist (English)

1 reference

Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/18784309

Alzheimer's disease

0 references

Clotilde Lecrux

4

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6670922&resulttype=core&format=json

16 May 2020

Pedro Rosa-Neto

6

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6670922&resulttype=core&format=json

16 May 2020

author name string

Nektaria Nicolakakis

1

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6670922&resulttype=core&format=json

16 May 2020

Tahar Aboulkassim

2

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6670922&resulttype=core&format=json

16 May 2020

Brice Ongali

3

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6670922&resulttype=core&format=json

16 May 2020

Priscilla Fernandes

5

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6670922&resulttype=core&format=json

16 May 2020

Xin-Kang Tong

7

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6670922&resulttype=core&format=json

16 May 2020

Edith Hamel

8

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6670922&resulttype=core&format=json

16 May 2020

language of work or name

0 references

publication date

1 September 2008

1 reference

Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/18784309

Journal of Neuroscience

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6670922&resulttype=core&format=json

16 May 2020

28

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6670922&resulttype=core&format=json

16 May 2020

37

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6670922&resulttype=core&format=json

16 May 2020

9287-9296

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6670922&resulttype=core&format=json

16 May 2020

describes a project that uses

1 reference

Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC6670922/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

SOD1 rescues cerebral endothelial dysfunction in mice overexpressing amyloid precursor protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/18784309

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regional cholinergic denervation of cortical microvessels and nitric oxide synthase-containing neurons in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/18784309

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

High-level neuronal expression of abeta 1-42 in wild-type human amyloid protein precursor transgenic mice: synaptotoxicity without plaque formation

1 reference

https://pubmed.ncbi.nlm.nih.gov/18784309

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vivo imaging of neuronal activation and plasticity in the rat brain by high resolution positron emission tomography (microPET)

1 reference

https://pubmed.ncbi.nlm.nih.gov/18784309

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of cerebral ischemia in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/18784309

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Abeta 1-40-related reduction in functional hyperemia in mouse neocortex during somatosensory activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/18784309

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The ligands/activators for peroxisome proliferator-activated receptor alpha (PPARalpha) and PPARgamma increase Cu2+,Zn2+-superoxide dismutase and decrease p22phox message expressions in primary endothelial cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/18784309

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Brain vessels normally undergo cyclic activation and inactivation: evidence from tumor necrosis factor-alpha, heme oxygenase-1, and manganese superoxide dismutase immunostaining of vessels and perivascular brain cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/18784309

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Peroxynitrite reduces vasodilatory responses to reduced intravascular pressure, calcitonin gene-related peptide, and cromakalim in isolated middle cerebral arteries

1 reference

https://pubmed.ncbi.nlm.nih.gov/18784309

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The SOD mimetic tempol restores vasodilation in afferent arterioles of experimental diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/18784309

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of chronic N-acetylcysteine treatment on the actions of peroxynitrite on aortic vascular reactivity in hypertensive rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/18784309

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Relationship between metabolic dysfunctions, gene responses and delayed cell death after mild focal cerebral ischemia in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/18784309

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Controlled trial of N-acetylcysteine for patients with probable Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/18784309

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Positron emission tomography in evaluation of dementia: Regional brain metabolism and long-term outcome

1 reference

https://pubmed.ncbi.nlm.nih.gov/18784309

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structure, endothelial function, cell growth, and inflammation in blood vessels of angiotensin II-infused rats: role of peroxisome proliferator-activated receptor-gamma

1 reference

https://pubmed.ncbi.nlm.nih.gov/18784309

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cerebrovascular autoregulation is profoundly impaired in mice overexpressing amyloid precursor protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/18784309

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alzheimer's disease and the basal forebrain cholinergic system: relations to beta-amyloid peptides, cognition, and treatment strategies

1 reference

https://pubmed.ncbi.nlm.nih.gov/18784309

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuron-to-astrocyte signaling is central to the dynamic control of brain microcirculation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18784309

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The antioxidants alpha-lipoic acid and N-acetylcysteine reverse memory impairment and brain oxidative stress in aged SAMP8 mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/18784309

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Adult mouse astrocytes degrade amyloid-beta in vitro and in situ

1 reference

https://pubmed.ncbi.nlm.nih.gov/18784309

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reversal of age-related learning deficits and brain oxidative stress in mice with superoxide dismutase/catalase mimetics

1 reference

https://pubmed.ncbi.nlm.nih.gov/18784309

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuronal depletion of calcium-dependent proteins in the dentate gyrus is tightly linked to Alzheimer's disease-related cognitive deficits

1 reference

https://pubmed.ncbi.nlm.nih.gov/18784309

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Anti-inflammatory drug therapy alters beta-amyloid processing and deposition in an animal model of Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18784309

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chronic cerebrovascular insufficiency induces dementia-like deficits in aged rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/18784309

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Age-dependent cerebrovascular abnormalities and blood flow disturbances in APP23 mice modeling Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18784309

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PPARγ activation, by reducing oxidative stress, increases NO bioavailability in coronary arterioles of mice with Type 2 diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/18784309

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cholinergic modulation of the cortical microvascular bed.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18784309

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Is Alzheimer's disease a neurodegenerative or a vascular disorder? Data, dogma, and dialectics

1 reference

https://pubmed.ncbi.nlm.nih.gov/18784309

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

MCI conversion to dementia and the APOE genotype: a prediction study with FDG-PET.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18784309

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

NADPH-oxidase-derived reactive oxygen species mediate the cerebrovascular dysfunction induced by the amyloid beta peptide.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18784309

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selective cholinergic denervation, independent from oxidative stress, in a mouse model of Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/18784309

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurovascular mechanisms of Alzheimer's neurodegeneration

1 reference

https://pubmed.ncbi.nlm.nih.gov/18784309

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Acute treatment with the PPARgamma agonist pioglitazone and ibuprofen reduces glial inflammation and Abeta1-42 levels in APPV717I transgenic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/18784309

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Vitamin E and donepezil for the treatment of mild cognitive impairment

1 reference

https://pubmed.ncbi.nlm.nih.gov/18784309

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cerebral hypoperfusion and clinical onset of dementia: the Rotterdam Study

1 reference

https://pubmed.ncbi.nlm.nih.gov/18784309

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuroanatomical differences between mouse strains as shown by high-resolution 3D MRI

1 reference

https://pubmed.ncbi.nlm.nih.gov/18784309

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Preserved cognition in patients with early Alzheimer disease and amnestic mild cognitive impairment during treatment with rosiglitazone: a preliminary study

1 reference

https://pubmed.ncbi.nlm.nih.gov/18784309

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Short-term pioglitazone treatment improves vascular function irrespective of metabolic changes in patients with type 2 diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/18784309

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Vascular remodeling versus amyloid beta-induced oxidative stress in the cerebrovascular dysfunctions associated with Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18784309

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reduced density of neuropeptide Y neurons in the somatosensory cortex of old male and female rats: relation to cholinergic depletion and recovery after nerve growth factor treatment.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18784309

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Endothelial influences on cerebrovascular tone

1 reference

https://pubmed.ncbi.nlm.nih.gov/18784309

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurovascular coupling in the normal brain and in hypertension, stroke, and Alzheimer disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/18784309

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Efficacy of rosiglitazone in a genetically defined population with mild-to-moderate Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/18784309

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Perivascular nerves and the regulation of cerebrovascular tone

1 reference

https://pubmed.ncbi.nlm.nih.gov/18784309

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rosiglitazone attenuates learning and memory deficits in Tg2576 Alzheimer mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/18784309

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A specific amyloid-beta protein assembly in the brain impairs memory

1 reference

https://pubmed.ncbi.nlm.nih.gov/18784309

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Deglycosylated anti-amyloid-beta antibodies eliminate cognitive deficits and reduce parenchymal amyloid with minimal vascular consequences in aged amyloid precursor protein transgenic mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18784309

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Astrocyte control of synaptic transmission and neurovascular coupling.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18784309

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chronic administration of pioglitazone attenuates intracerebroventricular streptozotocin induced-memory impairment in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/18784309

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Therapeutic rescue of neurodegeneration in experimental type 3 diabetes: relevance to Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/18784309

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of NAD(P)H oxidase alleviates impaired NOS-dependent responses of pial arterioles in type 1 diabetes mellitus

1 reference

https://pubmed.ncbi.nlm.nih.gov/18784309

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin protects against stress-induced impairments in water maze performance

1 reference

https://pubmed.ncbi.nlm.nih.gov/18784309

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hypoxia facilitates Alzheimer's disease pathogenesis by up-regulating BACE1 gene expression

1 reference

https://pubmed.ncbi.nlm.nih.gov/18784309

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The PPARgamma ligand, rosiglitazone, reduces vascular oxidative stress and NADPH oxidase expression in diabetic mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18784309

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Elevated plasma cholesterol does not affect brain Abeta in mice lacking the low-density lipoprotein receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/18784309

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxidative stress and aberrant signaling in aging and cognitive decline

1 reference

https://pubmed.ncbi.nlm.nih.gov/18784309

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Drug insight: effects mediated by peroxisome proliferator-activated receptor-gamma in CNS disorders

1 reference

https://pubmed.ncbi.nlm.nih.gov/18784309

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxidative stress and cerebrovascular dysfunction in mouse models of Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/18784309

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nox2-derived radicals contribute to neurovascular and behavioral dysfunction in mice overexpressing the amyloid precursor protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/18784309

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The common environmental pollutant dioxin-induced memory deficits by altering estrogen pathways and a major route of retinol transport involving transthyretin

1 reference

https://pubmed.ncbi.nlm.nih.gov/18784309

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction of manganous superoxide dismutase by tumor necrosis factor: possible protective mechanism

1 reference

https://pubmed.ncbi.nlm.nih.gov/18784309

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Developments of a water-maze procedure for studying spatial learning in the rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/18784309

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of ATP-sensitive K+ channels in CGRP-induced dilatation of basilar artery in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/18784309

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Two-week administration of tempol attenuates both hypertension and renal excretion of 8-Iso prostaglandin f2alpha

1 reference

https://pubmed.ncbi.nlm.nih.gov/18784309

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.3348-08.2008

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6670922&resulttype=core&format=json

16 May 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6670922&resulttype=core&format=json

16 May 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6670922&resulttype=core&format=json

16 May 2020

ResearchGate publication ID

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