(Q46240526)

20 December 2017

title

Etazolate, a neuroprotective drug linking GABA(A) receptor pharmacology to amyloid precursor protein processing (English)

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20 December 2017

main subject

etazolate

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ChEBI release 2020-05-28

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Maryline Marcade

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20 December 2017

Jérôme Bourdin

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20 December 2017

Nadia Loiseau

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20 December 2017

Hélène Peillon

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20 December 2017

Aurélie Rayer

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20 December 2017

Dominique Drouin

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20 December 2017

Fabien Schweighoffer

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20 December 2017

Laurent Désiré

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20 December 2017

language of work or name

English

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publication date

1 July 2008

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20 December 2017

Journal of Neurochemistry

published in

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20 December 2017

volume

106

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20 December 2017

issue

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20 December 2017

page(s)

392-404

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20 December 2017

BACE1- and BACE2-expressing human cells: characterization of beta-amyloid precursor protein-derived catabolites, design of a novel fluorimetric assay, and identification of new in vitro inhibitors

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Role of the APP non-amyloidogenic signaling pathway and targeting alpha-secretase as an alternative drug target for treatment of Alzheimer's disease.

21 January 2018

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Guinea pigs as a nontransgenic model for APP processing in vitro and in vivo

21 January 2018

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The amyloid pathology progresses in a neurotransmitter-specific manner

21 January 2018

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Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo

21 January 2018

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Enigmatic GABAergic networks in adult neurogenic zones

21 January 2018

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Soluble form of amyloid precursor protein regulates proliferation of progenitors in the adult subventricular zone.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05396.X

sAPPalpha enhances the transdifferentiation of adult bone marrow progenitor cells to neuronal phenotypes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05396.X

ERK1/2 activation mediates Abeta oligomer-induced neurotoxicity via caspase-3 activation and tau cleavage in rat organotypic hippocampal slice cultures

21 January 2018

1 reference

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Acute gamma-secretase inhibition improves contextual fear conditioning in the Tg2576 mouse model of Alzheimer's disease.

21 January 2018

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An inverse agonist selective for alpha5 subunit-containing GABAA receptors enhances cognition.

21 January 2018

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RAC1 inhibition targets amyloid precursor protein processing by gamma-secretase and decreases Abeta production in vitro and in vivo.

21 January 2018

1 reference

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Tumor necrosis factor-alpha converting enzyme is processed by proprotein-convertases to its mature form which is degraded upon phorbol ester stimulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05396.X

Increase in extracellular NCAM and amyloid precursor protein following induction of long-term potentiation in the dentate gyrus of anaesthetized rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05396.X

Activation of muscarinic receptors inhibits beta-amyloid peptide-induced signaling in cortical slices

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05396.X

Involvement of c-Jun N-terminal kinase in amyloid precursor protein-mediated neuronal cell death.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05396.X

Synaptic changes in Alzheimer's disease: increased amyloid-beta and gliosis in surviving terminals is accompanied by decreased PSD-95 fluorescence

21 January 2018

1 reference

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Furin is an endogenous regulator of alpha-secretase associated APP processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05396.X

Acceleration of amyloid beta-peptide aggregation by physiological concentrations of calcium

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05396.X

APP processing and synaptic function

21 January 2018

1 reference

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A neural cell adhesion molecule-derived peptide reduces neuropathological signs and cognitive impairment induced by Abeta25-35.

21 January 2018

1 reference

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Decreased α-secretase-cleaved amyloid precursor protein as a diagnostic marker for Alzheimer's diseas

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05396.X

Chronic stimulation of GABAA receptor with muscimol reduces amyloid beta protein (25-35)-induced neurotoxicity in cultured rat cortical cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05396.X

Neuroprotection by D-securinine against neurotoxicity induced by beta-amyloid (25-35).

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05396.X

Taurine prevents the neurotoxicity of beta-amyloid and glutamate receptor agonists: activation of GABA receptors and possible implications for Alzheimer's disease and other neurological disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05396.X

Crosstalk between Rap1 and Rac regulates secretion of sAPPalpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05396.X

Synapse-associated protein-97 mediates alpha-secretase ADAM10 trafficking and promotes its activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05396.X

Evidence for excitoprotective and intraneuronal calcium-regulating roles for secreted forms of the beta-amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05396.X

Memory-enhancing effects of secreted forms of the beta-amyloid precursor protein in normal and amnestic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05396.X

Molecular regulation of cognitive functions and developmental plasticity: impact of GABAA receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05396.X

Enhancement of working memory performance in the rat by MDL 26,479, a novel compound with activity at the GABAA receptor complex.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05396.X

Functional modulation of GABAA receptors by cAMP-dependent protein phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05396.X

Alpha- and beta-secretase activity as a function of age and beta-amyloid in Down syndrome and normal brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05396.X

Release of Alzheimer amyloid precursor derivatives stimulated by activation of muscarinic acetylcholine receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05396.X

Release of amyloid beta-protein precursor derivatives by electrical depolarization of rat hippocampal slices

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05396.X

Regulation of APP cleavage by alpha-, beta- and gamma-secretases

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05396.X

Aberrant excitatory neuronal activity and compensatory remodeling of inhibitory hippocampal circuits in mouse models of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05396.X

Pharmacology of pyrazolopyridines

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05396.X

The secreted beta-amyloid precursor protein ectodomain APPs alpha is sufficient to rescue the anatomical, behavioral, and electrophysiological abnormalities of APP-deficient mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05396.X

Regulation of the amyloid precursor protein ectodomain shedding by the 5-HT4 receptor and Epac.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05396.X

A monoclonal antibody to amyloid precursor protein induces neuronal apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05396.X

GABA receptors ameliorate Hcy-mediated integrin shedding and constrictive collagen remodeling in microvascular endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05396.X

Amyloid beta peptide adversely affects spine number and motility in hippocampal neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05396.X

Neutralization of transthyretin reverses the neuroprotective effects of secreted amyloid precursor protein (APP) in APPSW mice resulting in tau phosphorylation and loss of hippocampal neurons: support for the amyloid hypothesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05396.X

Tracazolate reveals a novel type of allosteric interaction with recombinant gamma-aminobutyric acid(A) receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05396.X

Roles of amyloid precursor protein and its fragments in regulating neural activity, plasticity and memory

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05396.X

Cholesterol-dependent gamma-secretase activity in buoyant cholesterol-rich membrane microdomains

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05396.X

Expression, purification, and characterization of human cAMP-specific phosphodiesterase (PDE4) subtypes A, B, C, and D.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05396.X

A Novel γ-Secretase Assay Based on Detection of the Putative C-terminal Fragment-γ of Amyloid β Protein Precursor

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05396.X

10.1111/J.1471-4159.2008.05396.X

21 January 2018

Identifiers

DOI

1 reference

20 December 2017

1 reference

20 December 2017