(Q45009703)

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Pancreatic islets from cyclin-dependent kinase 4/R24C (Cdk4) knockin mice have significantly increased beta cell mass and are physiologically functional, indicating that Cdk4 is a potential target for pancreatic beta cell mass regeneration in Type 1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15298346%20AND%20SRC:MED&resulttype=core&format=json

31 December 2019

Pancreatic islets from cyclin-dependent kinase 4/R24C (Cdk4) knockin mice have significantly increased beta cell mass and are physiologically functional, indicating that Cdk4 is a potential target for pancreatic beta cell mass regeneration in Type 1 diabetes (English)

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31 December 2019

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31 December 2019

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N Marzo

1

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31 December 2019

M E Fabregat

3

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31 December 2019

J Martín

4

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31 December 2019

E F Usac

5

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31 December 2019

C Franco

6

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31 December 2019

M Barbacid

7

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31 December 2019

R Gomis

8

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31 December 2019

publication date

1 April 2004

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31 December 2019

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31 December 2019

47

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31 December 2019

4

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31 December 2019

686-694

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31 December 2019

Mechanisms involved in the beta-cell mass increase induced by chronic sucrose feeding to normal rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/15298346

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Overexpression of hexokinase I in isolated islets of Langerhans via recombinant adenovirus. Enhancement of glucose metabolism and insulin secretion at basal but not stimulatory glucose levels

1 reference

https://pubmed.ncbi.nlm.nih.gov/15298346

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A p16INK4a-insensitive CDK4 mutant targeted by cytolytic T lymphocytes in a human melanoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/15298346

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Functional analysis of a conditionally transformed pancreatic beta-cell line

1 reference

https://pubmed.ncbi.nlm.nih.gov/15298346

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Efficient transfer, integration, and sustained long-term expression of the transgene in adult rat brains injected with a lentiviral vector

1 reference

https://pubmed.ncbi.nlm.nih.gov/15298346

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of local and systemic macrophage blocking on engraftment of allogeneic porcine islets

1 reference

https://pubmed.ncbi.nlm.nih.gov/15298346

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanisms of mitogenic and anti-apoptotic signaling by glucose-dependent insulinotropic polypeptide in beta(INS-1)-cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/15298346

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lentivirus-mediated Bcl-2 expression in betaTC-tet cells improves resistance to hypoxia and cytokine-induced apoptosis while preserving in vitro and in vivo control of insulin secretion

1 reference

https://pubmed.ncbi.nlm.nih.gov/15298346

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin independence after islet transplantation into type I diabetic patient

1 reference

https://pubmed.ncbi.nlm.nih.gov/15298346

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

P2 receptor agonists stimulate insulin release from human pancreatic islets

1 reference

https://pubmed.ncbi.nlm.nih.gov/15298346

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of glucose in the in vitro regulation of cell cycle kinetics and proliferation of fetal pancreatic B-cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/15298346

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector

1 reference

https://pubmed.ncbi.nlm.nih.gov/15298346

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Wide spectrum of tumors in knock-in mice carrying a Cdk4 protein insensitive to INK4 inhibitors.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15298346

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Loss of Cdk4 expression causes insulin-deficient diabetes and Cdk4 activation results in beta-islet cell hyperplasia

1 reference

https://pubmed.ncbi.nlm.nih.gov/15298346

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen

1 reference

https://pubmed.ncbi.nlm.nih.gov/15298346

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Functional properties of isolated human pancreatic islets beneficial effects of culture and exposure to high glucose concentrations

1 reference

https://pubmed.ncbi.nlm.nih.gov/15298346

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxidative stress induces p21 expression in pancreatic islet cells: possible implication in beta-cell dysfunction

1 reference

https://pubmed.ncbi.nlm.nih.gov/15298346

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4

1 reference

https://pubmed.ncbi.nlm.nih.gov/15298346

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Improved allograft survival using highly enriched populations of rat islets

1 reference

https://pubmed.ncbi.nlm.nih.gov/15298346

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genetic rescue of Cdk4 null mice restores pancreatic beta-cell proliferation but not homeostatic cell number

1 reference

https://pubmed.ncbi.nlm.nih.gov/15298346

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Targeted disruption of CDK4 delays cell cycle entry with enhanced p27(Kip1) activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/15298346

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neogenesis vs. apoptosis As main components of pancreatic beta cell ass changes in glucose-infused normal and mildly diabetic adult rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/15298346

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reduction of islet amylin expression and basal secretion by adenovirus-mediated delivery of amylin antisense cDNA.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15298346

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Association of cyclin-dependent kinase-4 and cyclin D1 in neonatal beta cells after mitogenic stimulation by lysophosphatidic acid

1 reference

https://pubmed.ncbi.nlm.nih.gov/15298346

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Principles of CDK regulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/15298346

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin-secreting cells derived from embryonic stem cells normalize glycemia in streptozotocin-induced diabetic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/15298346

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S00125-004-1372-0

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15298346%20AND%20SRC:MED&resulttype=core&format=json

31 December 2019

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Europe PubMed Central

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31 December 2019

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