(Q45092703)

9 December 2017

title

Amplification of IFN-alpha-induced STAT1 activation and inflammatory function by Syk and ITAM-containing adaptors (English)

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9 December 2017

Xiaoyu Hu

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Lionel B Ivashkiv

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9 December 2017

Clifford A Lowell

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9 December 2017

Ioannis Tassiulas

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9 December 2017

Hao Ho

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9 December 2017

Yogita Kashyap

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9 December 2017

Paul Paik

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9 December 2017

Yongmei Hu

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9 December 2017

language of work or name

English

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publication date

3 October 2004

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9 December 2017

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9 December 2017

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9 December 2017

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9 December 2017

page(s)

1181-1189

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How cells respond to interferons

9 December 2017

cites work

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Interferons alpha and beta as immune regulators--a new look

21 January 2018

1 reference

Stats: transcriptional control and biological impact

21 January 2018

1 reference

Targeted disruption of the mouse Stat1 gene results in compromised innate immunity to viral disease

21 January 2018

1 reference

Targeted disruption of the Stat1 gene in mice reveals unexpected physiologic specificity in the JAK-STAT signaling pathway

21 January 2018

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Role of the cytoplasmic domains of the type I interferon receptor subunits in signaling

21 January 2018

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IFN-lambdas mediate antiviral protection through a distinct class II cytokine receptor complex

21 January 2018

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IL-28, IL-29 and their class II cytokine receptor IL-28R

21 January 2018

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Interferon-alpha activates signal transducers and activators of transcription 5 and 6 in Daudi cells

21 January 2018

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Role of STAT5 in interferon-alpha signal transduction in Ba/F3 cells

21 January 2018

1 reference

Recruitment of Stat4 to the human interferon-alpha/beta receptor requires activated Stat2

21 January 2018

1 reference

A weak signal for strong responses: interferon-alpha/beta revisited

21 January 2018

1 reference

Differential viral induction of distinct interferon-alpha genes by positive feedback through interferon regulatory factor-7

21 January 2018

1 reference

Distinct and essential roles of transcription factors IRF-3 and IRF-7 in response to viruses for IFN-alpha/beta gene induction

21 January 2018

1 reference

Cross talk of the interferon-alpha/beta signalling complex with gp130 for effective interleukin-6 signalling

21 January 2018

1 reference

The Cell Biology of Macrophage Activation

21 January 2018

1 reference

Interferon-γ: an overview of signals, mechanisms and functions

21 January 2018

1 reference

Tyrosine kinase SYK: essential functions for immunoreceptor signalling

21 January 2018

1 reference

21 January 2018

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The immunomodulatory adapter proteins DAP12 and Fc receptor gamma-chain (FcRgamma) regulate development of functional osteoclasts through the Syk tyrosine kinase

21 January 2018

1 reference

Costimulatory signals mediated by the ITAM motif cooperate with RANKL for bone homeostasis

21 January 2018

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Inhibition of beta 2 integrin receptor and Syk kinase signaling in monocytes by the Src family kinase Fgr

21 January 2018

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Syk is required for integrin signaling in neutrophils

21 January 2018

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Functional and physical interactions of Syk family kinases with the Vav proto-oncogene product

21 January 2018

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The IL-15R alpha chain signals through association with Syk in human B cells

21 January 2018

1 reference

Hierarchy of protein tyrosine kinases in interleukin-2 (IL-2) signaling: activation of syk depends on Jak3; however, neither Syk nor Lck is required for IL-2-mediated STAT activation

21 January 2018

1 reference

Protein tyrosine kinase Syk is associated with and activated by the IL-2 receptor: possible link with the c-myc induction pathway

21 January 2018

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Cooperative binding of Stat1-2 heterodimers and ISGF3 to tandem DNA elements

21 January 2018

1 reference

Biologic consequences of Stat1-independent IFN signaling.

21 January 2018

1 reference

Stat1-independent regulation of gene expression in response to IFN-gamma

21 January 2018

1 reference

Type I interferon modulation of cellular responses to cytokines and infectious pathogens: potential role in SLE pathogenesis

21 January 2018

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Tyk2 plays a restricted role in IFN alpha signaling, although it is required for IL-12-mediated T cell function

21 January 2018

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Partial impairment of cytokine responses in Tyk2-deficient mice

21 January 2018

1 reference

Central role for type I interferons and Tyk2 in lipopolysaccharide-induced endotoxin shock

21 January 2018

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Functional subdomains of STAT2 required for preassociation with the alpha interferon receptor and for signaling

21 January 2018

1 reference

Role of STAT2 in the alpha interferon signaling pathway

21 January 2018

1 reference

Selective loss of type I interferon-induced STAT4 activation caused by a minisatellite insertion in mouse Stat2.

21 January 2018

1 reference

Differential regulation of the alpha/beta interferon-stimulated Jak/Stat pathway by the SH2 domain-containing tyrosine phosphatase SHPTP1

21 January 2018

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Perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk

21 January 2018

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Toll-like receptors induce a phagocytic gene program through p38.

21 January 2018

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Reprogramming of IL-10 activity and signaling by IFN-gamma.

21 January 2018

1 reference

IFN-alpha priming results in a gain of proinflammatory function by IL-10: implications for systemic lupus erythematosus pathogenesis

21 January 2018

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Activation of the STAT1 pathway in rheumatoid arthritis

21 January 2018

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Rheumatoid arthritis is a heterogeneous disease: evidence for differences in the activation of the STAT-1 pathway between rheumatoid tissues

21 January 2018

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Interferon-inducible gene expression signature in peripheral blood cells of patients with severe lupus

21 January 2018

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Interferon and granulopoiesis signatures in systemic lupus erythematosus blood

21 January 2018

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Monocyte response to Th1 stimulation and effector function toward human mesangial cells are not impaired in patients with lupus nephritis

21 January 2018

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Negative regulation of cytokine signaling pathways

21 January 2018

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Protein ISGylation modulates the JAK-STAT signaling pathway

21 January 2018

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Inhibition of interleukin 2 signaling and signal transducer and activator of transcription (STAT)5 activation during T cell receptor-mediated feedback inhibition of T cell expansion

21 January 2018

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A completely foreign receptor can mediate an interferon-gamma-like response

21 January 2018

1 reference

A lentivirus-based system to functionally silence genes in primary mammalian cells, stem cells and transgenic mice by RNA interference

21 January 2018

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Antiproliferative action of interferon-α requires components of T-cell-receptor signalling

21 January 2018

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Cross talk between interferon-gamma and -alpha/beta signaling components in caveolar membrane domains

21 January 2018

1 reference

7 January 2021

Sensitization of IFN-γ Jak-STAT signaling during macrophage activation

1 reference

7 January 2021

Cytoplasmic activation of ISGF3, the positive regulator of interferon-alpha-stimulated transcription, reconstituted in vitro

1 reference

7 January 2021

Immune response in Stat2 knockout mice

1 reference

7 January 2021

Critical role for STAT4 activation by type 1 interferons in the interferon-gamma response to viral infection

1 reference

7 January 2021

Identifiers

DOI

10.1038/NI1126

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9 December 2017

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