(Q45084169)

English

Myoloid-related protein 8, an endogenous ligand of Toll-like receptor 4, is involved in epileptogenesis of mesial temporal lobe epilepsy via activation of the nuclear factor-κB pathway in astrocytes

scientific article published on 28 August 2013

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Europe PubMed Central

PubMed publication ID

9 December 2017

Myoloid-related protein 8, an endogenous ligand of Toll-like receptor 4, is involved in epileptogenesis of mesial temporal lobe epilepsy via activation of the nuclear factor-κB pathway in astrocytes (English)

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Europe PubMed Central

PubMed publication ID

9 December 2017

toll-like receptor

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temporal lobe epilepsy

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author name string

Na Gan

1

1 reference

Europe PubMed Central

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9 December 2017

Lifen Yang

2

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Europe PubMed Central

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9 December 2017

Ahmed Omran

3

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Europe PubMed Central

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9 December 2017

Jing Peng

4

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9 December 2017

Liwen Wu

5

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Europe PubMed Central

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9 December 2017

Fang He

6

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Europe PubMed Central

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9 December 2017

Ciliu Zhang

7

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9 December 2017

Qiulian Xiang

8

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Europe PubMed Central

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9 December 2017

Huimin Kong

9

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Europe PubMed Central

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9 December 2017

Yupin Ma

10

1 reference

Europe PubMed Central

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9 December 2017

Muhammad Usman Ashhab

11

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9 December 2017

Xiaolu Deng

12

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9 December 2017

Fei Yin

13

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9 December 2017

publication date

28 August 2013

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9 December 2017

Molecular Neurobiology

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9 December 2017

49

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Europe PubMed Central

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9 December 2017

1

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Europe PubMed Central

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9 December 2017

337-351

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Europe PubMed Central

PubMed publication ID

9 December 2017

New roles for interleukin-1 Beta in the mechanisms of epilepsy

1 reference

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Interleukin-1beta immunoreactivity and microglia are enhanced in the rat hippocampus by focal kainate application: functional evidence for enhancement of electrographic seizures

1 reference

https://pubmed.ncbi.nlm.nih.gov/23982744

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Administration of simvastatin after kainic acid-induced status epilepticus restrains chronic temporal lobe epilepsy

1 reference

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Transcriptional upregulation of nitric oxide synthase II by nuclear factor-kappaB promotes apoptotic neuronal cell death in the hippocampus following experimental status epilepticus

1 reference

https://pubmed.ncbi.nlm.nih.gov/23982744

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IL-1β is induced in reactive astrocytes in the somatosensory cortex of rats with genetic absence epilepsy at the onset of spike-and-wave discharges, and contributes to their occurrence.

1 reference

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Reactive astrocytes: cellular and molecular cues to biological function

1 reference

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Dynamics of microglial activation after human traumatic brain injury are revealed by delayed expression of macrophage-related proteins MRP8 and MRP14

1 reference

https://pubmed.ncbi.nlm.nih.gov/23982744

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In vivo targeting of inflammation-associated myeloid-related protein 8/14 via gadolinium immunonanoparticles.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23982744

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Myeloid-related protein-14 contributes to protective immunity in gram-negative pneumonia derived sepsis

1 reference

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Toll-like receptor signaling in neural plasticity and disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/23982744

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Reactions of the immune system in epilepsy

1 reference

https://pubmed.ncbi.nlm.nih.gov/23982744

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Nuclear factor-kappa B regulates seizure threshold and gene transcription following convulsant stimulation

1 reference

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The Toll-like receptor 4 agonist MRP8/14 protein complex is a sensitive indicator for disease activity and predicts relapses in systemic-onset juvenile idiopathic arthritis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23982744

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Activation of Toll-like receptor, RAGE and HMGB1 signalling in malformations of cortical development.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23982744

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Mechanisms of action of antiepileptic drugs: the search for synergy

1 reference

https://pubmed.ncbi.nlm.nih.gov/23982744

12 December 2020

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Febrile Seizures and Mesial Temporal Sclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/23982744

12 December 2020

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Temporal patterns of the cerebral inflammatory response in the rat lithium-pilocarpine model of temporal lobe epilepsy

1 reference

https://pubmed.ncbi.nlm.nih.gov/23982744

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Minocycline- and tetracycline-class antibiotics are protective against partial seizures in vivo.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23982744

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Interleukin-1 signaling in mouse astrocytes involves Akt: a study with interleukin-4 and IL-10

1 reference

https://pubmed.ncbi.nlm.nih.gov/23982744

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Focal seizures due to chronic localized encephalitis

1 reference

https://pubmed.ncbi.nlm.nih.gov/23982744

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The role of inflammation in epilepsy

1 reference

https://pubmed.ncbi.nlm.nih.gov/23982744

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based on heuristic

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Inflammation enhances epileptogenesis in the developing rat brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/23982744

12 December 2020

based on heuristic

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MicroRNA-146a: a key regulator of astrocyte-mediated inflammatory response

1 reference

https://pubmed.ncbi.nlm.nih.gov/23982744

12 December 2020

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A new clinico-pathological classification system for mesial temporal sclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/23982744

12 December 2020

based on heuristic

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Interleukin-1β and microRNA-146a in an immature rat model and children with mesial temporal lobe epilepsy

1 reference

https://pubmed.ncbi.nlm.nih.gov/23982744

12 December 2020

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Prevention of the β-amyloid peptide-induced inflammatory process by inhibition of double-stranded RNA-dependent protein kinase in primary murine mixed co-cultures

1 reference

https://pubmed.ncbi.nlm.nih.gov/23982744

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Epileptogenesis in the immature brain: emerging mechanisms

1 reference

https://pubmed.ncbi.nlm.nih.gov/23982744

12 December 2020

based on heuristic

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Innate immune reaction in response to seizures: implications for the neuropathology associated with epilepsy

1 reference

https://pubmed.ncbi.nlm.nih.gov/23982744

12 December 2020

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The molecular mechanisms of the effect of Dexamethasone and Cyclosporin A on TLR4 /NF-κB signaling pathway activation in oral lichen planus.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23982744

12 December 2020

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Toll-like receptors as targets in chronic liver diseases

1 reference

https://pubmed.ncbi.nlm.nih.gov/23982744

12 December 2020

based on heuristic

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Antiepileptogenic and anticonvulsant activity of interleukin-1 beta in amygdala-kindled rats.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23982744

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Broad expression of Toll-like receptors in the human central nervous system

1 reference

https://pubmed.ncbi.nlm.nih.gov/23982744

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxymatrine reduces neuronal cell apoptosis by inhibiting Toll-like receptor 4/nuclear factor kappa-B-dependent inflammatory responses in traumatic rat brain injury

1 reference

https://pubmed.ncbi.nlm.nih.gov/23982744

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modification of seizure activity by electrical stimulation. II. Motor seizure

1 reference

https://pubmed.ncbi.nlm.nih.gov/23982744

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

TLR signaling pathways

1 reference

https://pubmed.ncbi.nlm.nih.gov/23982744

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Astrocyte TLR4 activation induces a proinflammatory environment through the interplay between MyD88‐dependent NFκB signaling, MAPK, and Jak1/Stat1 pathways

1 reference

https://pubmed.ncbi.nlm.nih.gov/23982744

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

When drugs and surgery don't work

1 reference

https://pubmed.ncbi.nlm.nih.gov/23982744

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Myeloid-related protein 8/14 complex describes microcirculatory alterations in patients with type 2 diabetes and nephropathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/23982744

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Myeloid related proteins activate Toll-like receptor 4 in human acute coronary syndromes

1 reference

https://pubmed.ncbi.nlm.nih.gov/23982744

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

HGF and direct mesenchymal stem cells contact synergize to inhibit hepatic stellate cells activation through TLR4/NF-kB pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/23982744

12 December 2020

based on heuristic

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Powerful anticonvulsant action of IL-1 receptor antagonist on intracerebral injection and astrocytic overexpression in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/23982744

12 December 2020

based on heuristic

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Proinflammatory S100 proteins in arthritis and autoimmune disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/23982744

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

[Pattern recognition receptors]

1 reference

https://pubmed.ncbi.nlm.nih.gov/23982744

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The epidemiology of epilepsy revisited

1 reference

https://pubmed.ncbi.nlm.nih.gov/23982744

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Toll-like receptor 4/nuclear factor-kappa B signaling detected in brain after early subarachnoid hemorrhage.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23982744

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Investigations of hippocampal astrocytes in lipopolysaccharide-preconditioned rats in the pilocarpine model of epilepsy

1 reference

https://pubmed.ncbi.nlm.nih.gov/23982744

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nuclear Factor-Kappa B Activity Regulates Brain Expression of P-Glycoprotein in the Kainic Acid-Induced Seizure Rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/23982744

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The regulatory role of MRP8 (S100A8) and MRP14 (S100A9) in the transendothelial migration of human leukocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/23982744

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nuclear factor-κB binding motifs specify Toll-like receptor-induced gene repression through an inducible repressosome.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23982744

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glia activation and cytokine increase in rat hippocampus by kainic acid-induced status epilepticus during postnatal development

1 reference

https://pubmed.ncbi.nlm.nih.gov/23982744

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Toll signaling pathways in the innate immune response

1 reference

https://pubmed.ncbi.nlm.nih.gov/23982744

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IL-1β induction and IL-6 suppression are associated with aggravated neuronal damage in a lipopolysaccharide-pretreated kainic acid-induced rat pup seizure model

1 reference

https://pubmed.ncbi.nlm.nih.gov/23982744

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cellular injury and neuroinflammation in children with chronic intractable epilepsy

1 reference

https://pubmed.ncbi.nlm.nih.gov/23982744

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inflammatory reactions in human medial temporal lobe epilepsy with hippocampal sclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/23982744

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mrp-8 and -14 mediate CNS injury in focal cerebral ischemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/23982744

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immune-mediated epilepsies.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23982744

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

T cell-microglial dialogue in Parkinson's disease and amyotrophic lateral sclerosis: are we listening?

1 reference

https://pubmed.ncbi.nlm.nih.gov/23982744

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Toll-like receptor 4 and high-mobility group box-1 are involved in ictogenesis and can be targeted to reduce seizures

1 reference

https://pubmed.ncbi.nlm.nih.gov/23982744

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inflammation and prevention of epileptogenesis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23982744

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression patterns of miR-124, miR-134, miR-132, and miR-21 in an immature rat model and children with mesial temporal lobe epilepsy

1 reference

https://pubmed.ncbi.nlm.nih.gov/23982744

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Temporal profiles of age-dependent changes in cytokine mRNA expression and glial cell activation after status epilepticus in postnatal rat hippocampus.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23982744

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased levels of HMGB1 and pro-inflammatory cytokines in children with febrile seizures

1 reference

https://pubmed.ncbi.nlm.nih.gov/23982744

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Innate immunity: the missing link in neuroprotection and neurodegeneration?

1 reference

https://pubmed.ncbi.nlm.nih.gov/23982744

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The IL-1beta system in epilepsy-associated malformations of cortical development

1 reference

https://pubmed.ncbi.nlm.nih.gov/23982744

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of brain inflammation in epileptogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/23982744

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mrp8 and Mrp14 are endogenous activators of Toll-like receptor 4, promoting lethal, endotoxin-induced shock

1 reference

https://pubmed.ncbi.nlm.nih.gov/23982744

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Is epilepsy a progressive disorder? Prospects for new therapeutic approaches in temporal-lobe epilepsy

1 reference

https://pubmed.ncbi.nlm.nih.gov/23982744

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cultured human adult microglia from different donors display stable cytokine, chemokine and growth factor gene profiles but respond differently to a pro-inflammatory stimulus

1 reference

https://pubmed.ncbi.nlm.nih.gov/23982744

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A simplified timm stain procedure compatible with formaldehyde fixation and routine paraffin embedding of rat brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/23982744

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Minocycline attenuates microglia activation and blocks the long-term epileptogenic effects of early-life seizures

1 reference

https://pubmed.ncbi.nlm.nih.gov/23982744

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sequential expression of surface antigens and transcription factor NFkappaB by hippocampal cells in excitotoxicity and experimental epilepsy

1 reference

https://pubmed.ncbi.nlm.nih.gov/23982744

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Myeloid-related proteins 8 and 14 are specifically secreted during interaction of phagocytes and activated endothelium and are useful markers for monitoring disease activity in pauciarticular-onset juvenile rheumatoid arthritis

1 reference

https://pubmed.ncbi.nlm.nih.gov/23982744

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Viral-like brain inflammation during development causes increased seizure susceptibility in adult rats.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23982744

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

New Horizons in the development of antiepileptic drugs: Innovative strategies

1 reference

https://pubmed.ncbi.nlm.nih.gov/23982744

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin-1 and neuronal injury

1 reference

https://pubmed.ncbi.nlm.nih.gov/23982744

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Electroacupuncture exerts anti-inflammatory effects in cerebral ischemia-reperfusion injured rats via suppression of the TLR4/NF-κB pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/23982744

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Astroglial networks and implications for therapeutic neuromodulation of epilepsy

1 reference

https://pubmed.ncbi.nlm.nih.gov/23982744

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phagocyte-specific S100 proteins: a novel group of proinflammatory molecules

1 reference

https://pubmed.ncbi.nlm.nih.gov/23982744

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Innate and adaptive immunity during epileptogenesis and spontaneous seizures: evidence from experimental models and human temporal lobe epilepsy

1 reference

https://pubmed.ncbi.nlm.nih.gov/23982744

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expressions of tumor necrosis factor alpha and microRNA-155 in immature rat model of status epilepticus and children with mesial temporal lobe epilepsy

1 reference

https://pubmed.ncbi.nlm.nih.gov/23982744

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Seizures in children

1 reference

https://pubmed.ncbi.nlm.nih.gov/23982744

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human neuronal cells possess functional cytoplasmic and TLR-mediated innate immune pathways influenced by phosphatidylinositol-3 kinase signaling.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23982744

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Toll-like receptors: critical proteins linking innate and acquired immunity

1 reference

https://pubmed.ncbi.nlm.nih.gov/23982744

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Computational models of neuron-astrocyte interaction in epilepsy

1 reference

https://pubmed.ncbi.nlm.nih.gov/23982744

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Brain inflammation in epilepsy: experimental and clinical evidence

1 reference

https://pubmed.ncbi.nlm.nih.gov/23982744

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

S100 proteins expressed in phagocytes: a novel group of damage-associated molecular pattern molecules

1 reference

https://pubmed.ncbi.nlm.nih.gov/23982744

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antagonism of peripheral inflammation reduces the severity of status epilepticus.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23982744

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Unprovoked seizures in children with febrile seizures: short-term outcome

1 reference

https://pubmed.ncbi.nlm.nih.gov/23982744

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S12035-013-8522-7

1 reference

Europe PubMed Central

PubMed publication ID

9 December 2017

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0 references

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

9 December 2017

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