(Q45050935)

8 December 2017

title

PAR-1 deficiency protects against neuronal damage and neurologic deficits after unilateral cerebral hypoxia/ischemia (English)

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8 December 2017

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Ellen E Olson

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8 December 2017

Polina Lyuboslavsky

series ordinal

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8 December 2017

Stephen F Traynelis

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8 December 2017

Robert J McKeon

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8 December 2017

publication date

1 September 2004

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Journal of Cerebral Blood Flow & Metabolism

8 December 2017

published in

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8 December 2017

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8 December 2017

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8 December 2017

page(s)

964-971

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Thrombin induces in vivo degeneration of nigral dopaminergic neurones along with the activation of microglia.

8 December 2017

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The role of glutamate neurotoxicity in hypoxic-ischemic neuronal death

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Dual effects of thrombin and a 14-amino acid peptide agonist of the thrombin receptor on septal cholinergic neurons

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Blockade of the thrombin receptor protease-activated receptor-1 with a small-molecule antagonist prevents thrombus formation and vascular occlusion in nonhuman primates.

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Serine proteases and brain damage - is there a link?

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Cellular consequences of thrombin-receptor activation

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Thrombin-receptor activation and thrombin-induced brain tolerance

21 January 2018

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The contribution of protease-activated receptor 1 to neuronal damage caused by transient focal cerebral ischemia

21 January 2018

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Reduced cerebral vasomotor reactivity as an indicator of postoperative confusion

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DNA array reveals altered gene expression in response to focal cerebral ischemia

21 January 2018

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Hirudin Suppresses the Invasion of Inflammatory Cells and the Appearance of Vimentin-Positive Astrocytes in the Rat Cerebral Ablation Model

21 January 2018

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Thrombin May Contribute to the Pathophysiology of Central Nervous System Injury

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IGF-I and microglia/macrophage proliferation in the ischemic mouse brain

21 January 2018

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Increase of prothrombin-mRNA after global cerebral ischemia in rats, with constant expression of protease nexin-1 and protease-activated receptors.

21 January 2018

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Common signaling pathways link activation of murine PAR-1, LPA, and S1P receptors to proliferation of astrocytes.

21 January 2018

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Recommendations for standards regarding preclinical neuroprotective and restorative drug development

21 January 2018

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The protease thrombin is an endogenous mediator of hippocampal neuroprotection against ischemia at low concentrations but causes degeneration at high concentrations

21 January 2018

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Excitotoxin-induced neuronal degeneration and seizure are mediated by tissue plasminogen activator.

21 January 2018

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Experimental stroke in the female diabetic, db/db, mouse

21 January 2018

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Thrombin (PAR-1)-induced proliferation in astrocytes via MAPK involves multiple signaling pathways

21 January 2018

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Tissue plasminogen activator (tPA) increase neuronal damage after focal cerebral ischemia in wild-type and tPA-deficient mice

21 January 2018

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The role of thrombin and thrombin receptors in ischemic, hemorrhagic and traumatic brain injury: deleterious or protective?

21 January 2018

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10.1097/01.WCB.0000128266.87474.BF

21 January 2018

Identifiers

DOI

1 reference

Dimensions Publication ID

8 December 2017

1043105588

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1 reference