(Q44973640)

7 December 2017

title

CD4 enhances T cell sensitivity to antigen by coordinating Lck accumulation at the immunological synapse (English)

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7 December 2017

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Qi-Jing Li

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7 December 2017

Aaron R Dinner

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7 December 2017

Shuyan Qi

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7 December 2017

Darrell J Irvine

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7 December 2017

Johannes B Huppa

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7 December 2017

Mark M Davis

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7 December 2017

Arup K Chakraborty

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7 December 2017

language of work or name

English

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publication date

11 July 2004

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7 December 2017

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7 December 2017

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7 December 2017

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7 December 2017

page(s)

791-799

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Dynamics of Cell Surface Molecules During T Cell Recognition

7 December 2017

cites work

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Direct observation of ligand recognition by T cells.

21 January 2018

1 reference

Role of CD4 and CD8 in T cell activation and differentiation

21 January 2018

1 reference

How the immune system works to protect the host from infection: a personal view

21 January 2018

1 reference

Self-recognition promotes the foreign antigen sensitivity of naive T lymphocytes

21 January 2018

1 reference

Differential requirements for survival and proliferation of CD8 naïve or memory T cells

21 January 2018

1 reference

Interaction between CD4 and class II MHC molecules mediates cell adhesion

21 January 2018

1 reference

Signal transduction through the CD4 receptor involves the activation of the internal membrane tyrosine-protein kinase p56lck

21 January 2018

1 reference

The CD4 and CD8 T cell surface antigens are associated with the internal membrane tyrosine-protein kinase p56lck

21 January 2018

1 reference

CD4 dimers constitute the functional component required for T cell activation

21 January 2018

1 reference

An amplified sensitivity arising from covalent modification in biological systems

21 January 2018

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Sensitivity amplification in biochemical systems

21 January 2018

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Fluctuations and quality of control in biological cells: zero-order ultrasensitivity reinvestigated

21 January 2018

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A kinase-independent function of Lck in potentiating antigen-specific T cell activation

21 January 2018

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Regulation of Lck activity by CD4 and CD28 in the immunological synapse

21 January 2018

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Dynamics of p56lck translocation to the T cell immunological synapse following agonist and antagonist stimulation

21 January 2018

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Linking molecular and cellular events in T-cell activation and synapse formation

21 January 2018

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Paradoxical intrathymic positive selection in mice with only a covalently presented agonist peptide

21 January 2018

1 reference

Crystal structure of the human CD4 N-terminal two-domain fragment complexed to a class II MHC molecule

21 January 2018

1 reference

Dimeric association and segmental variability in the structure of human CD4

21 January 2018

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Oligomerization of CD4 is required for stable binding to class II major histocompatibility complex proteins but not for interaction with human immunodeficiency virus gp120

21 January 2018

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Direct evidence for native CD4 oligomers in lymphoid and monocytoid cells

21 January 2018

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Involvement of both major histocompatibility complex class II alpha and beta chains in CD4 function indicates a role for ordered oligomerization in T cell activation

21 January 2018

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The immunological synapse balances T cell receptor signaling and degradation

21 January 2018

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Exact stochastic simulation of coupled chemical reactions

21 January 2018

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Evidence that structural rearrangements and/or flexibility during TCR binding can contribute to T cell activation

21 January 2018

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The immunological synapse: a molecular machine controlling T cell activation

21 January 2018

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Correlations between T-cell specificity and the structure of the antigen receptor

21 January 2018

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T-cell activation: the power of one.

21 January 2018

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Serial triggering of many T-cell receptors by a few peptide-MHC complexes

21 January 2018

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Kinetic proofreading in T-cell receptor signal transduction

21 January 2018

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Kinetic discrimination in T-cell activation

21 January 2018

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CD8(-) T cell transfectants that express a high affinity T cell receptor exhibit enhanced peptide-dependent activation.

21 January 2018

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Amino acid substitutions in the putative MHC class II "dimer of dimers" interface inhibit CD4+ T cell activation

21 January 2018

1 reference

The structure of MHC class II: a role for dimer of dimers

21 January 2018

1 reference

Detection of dimers of dimers of human leukocyte antigen (HLA)-DR on the surface of living cells by single-particle fluorescence imaging

21 January 2018

1 reference

T Cell Receptor Binding to a pMHCII Ligand Is Kinetically Distinct from and Independent of CD4.

21 January 2018

1 reference

Interactions of CD4 with MHC class II molecules, T cell receptors and p56lck

21 January 2018

1 reference

Molecular interactions, T-cell subsets and a role of the CD4/CD8:p56lck complex in human T-cell activation

21 January 2018

1 reference

The T cell receptor as a multicomponent signalling machine: CD4/CD8 coreceptors and CD45 in T cell activation

21 January 2018

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A model for receptor-regulated calcium entry

21 January 2018

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Erratum: Costimulation and endogenous MHC ligands contribute to T cell recognition

21 January 2018

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Selecting and maintaining a diverse T-cell repertoire

21 January 2018

1 reference

7 January 2021

CD4 dimerization and oligomerization: implications for T-cell function and structure-based drug design

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7 January 2021

Activated TCRs remain marked for internalization after dissociation from pMHC

1 reference

7 January 2021

Quantitative analysis of the contribution of TCR/pepMHC affinity and CD8 to T cell activation

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7 January 2021

Identifiers

DOI

10.1038/NI1095

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7 December 2017

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