(Q44714283)

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A chemical genetic screen identifies inhibitors of regulated nuclear export of a Forkhead transcription factor in PTEN-deficient tumor cells

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Europe PubMed Central

PubMed publication ID

5 December 2017

A chemical genetic screen identifies inhibitors of regulated nuclear export of a Forkhead transcription factor in PTEN-deficient tumor cells (English)

1 reference

Europe PubMed Central

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5 December 2017

Frank C Schroeder

2

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Europe PubMed Central

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5 December 2017

9

object named as

Pamela A Silver

1 reference

Europe PubMed Central

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5 December 2017

7

object named as

Jon Clardy

1 reference

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5 December 2017

author name string

Tweeny R Kau

1

1 reference

Europe PubMed Central

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5 December 2017

Shivapriya Ramaswamy

3

1 reference

Europe PubMed Central

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5 December 2017

Cheryl L Wojciechowski

4

1 reference

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5 December 2017

Jean J Zhao

5

1 reference

Europe PubMed Central

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5 December 2017

Thomas M Roberts

6

1 reference

Europe PubMed Central

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5 December 2017

William R Sellers

8

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5 December 2017

publication date

1 December 2003

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5 December 2017

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Europe PubMed Central

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5 December 2017

4

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Europe PubMed Central

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5 December 2017

6

1 reference

Europe PubMed Central

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5 December 2017

463-476

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Europe PubMed Central

PubMed publication ID

5 December 2017

A role for Hsc70 in regulating nucleocytoplasmic transport of a temperature-sensitive p53 (p53Val-135)

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900303-9

7 January 2021

based on heuristic

inferred from DOI database lookup

Protein kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900303-9

7 January 2021

based on heuristic

inferred from DOI database lookup

Dopamine induces a PI3-kinase-independent activation of Akt in striatal neurons: a new route to cAMP response element-binding protein phosphorylation.

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900303-9

7 January 2021

based on heuristic

inferred from DOI database lookup

Inhibition of nuclear import by protein kinase B (Akt) regulates the subcellular distribution and activity of the forkhead transcription factor AFX.

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900303-9

7 January 2021

based on heuristic

inferred from DOI database lookup

Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900303-9

7 January 2021

based on heuristic

inferred from DOI database lookup

Protein kinase SGK mediates survival signals by phosphorylating the forkhead transcription factor FKHRL1 (FOXO3a)

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900303-9

7 January 2021

based on heuristic

inferred from DOI database lookup

14-3-3 transits to the nucleus and participates in dynamic nucleocytoplasmic transport

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900303-9

7 January 2021

based on heuristic

inferred from DOI database lookup

Calmodulin mediates brain-derived neurotrophic factor cell survival signaling upstream of Akt kinase in embryonic neocortical neurons

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900303-9

7 January 2021

based on heuristic

inferred from DOI database lookup

Regulation of the forkhead transcription factor FKHR, but not the PAX3-FKHR fusion protein, by the serine/threonine kinase Akt.

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900303-9

7 January 2021

based on heuristic

inferred from DOI database lookup

Dual actions of (-)-stepholidine on the dopamine receptor-mediated adenylate cyclase activity in rat corpus striatum

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900303-9

7 January 2021

based on heuristic

inferred from DOI database lookup

Neuronal survival induced by neurotrophins requires calmodulin

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900303-9

7 January 2021

based on heuristic

inferred from DOI database lookup

CRM1 is an export receptor for leucine-rich nuclear export signals

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900303-9

7 January 2021

based on heuristic

inferred from DOI database lookup

CRM1 is responsible for intracellular transport mediated by the nuclear export signal

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900303-9

7 January 2021

based on heuristic

inferred from DOI database lookup

Nuclear export signals and the fast track to the cytoplasm

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900303-9

7 January 2021

based on heuristic

inferred from DOI database lookup

A simplified system for generating recombinant adenoviruses

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900303-9

7 January 2021

based on heuristic

inferred from DOI database lookup

A comparison of the activity, sequence specificity, and CRM1-dependence of different nuclear export signals

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900303-9

7 January 2021

based on heuristic

inferred from DOI database lookup

Activation of p53 in cervical carcinoma cells by small molecules.

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900303-9

7 January 2021

based on heuristic

inferred from DOI database lookup

Increased intracellular calcium activates serum and glucocorticoid-inducible kinase 1 (SGK1) through a calmodulin-calcium calmodulin dependent kinase kinase pathway in Chinese hamster ovary cells

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900303-9

7 January 2021

based on heuristic

inferred from DOI database lookup

Nuclear transport as a target for cell growth

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900303-9

7 January 2021

based on heuristic

inferred from DOI database lookup

Protective effect of dopamine D2 agonists in cortical neurons via the phosphatidylinositol 3 kinase cascade.

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900303-9

7 January 2021

based on heuristic

inferred from DOI database lookup

PTEN/MMAC1/TEP1 mutations in human primary renal-cell carcinomas and renal carcinoma cell lines

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900303-9

7 January 2021

based on heuristic

inferred from DOI database lookup

PTEN1 is frequently mutated in primary endometrial carcinomas

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900303-9

7 January 2021

based on heuristic

inferred from DOI database lookup

Direct control of the Forkhead transcription factor AFX by protein kinase B

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900303-9

7 January 2021

based on heuristic

inferred from DOI database lookup

Leptomycin B inhibition of signal-mediated nuclear export by direct binding to CRM1

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900303-9

7 January 2021

based on heuristic

inferred from DOI database lookup

Leptomycin B inactivates CRM1/exportin 1 by covalent modification at a cysteine residue in the central conserved region

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900303-9

7 January 2021

based on heuristic

inferred from DOI database lookup

An inhibitor of nuclear export activates the p53 response and induces the localization of HDM2 and p53 to U1A-positive nuclear bodies associated with the PODs

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900303-9

7 January 2021

based on heuristic

inferred from DOI database lookup

Accumulating active p53 in the nucleus by inhibition of nuclear export: a novel strategy to promote the p53 tumor suppressor function

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900303-9

7 January 2021

based on heuristic

inferred from DOI database lookup

The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900303-9

7 January 2021

based on heuristic

inferred from DOI database lookup

Estrogen regulation of Pak1 and FKHR pathways in breast cancer cells

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900303-9

7 January 2021

based on heuristic

inferred from DOI database lookup

AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900303-9

7 January 2021

based on heuristic

inferred from DOI database lookup

Role of ERK and calcium in the hypoxia-induced activation of HIF-1.

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900303-9

7 January 2021

based on heuristic

inferred from DOI database lookup

Forkhead transcription factors are critical effectors of cell death and cell cycle arrest downstream of PTEN.

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900303-9

7 January 2021

based on heuristic

inferred from DOI database lookup

The NES-Crm1p export pathway is not a major mRNA export route in Saccharomyces cerevisiae

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900303-9

7 January 2021

based on heuristic

inferred from DOI database lookup

Phase I trial of elactocin

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900303-9

7 January 2021

based on heuristic

inferred from DOI database lookup

Evidence for a role of CRM1 in signal-mediated nuclear protein export

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900303-9

7 January 2021

based on heuristic

inferred from DOI database lookup

Regulation of G1 progression by the PTEN tumor suppressor protein is linked to inhibition of the phosphatidylinositol 3-kinase/Akt pathway

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900303-9

7 January 2021

based on heuristic

inferred from DOI database lookup

Phosphorylation of the transcription factor forkhead family member FKHR by protein kinase B

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900303-9

7 January 2021

based on heuristic

inferred from DOI database lookup

Roles of the forkhead in rhabdomyosarcoma (FKHR) phosphorylation sites in regulating 14-3-3 binding, transactivation and nuclear targetting

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900303-9

7 January 2021

based on heuristic

inferred from DOI database lookup

Two novel phosphorylation sites on FKHR that are critical for its nuclear exclusion

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900303-9

7 January 2021

based on heuristic

inferred from DOI database lookup

Exportin 1 (Crm1p) is an essential nuclear export factor

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900303-9

7 January 2021

based on heuristic

inferred from DOI database lookup

PI3-kinase inhibition: a target for drug development?

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900303-9

7 January 2021

based on heuristic

inferred from DOI database lookup

Regulation of nuclear translocation of forkhead transcription factor AFX by protein kinase B

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900303-9

7 January 2021

based on heuristic

inferred from DOI database lookup

Negative regulation of the forkhead transcription factor FKHR by Akt.

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900303-9

7 January 2021

based on heuristic

inferred from DOI database lookup

A member of the Ran-binding protein family, Yrb2p, is involved in nuclear protein export

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900303-9

7 January 2021

based on heuristic

inferred from DOI database lookup

Effects of recent and reference antipsychotic agents at human dopamine D2 and D3 receptor signaling in Chinese hamster ovary cells

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900303-9

7 January 2021

based on heuristic

inferred from DOI database lookup

Inhibition of human breast cancer colony formation by anticalmodulin agents: trifluoperazine, W-7, and W-13

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900303-9

7 January 2021

based on heuristic

inferred from DOI database lookup

Leptomycin B is an inhibitor of nuclear export: inhibition of nucleo-cytoplasmic translocation of the human immunodeficiency virus type 1 (HIV-1) Rev protein and Rev-dependent mRNA

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900303-9

7 January 2021

based on heuristic

inferred from DOI database lookup

The kinase DYRK1A phosphorylates the transcription factor FKHR at Ser329 in vitro, a novel in vivo phosphorylation site

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900303-9

7 January 2021

based on heuristic

inferred from DOI database lookup

A comparison of demethoxyviridin and wortmannin as inhibitors of phosphatidylinositol 3-kinase.

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900303-9

7 January 2021

based on heuristic

inferred from DOI database lookup

Calcium promotes cell survival through CaM-K kinase activation of the protein-kinase-B pathway

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900303-9

7 January 2021

based on heuristic

inferred from DOI database lookup

Human mammary epithelial cell transformation through the activation of phosphatidylinositol 3-kinase

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1016/S1535-6108(03)00303-9

1 reference

Europe PubMed Central

PubMed publication ID

5 December 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

5 December 2017

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