(Q44775125)

6 December 2017

title

FLT3 receptors with internal tandem duplications promote cell viability and proliferation by signaling through Foxo proteins (English)

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6 December 2017

Blanca Scheijen

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6 December 2017

Hai T Ngo

series ordinal

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6 December 2017

Hyun Kang

series ordinal

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6 December 2017

James D Griffin

series ordinal

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6 December 2017

language of work or name

English

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publication date

1 April 2004

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6 December 2017

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6 December 2017

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6 December 2017

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6 December 2017

page(s)

3338-3349

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Identification of novel FLT-3 Asp835 mutations in adult acute myeloid leukaemia

6 December 2017

cites work

1 reference

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Akt is a direct target of the phosphatidylinositol 3-kinase. Activation by growth factors, v-src and v-Ha-ras, in Sf9 and mammalian cells

21 January 2018

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FKHR-L1 can act as a critical effector of cell death induced by cytokine withdrawal: protein kinase B-enhanced cell survival through maintenance of mitochondrial integrity

21 January 2018

1 reference

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A member of Forkhead transcription factor FKHRL1 is a downstream effector of STI571-induced cell cycle arrest in BCR-ABL-expressing cells

21 January 2018

1 reference

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FOXO proteins regulate tumor necrosis factor-related apoptosis inducing ligand expression. Implications for PTEN mutation in prostate cancer

21 January 2018

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BCR-ABL and interleukin 3 promote haematopoietic cell proliferation and survival through modulation of cyclin D2 and p27Kip1 expression.

21 January 2018

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Phosphorylation of the transcription factor forkhead family member FKHR by protein kinase B

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207456

The forkhead transcription factor FoxO regulates transcription of p27Kip1 and Bim in response to IL-2

21 January 2018

1 reference

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Forkhead family transcription factor FKHRL1 is expressed in human megakaryocytes. Regulation of cell cycling as a downstream molecule of thrombopoietin signaling

21 January 2018

1 reference

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Negative regulation of the forkhead transcription factor FKHR by Akt.

21 January 2018

1 reference

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Essential role of signal transducer and activator of transcription (Stat)5a but not Stat5b for Flt3-dependent signaling

21 January 2018

1 reference

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Forkhead transcription factors contribute to execution of the mitotic programme in mammals

21 January 2018

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7 January 2021

Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity

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7 January 2021

Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

1 reference

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7 January 2021

Regulation of cell death protease caspase-9 by phosphorylation

1 reference

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7 January 2021

Suppression of ovarian follicle activation in mice by the transcription factor Foxo3a

1 reference

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7 January 2021

Interleukin-3-Induced Phosphorylation of BAD Through the Protein Kinase Akt

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7 January 2021

TEL/platelet-derived growth factor receptor beta activates phosphatidylinositol 3 (PI3) kinase and requires PI3 kinase to regulate the cell cycle

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7 January 2021

Expression of the pro-apoptotic Bcl-2 family member Bim is regulated by the forkhead transcription factor FKHR-L1

1 reference

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7 January 2021

Forkhead transcription factor FKHR-L1 modulates cytokine-dependent transcriptional regulation of p27(KIP1).

1 reference

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7 January 2021

The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase

1 reference

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7 January 2021

The roles of FLT3 in hematopoiesis and leukemia

1 reference

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7 January 2021

Tandem-duplicated Flt3 constitutively activates STAT5 and MAP kinase and introduces autonomous cell growth in IL-3-dependent cell lines

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207456

7 January 2021

FLT3 internal tandem duplication mutations associated with human acute myeloid leukemias induce myeloproliferative disease in a murine bone marrow transplant model

1 reference

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7 January 2021

Direct control of the Forkhead transcription factor AFX by protein kinase B

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207456

7 January 2021

A FLT3-targeted tyrosine kinase inhibitor is cytotoxic to leukemia cells in vitro and in vivo

1 reference

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7 January 2021

Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207456

7 January 2021

AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207456

7 January 2021

Different antiapoptotic pathways between wild-type and mutated FLT3: insights into therapeutic targets in leukemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207456

7 January 2021

Insulin regulation of gene expression through the forkhead transcription factor Foxo1 (Fkhr) requires kinases distinct from Akt.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207456

7 January 2021

The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207456

7 January 2021

Tyrosine kinase oncogenes in normal hematopoiesis and hematological disease

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207456

7 January 2021

A new and recurrent activating length mutation in exon 20 of the FLT3 gene in acute myeloid leukemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207456

7 January 2021

Analysis of FLT3-activating mutations in 979 patients with acute myelogenous leukemia: association with FAB subtypes and identification of subgroups with poor prognosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207456

7 January 2021

p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207456

7 January 2021

Activation of the Akt/FKHRL1 pathway mediates the antiapoptotic effects of erythropoietin in primary human erythroid progenitors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207456

7 January 2021

Essential role for the BH3-only protein Bim but redundant roles for Bax, Bcl-2, and Bcl-w in the control of granulocyte survival

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207456

7 January 2021

Inhibition of mutant FLT3 receptors in leukemia cells by the small molecule tyrosine kinase inhibitor PKC412.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207456

7 January 2021

Dominant-negative c-Jun promotes neuronal survival by reducing BIM expression and inhibiting mitochondrial cytochrome c release

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207456

7 January 2021

BRCA1 transactivates the cyclin-dependent kinase inhibitor p27(Kip1)

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207456

7 January 2021

Repression of transcription of the p27(Kip1) cyclin-dependent kinase inhibitor gene by c-Myc.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207456

7 January 2021

In vivo treatment of mutant FLT3-transformed murine leukemia with a tyrosine kinase inhibitor

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207456

7 January 2021

Targeted inhibition of FLT3 overcomes the block to myeloid differentiation in 32Dcl3 cells caused by expression of FLT3/ITD mutations

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207456

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1207456

1 reference

6 December 2017

1 reference