(Q44635536)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14583619%20AND%20SRC:MED&resulttype=core&format=json

20 December 2019

title

Substitution in position 3 of cyclosporin A abolishes the cyclophilin-mediated gain-of-function mechanism but not immunosuppression (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14583619%20AND%20SRC:MED&resulttype=core&format=json

20 December 2019

1 reference

1 reference

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14583619%20AND%20SRC:MED&resulttype=core&format=json

20 December 2019

Andreas Radbruch

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14583619%20AND%20SRC:MED&resulttype=core&format=json

20 December 2019

Yixin Zhang

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14583619%20AND%20SRC:MED&resulttype=core&format=json

20 December 2019

Frank Erdmann

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14583619%20AND%20SRC:MED&resulttype=core&format=json

20 December 2019

Andreas Thiel

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14583619%20AND%20SRC:MED&resulttype=core&format=json

20 December 2019

Matthias Weiwad

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14583619%20AND%20SRC:MED&resulttype=core&format=json

20 December 2019

Gunter Fischer

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14583619%20AND%20SRC:MED&resulttype=core&format=json

20 December 2019

language of work or name

English

0 references

publication date

28 October 2003

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14583619%20AND%20SRC:MED&resulttype=core&format=json

Journal of Biological Chemistry

20 December 2019

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14583619%20AND%20SRC:MED&resulttype=core&format=json

20 December 2019

volume

279

1 reference

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20 December 2019

issue

1 reference

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20 December 2019

page(s)

2470-2479

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14583619%20AND%20SRC:MED&resulttype=core&format=json

Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes

20 December 2019

cites work

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304754200

The mechanism of action of cyclosporin A and FK506

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304754200

X-ray structure of calcineurin inhibited by the immunophilin-immunosuppressant FKBP12-FK506 complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304754200

Crystal structures of human calcineurin and the human FKBP12-FK506-calcineurin complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304754200

Crystal structure of calcineurin-cyclophilin-cyclosporin shows common but distinct recognition of immunophilin-drug complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304754200

Crystal structure of human calcineurin complexed with cyclosporin A and human cyclophilin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304754200

Is cyclophilin involved in the immunosuppressive and nephrotoxic mechanism of action of cyclosporin A?

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304754200

Concerted dephosphorylation of the transcription factor NFAT1 induces a conformational switch that regulates transcriptional activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304754200

Defective T cell development and function in calcineurin A beta -deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304754200

T cell responses in calcineurin A alpha-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304754200

Chemical genetics resulting from a passion for synthetic organic chemistry

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304754200

The 3D structure of a cyclosporin analogue in water is nearly identical to the cyclophilin-bound cyclosporin conformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304754200

Good fungi gone bad: the corruption of calcineurin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304754200

Calcineurin. Structure, function, and inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304754200

All cyclophilins and FK506 binding proteins are, individually and collectively, dispensable for viability in Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304754200

Overexpression and purification of human calcineurin alpha from Escherichia coli and assessment of catalytic functions of residues surrounding the binuclear metal center.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304754200

Comparative mutational analysis of peptidyl prolyl cis/trans isomerases: active sites of Escherichia coli trigger factor and human FKBP12.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304754200

Reversible inhibition of calcineurin by the polyphenolic aldehyde gossypol.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304754200

Cyclophilin and peptidyl-prolyl cis-trans isomerase are probably identical proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304754200

Induction by antigen of intrathymic apoptosis of CD4+CD8+TCRlo thymocytes in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304754200

Instruction for cytokine expression in T helper lymphocytes in relation to proliferation and cell cycle progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304754200

Calcineurin is essential in cyclosporin A- and FK506-sensitive yeast strains

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304754200

A functional chaperone triad on the yeast ribosome

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304754200

Cyclosporin-mediated inhibition of bovine calcineurin by cyclophilins A and B

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304754200

Molecular mechanisms of the protein serine/threonine phosphatases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304754200

Antigen-specific cytometry

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304754200

Sanglifehrin A, a novel cyclophilin-binding compound showing immunosuppressive activity with a new mechanism of action

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304754200

Affinity-driven peptide selection of an NFAT inhibitor more selective than cyclosporin A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304754200

X-ray structure of a monomeric cyclophilin A-cyclosporin A crystal complex at 2.1 A resolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304754200

Analysis of the kinetics of reversible enzyme inhibition by a general algebraic method. Application to multisite inhibition of the phosphoglycerate kinase from Trypanosoma brucei.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304754200

Evidence that calcineurin is rate-limiting for primary human lymphocyte activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304754200

Calcineurin binds the transcription factor NFAT1 and reversibly regulates its activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304754200

Transcription factors of the NFAT family: regulation and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304754200

Nucleocytoplasmic shuttling and the control of NF-AT signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304754200

Two distinct signal transmission pathways in T lymphocytes are inhibited by complexes formed between an immunophilin and either FK506 or rapamycin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304754200

High gradient magnetic cell separation with MACS

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304754200

21 January 2018

Identifiers

DOI

10.1074/JBC.M304754200

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14583619%20AND%20SRC:MED&resulttype=core&format=json

20 December 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14583619%20AND%20SRC:MED&resulttype=core&format=json