(Q44405189)

2 December 2017

title

Partial purification and characterization of gamma-secretase from post-mortem human brain (English)

1 reference

2 December 2017

Partial Purification and Characterization of γ-Secretase from Post-mortem Human Brain (English)

1 reference

https://api.crossref.org/works/10.1074/JBC.M211992200

24 December 2023

1 reference

https://api.crossref.org/works/10.1074/JBC.M211992200

24 December 2023

1 reference

https://api.crossref.org/works/10.1074/JBC.M211992200

24 December 2023

Bengt Winblad

1 reference

2 December 2017

Anna Bergman

1 reference

2 December 2017

Jan Näslund

1 reference

2 December 2017

Mark R. Farmery

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12697771

24 December 2023

Lars O. Tjernberg

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12697771

24 December 2023

Sharon E. Pursglove

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12697771

24 December 2023

language of work or name

English

0 references

publication date

15 April 2003

1 reference

full work available at URL

2 December 2017

http://www.jbc.org/content/278/27/24277.full.pdf

file format

Portable Document Format

online access status

open access

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12697771

https://api.elsevier.com/content/article/PII:S0021925820868781?httpAccept=text/xml

24 December 2023

1 reference

https://api.crossref.org/works/10.1074/JBC.M211992200

https://api.elsevier.com/content/article/PII:S0021925820868781?httpAccept=text/plain

24 December 2023

1 reference

https://api.crossref.org/works/10.1074/JBC.M211992200

https://syndication.highwire.org/content/doi/10.1074/jbc.M211992200

24 December 2023

1 reference

https://api.crossref.org/works/10.1074/JBC.M211992200

Journal of Biological Chemistry

24 December 2023

published in

1 reference

2 December 2017

volume

278

1 reference

2 December 2017

1 reference

2 December 2017

page(s)

24277-24284

1 reference

Presenilin, Notch, and the genesis and treatment of Alzheimer's disease

2 December 2017

cites work

1 reference

https://api.crossref.org/works/10.1074/JBC.M211992200

Visualization of A beta 42(43) and A beta 40 in senile plaques with end-specific A beta monoclonals: evidence that an initially deposited species is A beta 42(43).

24 December 2023

1 reference

https://api.crossref.org/works/10.1074/JBC.M211992200

Correlation between elevated levels of amyloid beta-peptide in the brain and cognitive decline

24 December 2023

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https://api.crossref.org/works/10.1074/JBC.M211992200

Alzheimer disease therapy: can the amyloid cascade be halted?

24 December 2023

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Intramembrane proteolysis by presenilins

24 December 2023

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Genotype and phenotype in Alzheimer's disease

24 December 2023

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https://api.crossref.org/works/10.1074/JBC.M211992200

Alzheimer's disease: genes, proteins, and therapy

24 December 2023

1 reference

https://api.crossref.org/works/10.1074/JBC.M211992200

Presenilins are required for gamma-secretase cleavage of beta-APP and transmembrane cleavage of Notch-1

24 December 2023

1 reference

https://api.crossref.org/works/10.1074/JBC.M211992200

Peptidomimetic probes and molecular modeling suggest that Alzheimer's gamma-secretase is an intramembrane-cleaving aspartyl protease

24 December 2023

1 reference

https://api.crossref.org/works/10.1074/JBC.M211992200

Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1.

24 December 2023

1 reference

https://api.crossref.org/works/10.1074/JBC.M211992200

Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1

24 December 2023

1 reference

https://api.crossref.org/works/10.1074/JBC.M211992200

Positive-negative epitope-tagging of beta amyloid precursor protein to identify inhibitors of A beta processing.

24 December 2023

1 reference

https://api.crossref.org/works/10.1074/JBC.M211992200

L-685,458, an aspartyl protease transition state mimic, is a potent inhibitor of amyloid beta-protein precursor gamma-secretase activity

24 December 2023

1 reference

https://api.crossref.org/works/10.1074/JBC.M211992200

The presenilins in Alzheimer's disease--proteolysis holds the key.

24 December 2023

1 reference

https://api.crossref.org/works/10.1074/JBC.M211992200

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

24 December 2023

1 reference

https://api.crossref.org/works/10.1074/JBC.M211992200

Effects of PS1 deficiency on membrane protein trafficking in neurons

24 December 2023

1 reference

https://api.crossref.org/works/10.1074/JBC.M211992200

Regulated intramembrane proteolysis: a control mechanism conserved from bacteria to humans

24 December 2023

1 reference

https://api.crossref.org/works/10.1074/JBC.M211992200

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

24 December 2023

1 reference

https://api.crossref.org/works/10.1074/JBC.M211992200

gamma -Secretase cleavage and nuclear localization of ErbB-4 receptor tyrosine kinase

24 December 2023

1 reference

https://api.crossref.org/works/10.1074/JBC.M211992200

A presenilin-1/gamma-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctions

24 December 2023

1 reference

https://api.crossref.org/works/10.1074/JBC.M211992200

The Proteolytic Fragments of the Alzheimer's Disease-associated Presenilin-1 Form Heterodimers and Occur as a 100–150-kDa Molecular Mass Complex

24 December 2023

1 reference

https://api.crossref.org/works/10.1074/JBC.M211992200

The presenilin 1 protein is a component of a high molecular weight intracellular complex that contains beta-catenin

24 December 2023

1 reference

https://api.crossref.org/works/10.1074/JBC.M211992200

Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state

24 December 2023

1 reference

https://api.crossref.org/works/10.1074/JBC.M211992200

Activity-dependent isolation of the presenilin- gamma -secretase complex reveals nicastrin and a gamma substrate

24 December 2023

1 reference

https://api.crossref.org/works/10.1074/JBC.M211992200

Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing

24 December 2023

1 reference

https://api.crossref.org/works/10.1074/JBC.M211992200

Nicastrin is required for Presenilin-mediated transmembrane cleavage in Drosophila

24 December 2023

1 reference

https://api.crossref.org/works/10.1074/JBC.M211992200

Nicastrin is required for gamma-secretase cleavage of the Drosophila Notch receptor

24 December 2023

1 reference

https://api.crossref.org/works/10.1074/JBC.M211992200

Gamma-secretase activity is associated with a conformational change of nicastrin

24 December 2023

1 reference

https://api.crossref.org/works/10.1074/JBC.M211992200

aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation

24 December 2023

1 reference

https://api.crossref.org/works/10.1074/JBC.M211992200

APH-1 is a multipass membrane protein essential for the Notch signaling pathway in Caenorhabditis elegans embryos

24 December 2023

1 reference

https://api.crossref.org/works/10.1074/JBC.M211992200

PEN-2 is an integral component of the gamma-secretase complex required for coordinated expression of presenilin and nicastrin

24 December 2023

1 reference

https://api.crossref.org/works/10.1074/JBC.M211992200

Mammalian APH-1 interacts with presenilin and nicastrin and is required for intramembrane proteolysis of amyloid-beta precursor protein and Notch

24 December 2023

1 reference

https://api.crossref.org/works/10.1074/JBC.M211992200

PEN-2 and APH-1 coordinately regulate proteolytic processing of presenilin 1.

24 December 2023

1 reference

https://api.crossref.org/works/10.1074/JBC.M211992200

The role of presenilin cofactors in the gamma-secretase complex

24 December 2023

1 reference

https://api.crossref.org/works/10.1074/JBC.M211992200

Reconstitution of gamma-secretase activity

24 December 2023

1 reference

https://api.crossref.org/works/10.1074/JBC.M211992200

Cell-free assays for gamma-secretase activity

24 December 2023

1 reference

https://api.crossref.org/works/10.1074/JBC.M211992200

APH-2/nicastrin functions in LIN-12/Notch signaling in the Caenorhabditis elegans somatic gonad.

24 December 2023

1 reference

https://api.crossref.org/works/10.1074/JBC.M211992200

Enzyme activity of human central nervous system myelin

24 December 2023

1 reference

https://api.crossref.org/works/10.1074/JBC.M211992200

Evidence for a mitochondrial oxidative phosphorylation defect in brains from patients with schizophrenia

24 December 2023

1 reference

https://api.crossref.org/works/10.1074/JBC.M211992200

Mice lacking both presenilin genes exhibit early embryonic patterning defects

24 December 2023

1 reference

https://api.crossref.org/works/10.1074/JBC.M211992200

Oligomeric and conformational properties of a proteolytically mature, disulfide-stabilized human immunodeficiency virus type 1 gp140 envelope glycoprotein

24 December 2023

1 reference

https://api.crossref.org/works/10.1074/JBC.M211992200

High throughput two-dimensional blue-native electrophoresis: a tool for functional proteomics of mitochondria and signaling complexes

24 December 2023

1 reference

https://api.crossref.org/works/10.1074/JBC.M211992200

Notch receptor cleavage depends on but is not directly executed by presenilins

24 December 2023

1 reference

https://api.crossref.org/works/10.1074/JBC.M211992200

Pepstatin, a new pepsin inhibitor produced by Actinomycetes

24 December 2023

1 reference

https://api.crossref.org/works/10.1074/JBC.M211992200

Aspartyl protease inhibitor pepstatin binds to the presenilins of Alzheimer's disease.

24 December 2023

1 reference

https://api.crossref.org/works/10.1074/JBC.M211992200

Generation of C-terminally truncated amyloid-beta peptides is dependent on gamma-secretase activity.

24 December 2023

1 reference

https://api.crossref.org/works/10.1074/JBC.M211992200

Metabolism of presenilins

24 December 2023

1 reference

https://api.crossref.org/works/10.1074/JBC.M211992200

Presenilin and nicastrin regulate each other and determine amyloid beta-peptide production via complex formation

24 December 2023

1 reference

https://api.crossref.org/works/10.1074/JBC.M211992200

Mature glycosylation and trafficking of nicastrin modulate its binding to presenilins

24 December 2023

1 reference

https://api.crossref.org/works/10.1074/JBC.M211992200

The levels of mature glycosylated nicastrin are regulated and correlate with gamma-secretase processing of amyloid beta-precursor protein

24 December 2023

1 reference

https://api.crossref.org/works/10.1074/JBC.M211992200

Pharmacological knock-down of the presenilin 1 heterodimer by a novel gamma -secretase inhibitor: implications for presenilin biology

24 December 2023

1 reference

https://api.crossref.org/works/10.1074/JBC.M211992200

gamma-Secretase activity requires the presenilin-dependent trafficking of nicastrin through the Golgi apparatus but not its complex glycosylation

24 December 2023

1 reference

https://api.crossref.org/works/10.1074/JBC.M211992200

BACE1 interacts with nicastrin

24 December 2023

1 reference

https://api.crossref.org/works/10.1074/JBC.M211992200

Evidence that the 42- and 40-amino acid forms of amyloid beta protein are generated from the beta-amyloid precursor protein by different protease activities

24 December 2023

1 reference

https://api.crossref.org/works/10.1074/JBC.M211992200

Distinct secretases, a cysteine protease and a serine protease, generate the C termini of amyloid beta-proteins Abeta1-40 and Abeta1-42, respectively

24 December 2023

1 reference

https://api.crossref.org/works/10.1074/JBC.M211992200

Beta-amyloid precursor protein. Location of transmembrane domain and specificity of gamma-secretase cleavage

24 December 2023

1 reference

https://api.crossref.org/works/10.1074/JBC.M211992200

Presenilins are not required for A beta 42 production in the early secretory pathway

24 December 2023

1 reference

https://api.crossref.org/works/10.1074/JBC.M211992200

24 December 2023

Identifiers

1 reference

2 December 2017

1 reference