(Q44170594)

30 November 2017

title

Biochemical evidence for an editing role of thioesterase II in the biosynthesis of the polyketide pikromycin (English)

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30 November 2017

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30 November 2017

Beom Seok Kim

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30 November 2017

T Ashton Cropp

series ordinal

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30 November 2017

Brian J Beck

series ordinal

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30 November 2017

David H Sherman

series ordinal

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30 November 2017

language of work or name

English

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publication date

3 October 2002

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Journal of Biological Chemistry

30 November 2017

published in

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30 November 2017

volume

277

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30 November 2017

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30 November 2017

page(s)

48028-48034

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Genetic Contributions to Understanding Polyketide Synthases

30 November 2017

cites work

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Polyketide synthesis: prospects for hybrid antibiotics

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Modular organization of genes required for complex polyketide biosynthesis

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A gene cluster for macrolide antibiotic biosynthesis in Streptomyces venezuelae: architecture of metabolic diversity

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The biosynthetic gene cluster for the polyketide immunosuppressant rapamycin

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Analysis of five tylosin biosynthetic genes from the tyllBA region of the Streptomyces fradiae genome

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Biosynthesis of the ansamycin antibiotic rifamycin: deductions from the molecular analysis of the rif biosynthetic gene cluster of Amycolatopsis mediterranei S699.

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Cloning and sequence analysis of genes involved in erythromycin biosynthesis in Saccharopolyspora erythraea: sequence similarities between EryG and a family of S-adenosylmethionine-dependent methyltransferases

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Cell-free synthesis of polyketides by recombinant erythromycin polyketide synthases

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Impact of thioesterase activity on tylosin biosynthesis in Streptomyces fradiae.

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The Streptomyces venezuelae pikAV gene contains a transcription unit essential for expression of enzymes involved in glycosylation of narbonolide and 10-deoxymethynolide

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Sequence and analysis of the genetic locus responsible for surfactin synthesis in Bacillus subtilis

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Engineering specificity of starter unit selection by the erythromycin-producing polyketide synthase

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Role of type II thioesterases: evidence for removal of short acyl chains produced by aberrant decarboxylation of chain extender units

21 January 2018

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Expression in Escherichia coli, purification and characterization of two mammalian thioesterases involved in fatty acid synthesis

21 January 2018

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A new enzyme superfamily - the phosphopantetheinyl transferases

21 January 2018

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An unexpected interaction between the modular polyketide synthases, erythromycin DEBS1 and pikromycin PikAIV, leads to efficient triketide lactone synthesis

21 January 2018

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Substrate specificity of the loading didomain of the erythromycin polyketide synthase

21 January 2018

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Cloning of genes governing the deoxysugar portion of the erythromycin biosynthesis pathway in Saccharopolyspora erythraea (Streptomyces erythreus)

21 January 2018

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Mechanisms of molecular recognition in the pikromycin polyketide synthase

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Conversion of a beta-ketoacyl synthase to a malonyl decarboxylase by replacement of the active-site cysteine with glutamine

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Engineered fatty acid biosynthesis in Streptomyces by altered catalytic function of beta-ketoacyl-acyl carrier protein synthase III.

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Spontaneous priming of a downstream module in 6-deoxyerythronolide B synthase leads to polyketide biosynthesis

21 January 2018

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Crystal structure of the macrocycle-forming thioesterase domain of the erythromycin polyketide synthase: Versatility from a unique substrate channel

21 January 2018

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Genome sequence of an industrial microorganism Streptomyces avermitilis: deducing the ability of producing secondary metabolites

21 January 2018

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Process and metabolic strategies for improved production of Escherichia coli-derived 6-deoxyerythronolide B.

21 January 2018

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Generation of multiple bioactive macrolides by hybrid modular polyketide synthases in Streptomyces venezuelae

21 January 2018

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Regeneration of misprimed nonribosomal peptide synthetases by type II thioesterases.

21 January 2018

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Alternative modular polyketide synthase expression controls macrolactone structure

21 January 2018

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Mechanism and specificity of the terminal thioesterase domain from the erythromycin polyketide synthase

21 January 2018

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Genetic evidence for a role of thioesterase domains, integrated in or associated with peptide synthetases, in non-ribosomal peptide biosynthesis in Bacillus subtilis

21 January 2018

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The thioesterase of the erythromycin-producing polyketide synthase: mechanistic studies in vitro to investigate its mode of action and substrate specificity

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M207770200

Thioesterases and the premature termination of polyketide chain elongation in rifamycin B biosynthesis by Amycolatopsis mediterranei S699

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207770200

A chain initiation factor common to both modular and aromatic polyketide synthases

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M207770200

Repositioning of a domain in a modular polyketide synthase to promote specific chain cleavage

21 January 2018

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Heterogeneity of mouse satellite DNA on silver-cesium sulphate density gradient

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.M207770200

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30 November 2017

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