(Q44012083)

28 November 2017

title

The genes for perforin, granzymes A-C and IFN-gamma are differentially expressed in single CD8(+) T cells during primary activation (English)

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28 November 2017

Anne Kelso

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28 November 2017

Elaine O Costelloe

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28 November 2017

Barbara J Johnson

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28 November 2017

Penny Groves

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28 November 2017

Kathy Buttigieg

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28 November 2017

David R Fitzpatrick

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28 November 2017

language of work or name

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1 June 2002

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28 November 2017

published in

International Immunology

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28 November 2017

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28 November 2017

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28 November 2017

page(s)

605-613

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Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice

28 November 2017

cites work

1 reference

https://api.crossref.org/works/10.1093%2FINTIMM%2FDXF028

Immune function in mice lacking the perforin gene

21 January 2018

1 reference

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Granzyme B (GraB) autonomously crosses the cell membrane and perforin initiates apoptosis and GraB nuclear localization.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FINTIMM%2FDXF028

Cytosolic delivery of granzyme B by bacterial toxins: evidence that endosomal disruption, in addition to transmembrane pore formation, is an important function of perforin

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FINTIMM%2FDXF028

Cytotoxic lymphocytes require granzyme B for the rapid induction of DNA fragmentation and apoptosis in allogeneic target cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FINTIMM%2FDXF028

Induction of rapid histone degradation by the cytotoxic T lymphocyte protease Granzyme A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FINTIMM%2FDXF028

Granzyme A initiates an alternative pathway for granule-mediated apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FINTIMM%2FDXF028

Granzyme A is an interleukin 1 beta-converting enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FINTIMM%2FDXF028

Nephritogenic T cells use granzyme C as a cytotoxic mediator

21 January 2018

1 reference

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In Vitro– and Ex Vivo–derived Cytolytic Leukocytes from Granzyme A × B Double Knockout Mice Are Defective in Granule-mediated Apoptosis but not Lysis of Target Cells

21 January 2018

1 reference

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Granzymes are the essential downstream effector molecules for the control of primary virus infections by cytolytic leukocytes

21 January 2018

1 reference

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Granzyme A and B-deficient killer lymphocytes are defective in eliciting DNA fragmentation but retain potent in vivo anti-tumor capacity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FINTIMM%2FDXF028

Granzyme A is critical for recovery of mice from infection with the natural cytopathic viral pathogen, ectromelia

21 January 2018

1 reference

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Regulation of antigen-specific CD8+ T cell homeostasis by perforin and interferon-gamma.

21 January 2018

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Rapid establishment of a stable IL-4/IFN-γ production profile in the antigen-specific CD4+ T cell response to protein immunization

21 January 2018

1 reference

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Distinct methylation of the interferon gamma (IFN-gamma) and interleukin 3 (IL-3) genes in newly activated primary CD8+ T lymphocytes: regional IFN-gamma promoter demethylation and mRNA expression are heritable in CD44(high)CD8+ T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FINTIMM%2FDXF028

A single peripheral CD8+T cell can give rise to progeny expressing type 1 and/or type 2 cytokine genes and can retain its multipotentiality through many cell divisions

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FINTIMM%2FDXF028

FAS is highly expressed in the germinal center but is not required for regulation of the B-cell response to antigen

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FINTIMM%2FDXF028

Co-engagement of CD3 with LFA-1 or ICAM-1 adhesion molecules enhances the frequency of activation of single murine CD4+ and CD8+ T cells and induces synthesis of IL-3 and IFN-gamma but not IL-4 or IL-6.

21 January 2018

1 reference

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A clonal culture system demonstrates that IL-4 induces a subpopulation of noncytolytic T cells with low CD8, perforin, and granzyme expression

21 January 2018

1 reference

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Enumeration of lymphokine mRNA-containing cells in vivo in a murine graft-versus-host reaction using the PCR.

21 January 2018

1 reference

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Evidence for the stochastic acquisition of cytokine profile by CD4+ T cells activated in a T helper type 2-like responsein vivo

21 January 2018

1 reference

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Probing the activation requirements for naive CD8+ T cells with Drosophila cell transfectants as antigen presenting cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FINTIMM%2FDXF028

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FINTIMM%2FDXF028

Organization of the gene encoding the mouse T-cell-specific serine proteinase “granzyme A”

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FINTIMM%2FDXF028

A comparison of the flanking regions of the mouse cytotoxic cell proteinase genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FINTIMM%2FDXF028

Expression of perforin and granzymes in vivo: potential diagnostic markers for activated cytotoxic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FINTIMM%2FDXF028

Long-range disruption of gene expression by a selectable marker cassette

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FINTIMM%2FDXF028

Genomic organization of the mouse pore-forming protein (perforin) gene and localization to chromosome 10. Similarities to and differences from C9.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FINTIMM%2FDXF028

Perforin is activated by a proteolytic cleavage during biosynthesis which reveals a phospholipid-binding C2 domain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FINTIMM%2FDXF028

Dipeptidyl peptidase I is required for the processing and activation of granzymes A and B in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FINTIMM%2FDXF028

Functional diversity of helper T lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FINTIMM%2FDXF028

Cytolytic T-cell cytotoxicity is mediated through perforin and Fas lytic pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FINTIMM%2FDXF028

21 January 2018

Identifiers

DOI

10.1093/INTIMM/DXF028

1 reference

28 November 2017

1 reference