(Q43957787)

28 November 2017

title

A small molecule ubiquitination inhibitor blocks NF-kappa B-dependent cytokine expression in cells and rats (English)

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28 November 2017

main subject

protein ubiquitination

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David C Swinney

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28 November 2017

Yi-Zheng Xu

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28 November 2017

Liliana E Scarafia

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28 November 2017

Ina Lee

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28 November 2017

Amy Y Mak

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28 November 2017

Qing-Fen Gan

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28 November 2017

Chakkodabylu S Ramesha

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28 November 2017

Mary A Mulkins

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28 November 2017

Jim Dunn

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28 November 2017

On-Yee So

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28 November 2017

Teresa Biegel

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28 November 2017

Marie Dinh

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28 November 2017

Pamela Volkel

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28 November 2017

Jim Barnett

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28 November 2017

Stacie A Dalrymple

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28 November 2017

Simon Lee

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28 November 2017

Martin Huber

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28 November 2017

language of work or name

English

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publication date

11 April 2002

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Journal of Biological Chemistry

28 November 2017

published in

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28 November 2017

volume

277

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28 November 2017

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28 November 2017

page(s)

23573-23581

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NF-kappa B: ten years after

28 November 2017

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Defining therapeutic targets by using adenovirus: blocking NF-kappaB inhibits both inflammatory and destructive mechanisms in rheumatoid synovium but spares anti-inflammatory mediators

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NF-kappaB activation provides the potential link between inflammation and hyperplasia in the arthritic joint

21 January 2018

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Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity

21 January 2018

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21 January 2018

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Control of I kappa B-alpha proteolysis by site-specific, signal-induced phosphorylation

21 January 2018

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Mapping of the inducible IkappaB phosphorylation sites that signal its ubiquitination and degradation

21 January 2018

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Critical role for lysines 21 and 22 in signal-induced, ubiquitin-mediated proteolysis of I kappa B-alpha

21 January 2018

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The ubiquitin-proteasome pathway is required for processing the NF-kappa B1 precursor protein and the activation of NF-kappa B

21 January 2018

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Diverse agents act at multiple levels to inhibit the Rel/NF-kappaB signal transduction pathway

21 January 2018

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21 January 2018

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Ubiquitination and deubiquitination: targeting of proteins for degradation by the proteasome

21 January 2018

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Identification of the receptor component of the IkappaBalpha-ubiquitin ligase

21 January 2018

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Signal-induced ubiquitination of IkappaBalpha by the F-box protein Slimb/beta-TrCP

21 January 2018

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SCF(beta-TRCP) and phosphorylation dependent ubiquitinationof I kappa B alpha catalyzed by Ubc3 and Ubc4

21 January 2018

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Site-specific phosphorylation of IkappaBalpha by a novel ubiquitination-dependent protein kinase activity

21 January 2018

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Signal-induced degradation of I kappa B alpha requires site-specific ubiquitination

21 January 2018

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The human F box protein beta-Trcp associates with the Cul1/Skp1 complex and regulates the stability of beta-catenin.

21 January 2018

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The SCFbeta-TRCP-ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in IkappaBalpha and beta-catenin and stimulates IkappaBalpha ubiquitination in vitro

21 January 2018

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Nedd8 modification of cul-1 activates SCF(beta(TrCP))-dependent ubiquitination of IkappaBalpha

21 January 2018

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Selective small molecule inhibitors of glycogen synthase kinase-3 modulate glycogen metabolism and gene transcription

21 January 2018

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Some antioxidants inhibit, in a co-ordinate fashion, the production of tumor necrosis factor-alpha, IL-beta, and IL-6 by human peripheral blood mononuclear cells

21 January 2018

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Stimulation-dependent I kappa B alpha phosphorylation marks the NF-kappa B inhibitor for degradation via the ubiquitin-proteasome pathway

21 January 2018

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Inhibition of NF-kappa-B cellular function via specific targeting of the I-kappa-B-ubiquitin ligase

21 January 2018

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Inducible degradation of IkappaBalpha by the proteasome requires interaction with the F-box protein h-betaTrCP.

21 January 2018

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Tumor necrosis factor receptor-associated factors (TRAFs)--a family of adapter proteins that regulates life and death

21 January 2018

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TAK1 is a ubiquitin-dependent kinase of MKK and IKK

21 January 2018

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The inhibitor of apoptosis, cIAP2, functions as a ubiquitin-protein ligase and promotes in vitro monoubiquitination of caspases 3 and 7

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M200842200

Suppression of tumor necrosis factor-induced cell death by inhibitor of apoptosis c-IAP2 is under NF-kappaB control

21 January 2018

1 reference

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Identification of the ubiquitin carrier proteins, E2s, involved in signal-induced conjugation and subsequent degradation of IkappaBalpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M200842200

21 January 2018

Identifiers

DOI

10.1074/JBC.M200842200

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28 November 2017

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