(Q43823461)

27 November 2017

title

beta-Secretase cleavage of the amyloid precursor protein mediates neuronal apoptosis caused by familial Alzheimer's disease mutations (English)

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27 November 2017

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McPhie DL

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27 November 2017

Golde T

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27 November 2017

Eckman CB

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27 November 2017

Yager D

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27 November 2017

Brant JB

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27 November 2017

Neve RL

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27 November 2017

publication date

1 December 2001

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27 November 2017

published in

Molecular Brain Research

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27 November 2017

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27 November 2017

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27 November 2017

page(s)

103-113

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Increased production of amyloid precursor protein provides a substrate for caspase-3 in dying motoneurons.

27 November 2017

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Overexpression in neurons of human presenilin-1 or a presenilin-1 familial Alzheimer disease mutant does not enhance apoptosis.

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A potential role for apoptosis in neurodegeneration and Alzheimer's disease

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Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-protein production

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Ionic effects of the Alzheimer's disease beta-amyloid precursor protein and its metabolic fragments

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Involvement of caspases in proteolytic cleavage of Alzheimer's amyloid-beta precursor protein and amyloidogenic A beta peptide formation

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Par-4 is a mediator of neuronal degeneration associated with the pathogenesis of Alzheimer disease

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Identification of a Novel Aspartic Protease (Asp 2) as β-Secretase

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Neuronal Expression of β-Amyloid Precursor Protein Alzheimer Mutations Causes Intracellular Accumulation of a C-terminal Fragment Containing Both the Amyloid β and Cytoplasmic Domains

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7 January 2021

Apoptosis and Alzheimer's Disease

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7 January 2021

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7 January 2021

Purification and cloning of amyloid precursor protein beta-secretase from human brain

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7 January 2021

The amyloidogenic pathway of amyloid precursor protein (APP) is independent of its cleavage by caspases

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

G protein-mediated neuronal DNA fragmentation induced by familial Alzheimer's disease-associated mutants of APP.

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7 January 2021

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7 January 2021

Neurotoxicity of a fragment of the amyloid precursor associated with Alzheimer's disease

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7 January 2021

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7 January 2021

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Identifiers

DOI

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27 November 2017

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