(Q43808932)

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Procognitive and antipsychotic efficacy of glycine transport 1 inhibitors (GlyT1) in acute and neurodevelopmental models of schizophrenia: latent inhibition studies in the rat.

scientific article published on 16 August 2008

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Europe PubMed Central

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12 January 2020

Procognitive and antipsychotic efficacy of glycine transport 1 inhibitors (GlyT1) in acute and neurodevelopmental models of schizophrenia: latent inhibition studies in the rat (English)

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12 January 2020

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12 January 2020

4

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12 January 2020

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Mark D Black

1

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12 January 2020

Geoffrey B Varty

2

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12 January 2020

Michal Arad

3

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12 January 2020

Amaya De Levie

5

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12 January 2020

Denis Boulay

6

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12 January 2020

Philippe Pichat

7

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12 January 2020

Ina Weiner

9

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12 January 2020

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16 August 2008

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12 January 2020

Psychopharmacology

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12 January 2020

202

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12 January 2020

1-3

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12 January 2020

385-396

1 reference

Europe PubMed Central

PubMed publication ID

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12 January 2020

Distorted distribution of nicotinamide-adenine dinucleotide phosphate-diaphorase neurons in temporal lobe of schizophrenics implies anomalous cortical development

1 reference

https://api.crossref.org/works/10.1007%2FS00213-008-1289-2

21 January 2018

Maldistribution of interstitial neurons in prefrontal white matter of the brains of schizophrenic patients

1 reference

https://api.crossref.org/works/10.1007%2FS00213-008-1289-2

21 January 2018

Phencyclidine-induced psychosis

1 reference

https://api.crossref.org/works/10.1007%2FS00213-008-1289-2

21 January 2018

Advancing a neurodevelopmental origin for schizophrenia

1 reference

https://api.crossref.org/works/10.1007%2FS00213-008-1289-2

21 January 2018

Recent advances in the neuropathology of schizophrenia

1 reference

https://api.crossref.org/works/10.1007%2FS00213-008-1289-2

21 January 2018

Perseveration in schizophrenia

1 reference

https://api.crossref.org/works/10.1007%2FS00213-008-1289-2

21 January 2018

Functional and Anatomical Aspects of Prefrontal Pathology in Schizophrenia

1 reference

https://api.crossref.org/works/10.1007%2FS00213-008-1289-2

21 January 2018

Recent advances in the phencyclidine model of schizophrenia

1 reference

https://api.crossref.org/works/10.1007%2FS00213-008-1289-2

21 January 2018

Implications of normal brain development for the pathogenesis of schizophrenia

1 reference

https://api.crossref.org/works/10.1007%2FS00213-008-1289-2

21 January 2018

Reversal and nonreversal shifts under amphetamine.

1 reference

https://api.crossref.org/works/10.1007%2FS00213-008-1289-2

21 January 2018

GDNF and BDNF alter the expression of neuronal NOS, c-Jun, and p75 and prevent motoneuron death following spinal root avulsion in adult rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/18709358

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glutamate and dopamine dysregulation in schizophrenia--a synthesis and selective review

1 reference

https://pubmed.ncbi.nlm.nih.gov/18709358

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurochemical, electrophysiological and pharmacological profiles of the selective inhibitor of the glycine transporter-1 SSR504734, a potential new type of antipsychotic

1 reference

https://pubmed.ncbi.nlm.nih.gov/18709358

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Endothelium-derived relaxing factor release on activation of NMDA receptors suggests role as intercellular messenger in the brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/18709358

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Implications for altered glutamate and GABA metabolism in the dorsolateral prefrontal cortex of aged schizophrenic patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/18709358

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuronal NADPH diaphorase is a nitric oxide synthase

1 reference

https://pubmed.ncbi.nlm.nih.gov/18709358

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Habituation of acoustic startle is disrupted by psychotomimetic drugs: differential dependence on dopaminergic and nitric oxide modulatory mechanisms

1 reference

https://pubmed.ncbi.nlm.nih.gov/18709358

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The "two-headed" latent inhibition model of schizophrenia: modeling positive and negative symptoms and their treatment

1 reference

https://pubmed.ncbi.nlm.nih.gov/18709358

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of glutamatergic neurotransmission by ketamine: a novel step in the pathway from NMDA receptor blockade to dopaminergic and cognitive disruptions associated with the prefrontal cortex

1 reference

https://pubmed.ncbi.nlm.nih.gov/18709358

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The pharmacology of latent inhibition as an animal model of schizophrenia

1 reference

https://pubmed.ncbi.nlm.nih.gov/18709358

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ALX 5407: a potent, selective inhibitor of the hGlyT1 glycine transporter

1 reference

https://pubmed.ncbi.nlm.nih.gov/18709358

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clinical features of latent inhibition in schizophrenia

1 reference

https://pubmed.ncbi.nlm.nih.gov/18709358

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neural substrates of latent inhibition: the switching model

1 reference

https://pubmed.ncbi.nlm.nih.gov/18709358

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

How antipsychotics work-from receptors to reality

1 reference

https://pubmed.ncbi.nlm.nih.gov/18709358

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nitric oxide: a novel link between synaptic and nonsynaptic transmission

1 reference

https://pubmed.ncbi.nlm.nih.gov/18709358

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nitric oxide signaling in the medial prefrontal cortex is involved in the biochemical and behavioral effects of phencyclidine

1 reference

https://pubmed.ncbi.nlm.nih.gov/18709358

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Context, time, and memory retrieval in the interference paradigms of Pavlovian learning

1 reference

https://pubmed.ncbi.nlm.nih.gov/18709358

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phasic versus tonic dopamine release and the modulation of dopamine system responsivity: a hypothesis for the etiology of schizophrenia

1 reference

https://pubmed.ncbi.nlm.nih.gov/18709358

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tonic and phasic nitric oxide signals in hippocampal long-term potentiation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18709358

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prepulse inhibition deficits of the startle reflex in neonatal ventral hippocampal-lesioned rats: reversal by glycine and a glycine transporter inhibitor.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18709358

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

On the effect of neonatal nitric oxide synthase inhibition in rats: a potential neurodevelopmental model of schizophrenia

1 reference

https://pubmed.ncbi.nlm.nih.gov/18709358

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of SSR103800, a selective inhibitor of the glycine transporter-1 in models predictive of therapeutic activity in schizophrenia

1 reference

https://pubmed.ncbi.nlm.nih.gov/18709358

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synaptic signaling by nitric oxide

1 reference

https://pubmed.ncbi.nlm.nih.gov/18709358

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modulation of N-methyl-D-aspartate receptor function by glycine transport

1 reference

https://pubmed.ncbi.nlm.nih.gov/18709358

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neonatal nitric oxide synthase inhibition: social interaction deficits in adulthood and reversal by antipsychotic drugs

1 reference

https://pubmed.ncbi.nlm.nih.gov/18709358

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Schizophrenia: from dopamine to glutamate and back

1 reference

https://pubmed.ncbi.nlm.nih.gov/18709358

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glycine transporter isoforms in the mammalian central nervous system: structures, functions and therapeutic promises

1 reference

https://pubmed.ncbi.nlm.nih.gov/18709358

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cognitive inflexibility and pre-frontal dysfunction in schizophrenia and mania

1 reference

https://pubmed.ncbi.nlm.nih.gov/18709358

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phencyclidine affects memory in a nitric oxide-dependent manner: working and reference memory

1 reference

https://pubmed.ncbi.nlm.nih.gov/18709358

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Abolition of latent inhibition by a single 5 mg dose of d-amphetamine in man.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18709358

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dysfunctional brain dopamine systems induced by psychotomimetic NMDA-receptor antagonists and the effects of antipsychotic drugs

1 reference

https://pubmed.ncbi.nlm.nih.gov/18709358

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A placebo-controlled trial of D-cycloserine added to conventional neuroleptics in patients with schizophrenia

1 reference

https://pubmed.ncbi.nlm.nih.gov/18709358

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cysteine regulation of protein function--as exemplified by NMDA-receptor modulation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18709358

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glycine transporter type 1 blockade changes NMDA receptor-mediated responses and LTP in hippocampal CA1 pyramidal cells by altering extracellular glycine levels

1 reference

https://pubmed.ncbi.nlm.nih.gov/18709358

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phencyclidine animal models of schizophrenia: approaches from abnormality of glutamatergic neurotransmission and neurodevelopment

1 reference

https://pubmed.ncbi.nlm.nih.gov/18709358

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Construct Validity of the Animal Latent Inhibition Model of Selective Attention Deficits in Schizophrenia

1 reference

https://pubmed.ncbi.nlm.nih.gov/18709358

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential involvement of the shell and core subterritories of the nucleus accumbens in latent inhibition and amphetamine-induced activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/18709358

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phencyclidine and genetic animal models of schizophrenia developed in relation to the glutamate hypothesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/18709358

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The delayed effects of DTG and MK-801 on latent inhibition in a conditioned taste-aversion paradigm

1 reference

https://pubmed.ncbi.nlm.nih.gov/18709358

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of the NMDA receptor antagonist ketamine on flavor memory: conditioned aversion, latent inhibition, and habituation of neophobia

1 reference

https://pubmed.ncbi.nlm.nih.gov/18709358

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glutamatergic neurotransmission modulation and the mechanisms of antipsychotic atypicality

1 reference

https://pubmed.ncbi.nlm.nih.gov/18709358

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Can the pharmaceutical industry reduce attrition rates?

1 reference

https://pubmed.ncbi.nlm.nih.gov/18709358

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glutamate pharmacology and the treatment of schizophrenia: current status and future directions

1 reference

https://pubmed.ncbi.nlm.nih.gov/18709358

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interactions between glutamatergic and monoaminergic systems within the basal ganglia-implications for schizophrenia and Parkinson's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/18709358

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pathologically-activated therapeutics for neuroprotection: mechanism of NMDA receptor block by memantine and S-nitrosylation

1 reference

https://pubmed.ncbi.nlm.nih.gov/18709358

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The effects of phencyclidine on latent inhibition in taste aversion conditioning: differential effects of preexposure and conditioning

1 reference

https://pubmed.ncbi.nlm.nih.gov/18709358

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dose-finding trial of D-cycloserine added to neuroleptics for negative symptoms in schizophrenia

1 reference

https://pubmed.ncbi.nlm.nih.gov/18709358

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Localization of the GLYT1 glycine transporter at glutamatergic synapses in the rat brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/18709358

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The delayed effects of phencyclidine (PCP) disrupt latent inhibition in a conditioned taste aversion paradigm.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18709358

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comparative effects of glycine and D-cycloserine on persistent negative symptoms in schizophrenia: a retrospective analysis

1 reference

https://pubmed.ncbi.nlm.nih.gov/18709358

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

D-Cycloserine added to risperidone in patients with primary negative symptoms of schizophrenia

1 reference

https://pubmed.ncbi.nlm.nih.gov/18709358

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Adjunctive high-dose glycine in the treatment of schizophrenia

1 reference

https://pubmed.ncbi.nlm.nih.gov/18709358

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The switching model of latent inhibition: an update of neural substrates

1 reference

https://pubmed.ncbi.nlm.nih.gov/18709358

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The glycine transporter-1 inhibitors NFPS and Org 24461: a pharmacological study

1 reference

https://pubmed.ncbi.nlm.nih.gov/18709358

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Network interactions in schizophrenia - therapeutic implications

1 reference

https://pubmed.ncbi.nlm.nih.gov/18709358

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The neuropsychopharmacology of phencyclidine: from NMDA receptor hypofunction to the dopamine hypothesis of schizophrenia

1 reference

https://pubmed.ncbi.nlm.nih.gov/18709358

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cortical maldevelopment, anti-psychotic drugs, and schizophrenia: a search for common ground

1 reference

https://pubmed.ncbi.nlm.nih.gov/18709358

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glycine reduces novelty- and methamphetamine-induced locomotor activity in neonatal ventral hippocampal damaged rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/18709358

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Stimulation of the metabotropic glutamate 2/3 receptor attenuates social novelty discrimination deficits induced by neonatal phencyclidine treatment

1 reference

https://pubmed.ncbi.nlm.nih.gov/18709358

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phencyclidine does not disrupt latent inhibition in rats: implications for animal models of schizophrenia

1 reference

https://pubmed.ncbi.nlm.nih.gov/18709358

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

D-serine added to antipsychotics for the treatment of schizophrenia

1 reference

https://pubmed.ncbi.nlm.nih.gov/18709358

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The glycine transporter type 1 inhibitor N-[3-(4'-fluorophenyl)-3-(4'-phenylphenoxy)propyl]sarcosine potentiates NMDA receptor-mediated responses in vivo and produces an antipsychotic profile in rodent behavior.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18709358

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of mesolimbic dopaminergic and retrohippocampal afferents to the nucleus accumbens in latent inhibition: implications for schizophrenia

1 reference

https://pubmed.ncbi.nlm.nih.gov/18709358

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

D-cycloserine added to clozapine for patients with schizophrenia

1 reference

https://pubmed.ncbi.nlm.nih.gov/18709358

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Abolition of the expression but not the acquisition of latent inhibition by chronic amphetamine in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/18709358

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nitric oxide synthase inhibition during synaptic maturation decreases synapsin I immunoreactivity in rat brain.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18709358

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of nicotine and amphetamine on latent inhibition in human subjects

1 reference

https://pubmed.ncbi.nlm.nih.gov/18709358

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nitric oxide mediates the formation of synaptic connections in developing and regenerating olfactory receptor neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/18709358

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Impaired inhibition of conditioned responses produced by subchronic administration of phencyclidine to rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/18709358

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glutamatergic animal models of schizophrenia

1 reference

https://pubmed.ncbi.nlm.nih.gov/18709358

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glycine potentiates the NMDA response in cultured mouse brain neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/18709358

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Subanesthetic doses of ketamine stimulate psychosis in schizophrenia

1 reference

https://pubmed.ncbi.nlm.nih.gov/18709358

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

D-serine efficacy as add-on pharmacotherapy to risperidone and olanzapine for treatment-refractory schizophrenia

1 reference

https://pubmed.ncbi.nlm.nih.gov/18709358

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glutamate and schizophrenia: beyond the dopamine hypothesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/18709358

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Systemic administration of MK-801 produces an abnormally persistent latent inhibition which is reversed by clozapine but not haloperidol.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18709358

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Discovery and SAR of org 24598-a selective glycine uptake inhibitor

1 reference

https://pubmed.ncbi.nlm.nih.gov/18709358

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glycine transport inhibitors and the treatment of schizophrenia

1 reference

https://pubmed.ncbi.nlm.nih.gov/18709358

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nitric oxide synthase and neuronal NADPH diaphorase are identical in brain and peripheral tissues

1 reference

https://pubmed.ncbi.nlm.nih.gov/18709358

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The NMDA-receptor antagonist MK-801 selectively disrupts reversal learning in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/18709358

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glutamate as a therapeutic target in psychiatric disorders

1 reference

https://pubmed.ncbi.nlm.nih.gov/18709358

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modulation of striatal dopamine release by glycine transport inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/18709358

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amygdala regulation of nucleus accumbens dopamine output is governed by the prefrontal cortex.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18709358

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Abnormally persistent latent inhibition induced by MK801 is reversed by risperidone and by positive modulators of NMDA receptor function: differential efficacy depending on the stage of the task at which they are administered

1 reference

https://pubmed.ncbi.nlm.nih.gov/18709358

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modulators of the glycine site on NMDA receptors, D-serine and ALX 5407, display similar beneficial effects to clozapine in mouse models of schizophrenia

1 reference

https://pubmed.ncbi.nlm.nih.gov/18709358

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of nucleus accumbens dopamine in motivated behavior: a unifying interpretation with special reference to reward-seeking

1 reference

https://pubmed.ncbi.nlm.nih.gov/18709358

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S00213-008-1289-2

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18709358%20AND%20SRC:MED&resulttype=core&format=json

12 January 2020

Dimensions Publication ID

0 references

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18709358%20AND%20SRC:MED&resulttype=core&format=json

12 January 2020

ResearchGate publication ID

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