(Q43578521)

24 November 2017

title

Cost-benefit tradeoffs in engineered lac operons (English)

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24 November 2017

Tanja Kortemme

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24 November 2017

Matt Eames

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24 November 2017

language of work or name

English

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publication date

1 May 2012

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24 November 2017

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inferred from page(s)

published in

Science

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24 November 2017

volume

336

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24 November 2017

issue

6083

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24 November 2017

page(s)

911-915

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ENZYME INDUCTION AS AN ALL-OR-NONE PHENOMENON

24 November 2017

cites work

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1219083

The cost of expression of Escherichia coli lac operon proteins is in the process, not in the products

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1219083

Optimality and evolutionary tuning of the expression level of a protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1219083

Genetic regulatory mechanisms in the synthesis of proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1219083

Why highly expressed proteins evolve slowly

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCIENCE.1219083

Mistranslation-induced protein misfolding as a dominant constraint on coding-sequence evolution.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1219083

Growth rate-dependent global effects on gene expression in bacteria

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCIENCE.1219083

Interdependence of cell growth and gene expression: origins and consequences.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1219083

Coding-sequence determinants of gene expression in Escherichia coli

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1219083

Interdependence of translation, transcription and mRNA degradation in the lacZ gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1219083

The protein burden of lac operon products

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1219083

The evolutionary consequences of erroneous protein synthesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1219083

Misfolded proteins impose a dosage-dependent fitness cost and trigger a cytosolic unfolded protein response in yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1219083

Regulation of lactose permease activity by the phosphoenolpyruvate:sugar phosphotransferase system: evidence for direct binding of the glucose-specific enzyme III to the lactose permease

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1219083

lac Repressor-operator interaction. VI. The natural inducer of the lac operon.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1219083

One-step inactivation of chromosomal genes in Escherichia coli K-12 using PCR products

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1219083

Fast, easy and efficient: site-specific insertion of transgenes into enterobacterial chromosomes using Tn7 without need for selection of the insertion event

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1219083

Trp-999 of beta-galactosidase (Escherichia coli) is a key residue for binding, catalysis, and synthesis of allolactose, the natural lac operon inducer

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1219083

Structural Basis for the Altered Activity of Gly794 Variants of Escherichia coli β-Galactosidase†

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1219083

Substitutions for Glu-537 of beta-galactosidase from Escherichia coli cause large decreases in catalytic activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1219083

A simple physical model for binding energy hot spots in protein-protein complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1219083

The ClpXP and ClpAP proteases degrade proteins with carboxy-terminal peptide tails added by the SsrA-tagging system

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1219083

Variable coordination of cotranscribed genes in Escherichia coli following antisense repression

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1219083

Exchange, efflux, and substrate binding by cysteine mutants of the lactose permease of Escherichia coli

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1219083

Gratuitous overexpression of genes in Escherichia coli leads to growth inhibition and ribosome destruction

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1219083

Cost of unneeded proteins in E. coli is reduced after several generations in exponential growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1219083

21 January 2018

Identifiers

DOI

10.1126/SCIENCE.1219083

1 reference

24 November 2017

1 reference