(Q43026301)

12 November 2017

title

Synthesis, 3D-QSAR, and structural modeling of benzolactam derivatives with binding affinity for the D(2) and D(3) receptors (English)

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12 November 2017

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12 November 2017

Eduardo Domínguez

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Christian F Masaguer

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Jana Selent

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José Brea

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Manuel Pastor

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Laura López

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12 November 2017

Raquel Ortega

series ordinal

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12 November 2017

Filipe Areias

series ordinal

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12 November 2017

María Isabel Loza

series ordinal

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12 November 2017

language of work or name

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1 August 2010

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12 November 2017

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12 November 2017

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12 November 2017

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12 November 2017

page(s)

1300-1317

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Mesolimbic dopamine D3 receptors and use of antipsychotics in patients with schizophrenia. A postmortem study

12 November 2017

cites work

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000101

Dopamine receptors: molecular biology, biochemistry and behavioural aspects

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000101

7 January 2021

Dopamine receptors: from structure to function

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000101

7 January 2021

Molecular cloning and characterization of a novel dopamine receptor (D3) as a target for neuroleptics

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000101

7 January 2021

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000101

7 January 2021

Selective loss of dopamine D3-type receptor mRNA expression in parietal and motor cortices of patients with chronic schizophrenia

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000101

7 January 2021

Possible implications of the dopamine D(3) receptor in schizophrenia and in antipsychotic drug actions

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000101

7 January 2021

Dopamine D3 receptor antagonists as therapeutic agents

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000101

7 January 2021

Combined alpha2 and D2/3 receptor blockade enhances cortical glutamatergic transmission and reverses cognitive impairment in the rat.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000101

7 January 2021

S33138 (N-[4-[2-[(3aS,9bR)-8-cyano-1,3a,4,9b-tetrahydro[1] benzopyrano[3,4-c]pyrrol-2(3H)-yl)-ethyl]phenyl-acetamide), a preferential dopamine D3 versus D2 receptor antagonist and potential antipsychotic agent: III. Actions in models of therapeutic

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000101

7 January 2021

Subnanomolar dopamine D3 receptor antagonism coupled to moderate D2 affinity results in favourable antipsychotic-like activity in rodent models: I. neurochemical characterisation of RG-15.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000101

7 January 2021

Interactive SAR studies: rational discovery of super-potent and highly selective dopamine D3 receptor antagonists and partial agonists

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000101

7 January 2021

Synthesis, binding affinity and SAR of new benzolactam derivatives as dopamine D3 receptor ligands

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000101

7 January 2021

Development of novel 1,2,3,4-tetrahydroisoquinoline derivatives and closely related compounds as potent and selective dopamine D3 receptor ligands

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000101

7 January 2021

N-(omega-(4-(2-methoxyphenyl)piperazin-1-yl)alkyl)carboxamides as dopamine D2 and D3 receptor ligands

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000101

7 January 2021

Cyclic benzamides as mixed dopamine D2/serotonin 5-HT2 receptor antagonists: potential atypical antipsychotic agents

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000101

7 January 2021

Multi-receptor binding profile of clozapine and olanzapine: a structural study based on the new beta2 adrenergic receptor template

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000101

7 January 2021

Development and validation of AMANDA, a new algorithm for selecting highly relevant regions in Molecular Interaction Fields.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000101

7 January 2021

GRid-INdependent descriptors (GRIND): a novel class of alignment-independent three-dimensional molecular descriptors.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000101

7 January 2021

Dopamine D2, D3, and D4 selective phenylpiperazines as molecular probes to explore the origins of subtype specific receptor binding.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000101

7 January 2021

A single amino acid difference accounts for the pharmacological distinctions between the rat and human 5-hydroxytryptamine1B receptors

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000101

7 January 2021

Residues in the seventh membrane-spanning segment of the dopamine D2 receptor accessible in the binding-site crevice.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000101

7 January 2021

Beta(1)-selective agonist (-)-1-(3,4-dimethoxyphenetylamino)-3-(3,4-dihydroxy)-2-propanol [(-)-RO363] differentially interacts with key amino acids responsible for beta(1)-selective binding in resting and active states

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000101

7 January 2021

Mapping of dopamine D3 receptor binding site by pharmacological characterization of mutants expressed in CHO cells with the Semliki Forest virus system

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000101

7 January 2021

N-(4-(4-(2,3-dichloro- or 2-methoxyphenyl)piperazin-1-yl)butyl)heterobiarylcarboxamides with functionalized linking chains as high affinity and enantioselective D3 receptor antagonists

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000101

7 January 2021

Synthesis and pharmacological screening of some N-(4-substituted-piperazin-1-ylalkyl)-3,4-pyrroledicarboximides

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000101

7 January 2021

Preparation of novel derivatives of pyridothiazine-1,1-dioxide and their CNS and antioxidant properties.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000101

7 January 2021

Synthesis and structure-activity relationships of new arylpiperazines: para substitution with electron-withdrawing groups decrease binding to 5-HT(1A) and D(2A) receptors

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000101

7 January 2021

Structure-activity relationship studies of CNS agents, XV: N-[omega-(4-aryl-1-piperazinyl)alkyl]-2-oxo-1,2,3,4-tetrahydroquinoline s and -4-oxo-1,2,3,4-tetrahydropyrazino[1,2-a]indoles: new, highly potent 5-HT1A ligands

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000101

7 January 2021

Synthesis and SAR of highly potent and selective dopamine D(3)-receptor antagonists: Quinolin(di)one and benzazepin(di)one derivatives. herve.geneste@abbott.com

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000101

7 January 2021

The SWISS-PROT protein knowledgebase and its supplement TrEMBL in 2003

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000101

7 January 2021

CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000101

7 January 2021

The CLUSTAL_X windows interface: flexible strategies for multiple sequence alignment aided by quality analysis tools

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000101

7 January 2021

High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000101

7 January 2021

Crystal structure of the human beta2 adrenergic G-protein-coupled receptor

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000101

7 January 2021

An alpha-carbon template for the transmembrane helices in the rhodopsin family of G-protein-coupled receptors 1 1Edited by R. Huber

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000101

7 January 2021

Comparative protein modelling by satisfaction of spatial restraints

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000101

7 January 2021

A Second Generation Force Field for the Simulation of Proteins, Nucleic Acids, and Organic Molecules

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000101

7 January 2021

PROCHECK: a program to check the stereochemical quality of protein structures

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000101

7 January 2021

Activation of the beta 2-adrenergic receptor involves disruption of an ionic lock between the cytoplasmic ends of transmembrane segments 3 and 6.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000101

7 January 2021

Conformational changes of G protein-coupled receptors during their activation by agonist binding

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000101

7 January 2021

Evidence for a model of agonist-induced activation of 5-hydroxytryptamine 2A serotonin receptors that involves the disruption of a strong ionic interaction between helices 3 and 6.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000101

7 January 2021

Ligand induced conformational states of the 5-HT(1A) receptor

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000101

7 January 2021

Beta2 adrenergic receptor activation. Modulation of the proline kink in transmembrane 6 by a rotamer toggle switch

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000101

7 January 2021

Automatic generation of 3D-atomic coordinates for organic molecules

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000101

7 January 2021

Improved protein-ligand docking using GOLD

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000101

7 January 2021

Site-directed mutagenesis of the human dopamine D2 receptor

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000101

7 January 2021

Generating Optimal Linear PLS Estimations (GOLPE): An Advanced Chemometric Tool for Handling 3D-QSAR Problems

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000101

7 January 2021

Identifiers

DOI

10.1002/CMDC.201000101

1 reference

12 November 2017

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