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English
The telomere deprotection response is functionally distinct from the genomic DNA damage response.
scientific article published on 11 July 2013
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1 reference
stated in
Europe PubMed Central
PMC publication ID
3721072
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23850488%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 March 2020
title
The telomere deprotection response is functionally distinct from the genomic DNA damage response
(English)
1 reference
stated in
Europe PubMed Central
PMC publication ID
3721072
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23850488%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 March 2020
main subject
DNA damage
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author
Anthony J. Cesare
series ordinal
1
1 reference
stated in
Europe PubMed Central
PMC publication ID
3721072
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23850488%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 March 2020
Makoto Hayashi
series ordinal
2
1 reference
stated in
Europe PubMed Central
PMC publication ID
3721072
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23850488%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 March 2020
Jan Karlseder
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4
object named as
Jan Karlseder
1 reference
stated in
Europe PubMed Central
PMC publication ID
3721072
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23850488%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 March 2020
author name string
Laure Crabbe
series ordinal
3
1 reference
stated in
Europe PubMed Central
PMC publication ID
3721072
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23850488%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 March 2020
publication date
11 July 2013
1 reference
stated in
Europe PubMed Central
PMC publication ID
3721072
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23850488%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 March 2020
published in
Molecular Cell
1 reference
stated in
Europe PubMed Central
PMC publication ID
3721072
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23850488%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 March 2020
volume
51
1 reference
stated in
Europe PubMed Central
PMC publication ID
3721072
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23850488%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 March 2020
issue
2
1 reference
stated in
Europe PubMed Central
PMC publication ID
3721072
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23850488%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 March 2020
page(s)
141-155
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stated in
Europe PubMed Central
PMC publication ID
3721072
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23850488%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 March 2020
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A two-step mechanism for TRF2-mediated chromosome-end protection
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A cell cycle-dependent regulatory circuit composed of 53BP1-RIF1 and BRCA1-CtIP controls DNA repair pathway choice
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RIF1 is essential for 53BP1-dependent nonhomologous end joining and suppression of DNA double-strand break resection.
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Human telomeres are tethered to the nuclear envelope during postmitotic nuclear assembly.
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The telomere syndromes
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A three-state model of telomere control over human proliferative boundaries
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25 May 2018
ATM/ATR checkpoint activation downregulates CDC25C to prevent mitotic entry with uncapped telomeres
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25 May 2018
Progressive telomere dysfunction causes cytokinesis failure and leads to the accumulation of polyploid cells
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25 May 2018
A telomere-dependent DNA damage checkpoint induced by prolonged mitotic arrest
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Five dysfunctional telomeres predict onset of senescence in human cells
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25 May 2018
DNA-damage response and repair activities at uncapped telomeres depend on RNF8
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25 May 2018
Chfr and RNF8 synergistically regulate ATM activation
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PubMed Central
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25 May 2018
A Shld1-controlled POT1a provides support for repression of ATR signaling at telomeres through RPA exclusion
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25 May 2018
Reduced histone biosynthesis and chromatin changes arising from a damage signal at telomeres
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25 May 2018
Telomeres avoid end detection by severing the checkpoint signal transduction pathway
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PubMed Central
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25 May 2018
Spontaneous occurrence of telomeric DNA damage response in the absence of chromosome fusions.
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PubMed Central
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25 May 2018
The shelterin protein TRF2 inhibits Chk2 activity at telomeres in the absence of DNA damage.
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PubMed Central
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25 May 2018
53BP1 promotes non-homologous end joining of telomeres by increasing chromatin mobility
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25 May 2018
Protection of telomeres through independent control of ATM and ATR by TRF2 and POT1.
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3721072
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25 May 2018
Chromosome breakage after G2 checkpoint release
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3721072
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25 May 2018
DNA processing is not required for ATM-mediated telomere damage response after TRF2 deletion
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3721072
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25 May 2018
The telomeric protein TRF2 binds the ATM kinase and can inhibit the ATM-dependent DNA damage response
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3721072
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25 May 2018
Senescence Induced by Altered Telomere State, Not Telomere Loss
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PubMed Central
reference URL
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25 May 2018
T-loop assembly in vitro involves binding of TRF2 near the 3' telomeric overhang
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PubMed Central
reference URL
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25 May 2018
Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice
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25 May 2018
ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3721072
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25 May 2018
p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis
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stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3721072
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25 May 2018
Mammalian telomeres end in a large duplex loop
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PubMed Central
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25 May 2018
Essential role of mouse telomerase in highly proliferative organs
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PubMed Central
reference URL
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25 May 2018
Mice Lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3721072
retrieved
25 May 2018
p21 is necessary for the p53-mediated G1 arrest in human cancer cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3721072
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25 May 2018
How Shelterin Solves the Telomere End-Protection Problem
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3721072
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15 August 2018
Ku70 stimulates fusion of dysfunctional telomeres yet protects chromosome ends from homologous recombination
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3721072
retrieved
1 December 2018
Identifiers
DOI
10.1016/J.MOLCEL.2013.06.006
1 reference
stated in
Europe PubMed Central
PMC publication ID
3721072
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23850488%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 March 2020
PMC publication ID
3721072
1 reference
stated in
Europe PubMed Central
PMC publication ID
3721072
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23850488%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 March 2020
PubMed publication ID
23850488
1 reference
stated in
Europe PubMed Central
PMC publication ID
3721072
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23850488%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 March 2020
ResearchGate publication ID
249319296
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