(Q42818181)

English

Discovery of NBI-77860/GSK561679, a potent corticotropin-releasing factor (CRF1) receptor antagonist with improved pharmacokinetic properties

scientific article published on October 25, 2010

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Europe PubMed Central

PubMed publication ID

7 November 2017

Discovery of NBI-77860/GSK561679, a potent corticotropin-releasing factor (CRF1) receptor antagonist with improved pharmacokinetic properties (English)

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Europe PubMed Central

PubMed publication ID

7 November 2017

pharmacokinetics

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based on heuristic

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Marion Lanier

2

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7 November 2017

Manisha Moorjani

3

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7 November 2017

Emily Lin

4

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7 November 2017

Zhiyong Luo

5

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7 November 2017

Xiaohu Zhang

7

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7 November 2017

Yves St Denis

10

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7 November 2017

Romano Di Fabio

11

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Europe PubMed Central

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7 November 2017

Enza Di Modugno

12

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7 November 2017

John Saunders

13

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7 November 2017

John E. Tellew

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21074436

26 August 2024

Deborah H. Slee

6

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21074436

26 August 2024

Sam R. J. Hoare

8

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21074436

26 August 2024

Dimitri E. Grigoriadis

9

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21074436

26 August 2024

John P. Williams

14

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21074436

26 August 2024

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25 October 2010

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7 November 2017

full work available at URL

https://api.elsevier.com/content/article/PII:S0960894X10015568?httpAccept=text/xml

1 reference

10.1016/J.BMCL.2010.10.095

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https://api.elsevier.com/content/article/PII:S0960894X10015568?httpAccept=text/plain

1 reference

10.1016/J.BMCL.2010.10.095

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Bioorganic & Medicinal Chemistry Letters

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7 November 2017

20

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7 November 2017

24

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7259-7264

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The role of corticotropin-releasing factor in depression and anxiety disorders

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The corticotropin-releasing factor receptor: a novel target for the treatment of depression and anxiety-related disorders

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Small molecule antagonists of the corticotropin releasing factor (CRF) receptor: recent medicinal chemistry developments

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Central CRH system in depression and anxiety--evidence from clinical studies with CRH1 receptor antagonists

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High-affinity CRF1 receptor antagonist NBI-34041: preclinical and clinical data suggest safety and efficacy in attenuating elevated stress response

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A 6-week randomized, placebo-controlled trial of CP-316,311 (a selective CRH1 antagonist) in the treatment of major depression

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Multicenter, randomized, double-blind, active comparator and placebo-controlled trial of a corticotropin-releasing factor receptor-1 antagonist in generalized anxiety disorder

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Recent advances in small molecule antagonists of the corticotropin-releasing factor type-1 receptor-focus on pharmacology and pharmacokinetics

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Design of 2,5-dimethyl-3-(6-dimethyl-4-methylpyridin-3-yl)-7-dipropylaminopyrazolo[1,5-a]pyrimidine (NBI 30775/R121919) and structure--activity relationships of a series of potent and orally active corticotropin-releasing factor receptor antagonists

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The discovery of 4-(3-pentylamino)-2,7-dimethyl-8-(2-methyl-4-methoxyphenyl)-pyrazolo-[1 ,5-a]-pyrimidine: a corticotropin-releasing factor (hCRF1) antagonist

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Design and synthesis of tricyclic corticotropin-releasing factor-1 antagonists

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Corticotropin-releasing hormone receptor antagonists: framework design and synthesis guided by ligand conformational studies

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Synthesis of various 3-substituted 1,2,4-oxadiazole-containing chiral beta 3- and alpha-amino acids from Fmoc-protected aspartic acid

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Identifiers

10.1016/J.BMCL.2010.10.095

1 reference

Europe PubMed Central

PubMed publication ID

7 November 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

7 November 2017

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