(Q42810090)

7 November 2017

title

Localization of the PAK1-, WASP-, and IQGAP1-specifying regions of Cdc42. (English)

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7 November 2017

R Li

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7 November 2017

B Debreceni

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7 November 2017

B Jia

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7 November 2017

Y Gao

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7 November 2017

G Tigyi

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7 November 2017

Y Zheng

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7 November 2017

language of work or name

English

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publication date

1 October 1999

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Journal of Biological Chemistry

7 November 2017

published in

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7 November 2017

volume

274

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7 November 2017

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7 November 2017

page(s)

29648-29654

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GTPase cascades choreographing cellular behavior: movement, morphogenesis, and more

7 November 2017

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Role for the Rho-family GTPase Cdc42 in yeast mating-pheromone signal pathway.

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Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia

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Regulation of the polarization of T cells toward antigen-presenting cells by Ras-related GTPase CDC42

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Cdc42 and PAK-mediated signaling leads to Jun kinase and p38 mitogen-activated protein kinase activation

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Rho Family GTPases Regulate p38 Mitogen-activated Protein Kinase through the Downstream Mediator Pak1

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Selective activation of the JNK signaling cascadeand c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs

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The small GTP-binding proteins Rac1 and Cdc42 regulate the activity of the JNK/SAPK signaling pathway

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The 70 kDa S6 kinase complexes with and is activated by the Rho family G proteins Cdc42 and Rac1.

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The Rho family GTPases RhoA, Rac1, and CDC42Hs regulate transcriptional activation by SRF

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An Essential Role for Rho, Rac, and Cdc42 GTPases in Cell Cycle Progression Through G 1

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Rho GTPases and signaling networks

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A brain serine/threonine protein kinase activated by Cdc42 and Rac1

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Emerging from the Pak: the p21-activated protein kinase family.

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A conserved binding motif defines numerous candidate target proteins for both Cdc42 and Rac GTPases

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Human p21-activated kinase (Pak1) regulates actin organization in mammalian cells

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Expression of constitutively active alpha-PAK reveals effects of the kinase on actin and focal complexes

21 January 2018

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Wiskott-Aldrich syndrome protein, a novel effector for the GTPase CDC42Hs, is implicated in actin polymerization

21 January 2018

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Two GTPases, Cdc42 and Rac, bind directly to a protein implicated in the immunodeficiency disorder Wiskott-Aldrich syndrome

21 January 2018

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Direct interaction of the Wiskott-Aldrich syndrome protein with the GTPase Cdc42

21 January 2018

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IQGAP1, a Rac- and Cdc42-binding protein, directly binds and cross-links microfilaments

21 January 2018

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Role of IQGAP1, a target of the small GTPases Cdc42 and Rac1, in regulation of E-cadherin- mediated cell-cell adhesion

21 January 2018

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Structural requirements for PAK activation by Rac GTPases

21 January 2018

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Different regions of Rho determine Rho-selective binding of different classes of Rho target molecules.

21 January 2018

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Determination of interaction sites on the small G protein RhoA for phospholipase D

21 January 2018

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Residues of the Rho family GTPases Rho and Cdc42 that specify sensitivity to Dbl-like guanine nucleotide exchange factors.

21 January 2018

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Structural Determinants Required for the Interaction between Rho GTPase and the GTPase-activating Domain of p190

21 January 2018

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Characterization of the interactions between the small GTPase Cdc42 and its GTPase-activating proteins and putative effectors. Comparison of kinetic properties of Cdc42 binding to the Cdc42-interactive domains

21 January 2018

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Interaction of Rac1 with GTPase-activating proteins and putative effectors. A comparison with Cdc42 and RhoA

21 January 2018

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The faciogenital dysplasia gene product FGD1 functions as a Cdc42Hs-specific guanine-nucleotide exchange factor

21 January 2018

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Definition of the switch surface in the solution structure of Cdc42Hs

21 January 2018

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21 January 2018

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RhoA effector mutants reveal distinct effector pathways for cytoskeletal reorganization, SRF activation and transformation.

21 January 2018

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Rac and Cdc42 induce actin polymerization and G1 cell cycle progression independently of p65PAK and the JNK/SAPK MAP kinase cascade

21 January 2018

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Rac regulation of transformation, gene expression, and actin organization by multiple, PAK-independent pathways

21 January 2018

1 reference

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The 2.2 A crystal structure of the Ras-binding domain of the serine/threonine kinase c-Raf1 in complex with Rap1A and a GTP analogue

21 January 2018

1 reference

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Identification of small clusters of divergent amino acids that mediate the opposing effects of ras and Krev-1.

21 January 2018

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Negative regulation of Rho family GTPases Cdc42 and Rac2 by homodimer formation

21 January 2018

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An activated Rac mutant functions as a dominant negative for membrane ruffling

21 January 2018

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Transformation activity of Cdc42 requires a region unique to Rho-related proteins

21 January 2018

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Use of a fluorescence spectroscopic readout to characterize the interactions of Cdc42Hs with its target/effector, mPAK-3.

21 January 2018

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Loop 6 of RhoA confers specificity for effector binding, stress fiber formation, and cellular transformation

21 January 2018

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Induction of filopodium formation by a WASP-related actin-depolymerizing protein N-WASP

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.42.29648

A Cdc42 target protein with homology to the non-kinase domain of FER has a potential role in regulating the actin cytoskeleton

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.42.29648

The Cdc42/Rac interactive binding region motif of the Wiskott Aldrich syndrome protein (WASP) is necessary but not sufficient for tight binding to Cdc42 and structure formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.42.29648

PAK4, a novel effector for Cdc42Hs, is implicated in the reorganization of the actin cytoskeleton and in the formation of filopodia

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.42.29648

The interaction between N-WASP and the Arp2/3 complex links Cdc42-dependent signals to actin assembly

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.42.29648

Structure of Cdc42 in complex with the GTPase-binding domain of the 'Wiskott-Aldrich syndrome' protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.42.29648

Muscarinic receptors transform NIH 3T3 cells through a Ras-dependent signalling pathway inhibited by the Ras-GTPase-activating protein SH3 domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.42.29648

Structural basis for the interaction of Ras with RalGDS

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.42.29648

21 January 2018

Identifiers

DOI

10.1074/JBC.274.42.29648

1 reference

7 November 2017

1 reference