(Q42805965)

English

Phorbol ester-induced downregulation of CD4 is a multistep process involving dissociation from p56lck, increased association with clathrin-coated pits, and altered endosomal sorting

scientific article published on October 1993

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

7 November 2017

Phorbol ester-induced downregulation of CD4 is a multistep process involving dissociation from p56lck, increased association with clathrin-coated pits, and altered endosomal sorting (English)

1 reference

Europe PubMed Central

PMC publication ID

7 November 2017

3

1 reference

Europe PubMed Central

PMC publication ID

7 November 2017

author name string

Pelchen-Matthews A

1

1 reference

Europe PubMed Central

PMC publication ID

7 November 2017

Parsons IJ

2

1 reference

Europe PubMed Central

PMC publication ID

7 November 2017

language of work or name

0 references

publication date

1 October 1993

1 reference

Europe PubMed Central

PMC publication ID

7 November 2017

Journal of Experimental Medicine

1 reference

Europe PubMed Central

PMC publication ID

7 November 2017

178

1 reference

Europe PubMed Central

PMC publication ID

7 November 2017

4

1 reference

Europe PubMed Central

PMC publication ID

7 November 2017

1209-1222

1 reference

Europe PubMed Central

PMC publication ID

7 November 2017

Mechanism of action of the monosialoganglioside GM1 as a modulator of CD4 expression. Evidence that GM1-CD4 interaction triggers dissociation of p56lck from CD4, and CD4 internalization and degradation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2191214

27 May 2018

Phorbol myristate acetate stimulates pinocytosis and membrane spreading in mouse peritoneal macrophages

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2191214

27 May 2018

Inhibition of receptor-mediated but not fluid-phase endocytosis in polymorphonuclear leukocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2191214

27 May 2018

Phorbol esters and horseradish peroxidase stimulate pinocytosis and redirect the flow of pinocytosed fluid in macrophages

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2191214

27 May 2018

Down-regulation of protein kinase C is due to an increased rate of degradation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2191214

27 May 2018

Two threshold values of low pH block endocytosis at different stages.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2191214

27 May 2018

HIV infection does not require endocytosis of its receptor, CD4.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2191214

27 May 2018

Internalization of the human immunodeficiency virus does not require the cytoplasmic domain of CD4.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2191214

27 May 2018

Human immunodeficiency virus infection of monocytic and T-lymphocytic cells: receptor modulation and differentiation induced by phorbol ester

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2191214

27 May 2018

The distribution of 215-kilodalton mannose 6-phosphate receptors within cis (heavy) and trans (light) Golgi subfractions varies in different cell types

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2191214

27 May 2018

Phosphorylation of CD4 and CD8 molecules following T cell triggering

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2191214

27 May 2018

Gangliosides induce selective modulation of CD4 from helper T lymphocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2191214

27 May 2018

Acidification of the cytosol inhibits endocytosis from coated pits

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2191214

27 May 2018

The CD4 antigen: physiological ligand and HIV receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2191214

27 May 2018

Regulation of CD4 and CD8 surface expression on human thymocyte subpopulations by triggering through CD2 and the CD3-T cell receptor.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2191214

27 May 2018

A quantitative analysis of the endocytic pathway in baby hamster kidney cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2191214

27 May 2018

Internalization and recycling of CD4 transfected into HeLa and NIH3T3 cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2191214

27 May 2018

Hypertonic media inhibit receptor-mediated endocytosis by blocking clathrin-coated pit formation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2191214

27 May 2018

Class II MHC molecules and the HIV gp 120 envelope protein interact with functionally distinct regions of the CD4 molecule

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2191214

27 May 2018

Molecular biology and function of CD4 and CD8

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2191214

27 May 2018

Endocytosis and recycling of CD4.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2191214

27 May 2018

Lymphocyte mitogenesis and CD4 modulation induced by different phorbol esters: comparative studies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2191214

27 May 2018

Phosphorylation of the polymeric immunoglobulin receptor required for its efficient transcytosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2191214

27 May 2018

Short related sequences in the cytoplasmic domains of CD4 and CD8 mediate binding to the amino-terminal domain of the p56lck tyrosine protein kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2191214

27 May 2018

Interaction of the unique N-terminal region of tyrosine kinase p56lck with cytoplasmic domains of CD4 and CD8 is mediated by cysteine motifs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2191214

27 May 2018

CD4: collaborator in immune recognition and HIV infection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2191214

27 May 2018

Structural features of the cytoplasmic region of CD4 required for internalization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2191214

27 May 2018

Effect of human immunodeficiency virus gp120 glycoprotein on the association of the protein tyrosine kinase p56lck with CD4 in human T lymphocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2191214

27 May 2018

CD4 and CD8 act as co-receptors during thymic selection of the T cell repertoire

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2191214

27 May 2018

The lymphocyte-specific tyrosine protein kinase p56lck

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2191214

27 May 2018

The roles of CD4 and CD8 in T cell activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2191214

27 May 2018

Differential endocytosis of CD4 in lymphocytic and nonlymphocytic cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2191214

27 May 2018

The cytoplasmic tail of CD4 targets chimeric molecules to a degradative pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2191214

27 May 2018

Fc receptor endocytosis is controlled by a cytoplasmic domain determinant that actively prevents coated pit localization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2191214

27 May 2018

Novel anti-CD4 monoclonal antibodies separate human immunodeficiency virus infection and fusion of CD4+ cells from virus binding

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2191214

27 May 2018

Phosphorylation-dependent down-modulation of CD4 requires a specific structure within the cytoplasmic domain of CD4.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2191214

27 May 2018

Consensus sequences as substrate specificity determinants for protein kinases and protein phosphatases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2191214

27 May 2018

Internalization, lysosomal degradation and new synthesis of surface membrane CD4 in phorbol ester-activated T-lymphocytes and U-937 cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2191214

27 May 2018

A novel di-leucine motif and a tyrosine-based motif independently mediate lysosomal targeting and endocytosis of CD3 chains

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2191214

27 May 2018

Internalization of HIV glycoprotein gp120 is associated with down-modulation of membrane CD4 and p56lck together with impairment of T cell activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2191214

27 May 2018

Degradation of CD4 following phorbol-induced internalization in human T lymphocytes. Evidence for distinct endocytic routing of CD4 and CD3

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2191214

27 May 2018

Disruption of the CD4-p56lck complex is required for rapid internalization of CD4

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2191214

27 May 2018

The cytoplasmic tail of the mannose 6-phosphate/insulin-like growth factor-II receptor has two signals for lysosomal enzyme sorting in the Golgi

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2191214

27 May 2018

The protein tyrosine kinase p56lck inhibits CD4 endocytosis by preventing entry of CD4 into coated pits

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2191214

27 May 2018

Morphological analysis of the regulation of CD4 endocytosis by p56lck

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2191214

27 May 2018

A lymphocyte-specific protein tyrosine kinase, p56lck, regulates the PMA-induced internalization of CD4

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2191214

27 May 2018

Role of the coated endocytic vesicle in the uptake of receptor-bound low density lipoprotein in human fibroblasts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2191214

27 May 2018

T4 endocytosis and phosphorylation induced by phorbol esters but not by mitogen or HIV infection.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2191214

27 May 2018

Transient modulation and internalization of T4 antigen induced by phorbol esters.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2191214

27 May 2018

Adsorptive endocytosis of Semliki Forest virus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2191214

16 August 2018

Alterations in T4 (CD4) protein and mRNA synthesis in cells infected with HIV

1 reference

https://pubmed.ncbi.nlm.nih.gov/8376930

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The structure of an endocytosis signal

1 reference

https://pubmed.ncbi.nlm.nih.gov/8376930

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activators of protein kinase C induce dissociation of CD4, but not CD8, from p56lck

1 reference

https://pubmed.ncbi.nlm.nih.gov/8376930

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Surface membrane CD4 turnover in phorbol ester stimulated T-lymphocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/8376930

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The mannose 6-phosphate receptor and the biogenesis of lysosomes

1 reference

https://pubmed.ncbi.nlm.nih.gov/8376930

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rapid phosphorylation and modulation of the T4 antigen on cloned helper T cells induced by phorbol myristate acetate or antigen

1 reference

https://pubmed.ncbi.nlm.nih.gov/8376930

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CD4 molecules are associated with the antigen receptor complex on activated but not resting T cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/8376930

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modulation of CD4 by antigenic activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/8376930

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phorbol esters down-regulate transcription and translation of the CD4 gene

1 reference

https://pubmed.ncbi.nlm.nih.gov/8376930

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutational analysis of the interaction between CD4 and class II MHC: class II antigens contact CD4 on a surface opposite the gp120-binding site

1 reference

https://pubmed.ncbi.nlm.nih.gov/8376930

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cell surface comodulation of CD4 and T cell receptor by anti-CD4 monoclonal antibody

1 reference

https://pubmed.ncbi.nlm.nih.gov/8376930

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1084/JEM.178.4.1209

1 reference

Europe PubMed Central

PMC publication ID

7 November 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

7 November 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

7 November 2017

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