(Q42709265)

5 November 2017

title

Filaggrin deficiency leads to impaired lipid profile and altered acidification pathways in a 3D skin construct (English)

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5 November 2017

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14 June 2020

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14 June 2020

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14 June 2020

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14 June 2020

Dominika Henkes

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14 June 2020

Kay Strüver

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14 June 2020

Madeleine Y Witting

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14 June 2020

Wolfgang Friess

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14 June 2020

Robert J Meier

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14 June 2020

Joachim W Fluhr

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14 June 2020

Sarah Küchler

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14 June 2020

Monika Schäfer-Korting

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14 June 2020

language of work or name

English

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publication date

23 September 2013

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Journal of Investigative Dermatology

5 November 2017

published in

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14 June 2020

volume

134

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14 June 2020

issue

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14 June 2020

page(s)

746-753

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Abnormalities in Epidermal Lipid Metabolism in Patients with Atopic Dermatitis

14 June 2020

cites work

1 reference

12 December 2020

Moisturization and skin barrier function

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12 December 2020

Atopic dermatitis: therapeutic concepts evolving from new pathophysiologic insights

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12 December 2020

Lipids and barrier function of the skin

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12 December 2020

Unraveling barrier properties of three different in-house human skin equivalents

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12 December 2020

Generation of free fatty acids from phospholipids regulates stratum corneum acidification and integrity

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12 December 2020

Full-thickness human skin models for congenital ichthyosis and related keratinization disorders

1 reference

12 December 2020

Is the filaggrin-histidine-urocanic acid pathway essential for stratum corneum acidification?

1 reference

12 December 2020

Evidence for the existence of a self-regulated enzymatic process within the human stratum corneum -an unexpected role for urocanic acid

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12 December 2020

Filaggrin in atopic dermatitis

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12 December 2020

Ceramide profiles of the uninvolved skin in atopic dermatitis and psoriasis are comparable to those of healthy skin

1 reference

12 December 2020

Changes in the ceramide profile of atopic dermatitis patients

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12 December 2020

Thematic review series: skin lipids. The role of epidermal lipids in cutaneous permeability barrier homeostasis

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12 December 2020

A possible mechanism underlying the ceramide deficiency in atopic dermatitis: expression of a deacylase enzyme that cleaves the N-acyl linkage of sphingomyelin and glucosylceramide

1 reference

12 December 2020

Synthesis of fluorescent C24-ceramide: evidence for acyl chain length dependent differences in penetration of exogenous NBD-ceramides into human skin

1 reference

12 December 2020

Two ceramide subfractions detectable in Cer(AS) position by HPTLC in skin surface lipids of non-lesional skin of atopic eczema

1 reference

12 December 2020

Hallmarks of atopic skin mimicked in vitro by means of a skin disease model based on FLG knock-down.

1 reference

12 December 2020

PREPARATION OF ISOLATED SHEETS OF HUMAN STRATUM CORNEUM

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12 December 2020

The use of reconstructed human epidermis for skin absorption testing: Results of the validation study

1 reference

12 December 2020

Lamellar Lipid Organization and Ceramide Composition in the Stratum Corneum of Patients with Atopic Eczema

1 reference

12 December 2020

Comparison of rat epidermal keratinocyte organotypic culture (ROC) with intact human skin: lipid composition and thermal phase behavior of the stratum corneum

1 reference

12 December 2020

High-expression of sphingomyelin deacylase is an important determinant of ceramide deficiency leading to barrier disruption in atopic dermatitis

1 reference

12 December 2020

NHE1 regulates the stratum corneum permeability barrier homeostasis. Microenvironment acidification assessed with fluorescence lifetime imaging

1 reference

12 December 2020

Short-chain ceramides decrease skin barrier properties.

1 reference

12 December 2020

Lipid biophysics of water loss through the skin

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12 December 2020

Decrease of Ceramides with Very Long–Chain Fatty Acids and Downregulation of Elongases in a Murine Atopic Dermatitis Model

1 reference

12 December 2020

Variability of enzyme markers during clinical regression of atopic dermatitis

1 reference

12 December 2020

Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis

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12 December 2020

Skin Barrier Function in Healthy Subjects and Patients with Atopic Dermatitis in Relation to Filaggrin Loss-of-Function Mutations

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12 December 2020

Aberrant lipid organization in stratum corneum of patients with atopic dermatitis and lamellar ichthyosis

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12 December 2020

A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION

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12 December 2020

Ceramide and cholesterol composition of the skin of patients with atopic dermatitis

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12 December 2020

Simultaneous photographing of oxygen and pH in vivo using sensor films

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12 December 2020

Influence of the lipid composition on the organization of skin lipid model mixtures: an infrared spectroscopy investigation

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12 December 2020

Knockdown of filaggrin impairs diffusion barrier function and increases UV sensitivity in a human skin model

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12 December 2020

Noninvasive characterization of human stratum corneum of undiseased skin of patients with atopic dermatitis and psoriasis as studied by Fourier transform Raman spectroscopy

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12 December 2020

Acidification in the epidermis and the role of secretory phospholipases

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12 December 2020

Infrared determination of conformational order and phase behavior in ceramides and stratum corneum models

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12 December 2020

2D luminescence imaging of pH in vivo

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12 December 2020

Skin constructs for replacement of skin tissues for in vitro testing

1 reference

12 December 2020

Stratum corneum acidification in neonatal skin: secretory phospholipase A2 and the sodium/hydrogen antiporter-1 acidify neonatal rat stratum corneum.

1 reference

12 December 2020

Abnormal expression of the novel epidermal enzyme, glucosylceramide deacylase, and the accumulation of its enzymatic reaction product, glucosylsphingosine, in the skin of patients with atopic dermatitis.

1 reference

12 December 2020

Decreased level of ceramides in stratum corneum of atopic dermatitis: an etiologic factor in atopic dry skin?

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12 December 2020

One remarkable molecule: filaggrin.

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12 December 2020

Identifiers

DOI

10.1038/JID.2013.402

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24061166%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

14 June 2020

1035166555

0 references

1 reference

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