(Q42639115)

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A phase I open-label, dose-escalation, multi-institutional trial of injection with an E1B-Attenuated adenovirus, ONYX-015, into the peritumoral region of recurrent malignant gliomas, in the adjuvant setting.

scientific article published on November 2004

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15509513%20AND%20SRC:MED&resulttype=core&format=json

4 January 2020

A phase I open-label, dose-escalation, multi-institutional trial of injection with an E1B-Attenuated adenovirus, ONYX-015, into the peritumoral region of recurrent malignant gliomas, in the adjuvant setting (English)

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4 January 2020

phase I clinical trial

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4 January 2020

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Tom Mikkelsen

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4 January 2020

Kathryn A Carson

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Kathryn Carson

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4 January 2020

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E Antonio Chiocca

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4 January 2020

Khalid M Abbed

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4 January 2020

Stephen Tatter

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4 January 2020

David N Louis

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4 January 2020

Fred H Hochberg

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Fred Barker

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Jean Kracher

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4 January 2020

Stuart A Grossman

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4 January 2020

Joy D Fisher

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4 January 2020

Mark Rosenblum

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4 January 2020

Jeff Olson

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4 January 2020

James Markert

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4 January 2020

Steven Rosenfeld

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4 January 2020

Steven Brem

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4 January 2020

Surasak Phuphanich

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4 January 2020

Scott Freeman

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4 January 2020

Rick Kaplan

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4 January 2020

James Zwiebel

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4 January 2020

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1 November 2004

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4 January 2020

Molecular Therapy

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4 January 2020

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4 January 2020

5

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4 January 2020

958-966

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4 January 2020

The WHO classification of tumors of the nervous system

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Replication-selective virotherapy for cancer: Biological principles, risk management and future directions

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An adenovirus mutant that replicates selectively in p53-deficient human tumor cells

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Evidence that replication of the antitumor adenovirus ONYX-015 is not controlled by the p53 and p14(ARF) tumor suppressor genes.

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7 January 2021

Pilot trial of intravenous infusion of a replication-selective adenovirus (ONYX-015) in combination with chemotherapy or IL-2 treatment in refractory cancer patients

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7 January 2021

Safety and feasibility of injection with an E1B-55 kDa gene-deleted, replication-selective adenovirus (ONYX-015) into primary carcinomas of the pancreas: a phase I trial

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7 January 2021

Phase II trial of intratumoral administration of ONYX-015, a replication-selective adenovirus, in patients with refractory head and neck cancer

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7 January 2021

A prospective phase II trial of ONYX-015 adenovirus and chemotherapy in recurrent squamous cell carcinoma of the head and neck (the Baylor experience).

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7 January 2021

a controlled trial of intratumoral ONYX-015, a selectively-replicating adenovirus, in combination with cisplatin and 5-fluorouracil in patients with recurrent head and neck cancer

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7 January 2021

Conditionally replicating herpes simplex virus mutant, G207 for the treatment of malignant glioma: results of a phase I trial

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The potential for efficacy of the modified (ICP 34.5(-)) herpes simplex virus HSV1716 following intratumoural injection into human malignant glioma: a proof of principle study

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Phase I study of adenoviral delivery of the HSV-tk gene and ganciclovir administration in patients with current malignant brain tumors.

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7 January 2021

Treatment of relapsed malignant glioma with an adenoviral vector containing the herpes simplex thymidine kinase gene followed by ganciclovir

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Adenovirus/herpes simplex-thymidine kinase/ganciclovir complex: preliminary results of a phase I trial in patients with recurrent malignant gliomas.

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Chronic brain inflammation and persistent herpes simplex virus 1 thymidine kinase expression in survivors of syngeneic glioma treated by adenovirus-mediated gene therapy: implications for clinical trials

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Gene transfer into experimental brain tumors mediated by adenovirus, herpes simplex virus, and retrovirus vectors

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Adenovirus gene transfer causes inflammation in the brain

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Adenovirus infection induces microglial activation: involvement of mitogen-activated protein kinase pathways

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7 January 2021

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